The PKM2 activator TEPP‐46 suppresses kidney fibrosis via inhibition of the EMT program and aberrant glycolysis associated with suppression of HIF‐1α accumulation

The PKM2 activator TEPP‐46 suppresses kidney fibrosis via inhibition of the EMT program and aberrant glycolysis associated with suppression of HIF‐1α accumulation

Abstract Aims/Introduction Tubulointerstitial fibrosis is a hallmark of diabetic nephropathy and is associated with an epithelial‐to‐mesenchymal transition (EMT) program and aberrant glycolysis. Dimeric pyruvate kinase (PK) M2 (PKM2) acts as a key protein kinase in aberrant glycolysis by promoting t...

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Bibliographic Details
Main Authors: Haijie Liu, Yuta Takagaki, Asako Kumagai, Keizo Kanasaki, Daisuke Koya
Format: Article
Language:English
Published: Wiley 2021-05-01
Series:Journal of Diabetes Investigation
Subjects:
Diabetic nephropathy
EMT
Glycolysis
Online Access:https://doi.org/10.1111/jdi.13478

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