Dry-coated live viral vector vaccines delivered by nanopatch microprojections retain long-term thermostability and induce transgene-specific T cell responses in mice.

Dry-coated live viral vector vaccines delivered by nanopatch microprojections retain long-term thermostability and induce transgene-specific T cell responses in mice.

The disadvantages of needle-based immunisation motivate the development of simple, low cost, needle-free alternatives. Vaccine delivery to cutaneous environments rich in specialised antigen-presenting cells using microprojection patches has practical and immunological advantages over conventional ne...

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Bibliographic Details
Main Authors: Frances E Pearson, Celia L McNeilly, Michael L Crichton, Clare A Primiero, Sally R Yukiko, Germain J P Fernando, Xianfeng Chen, Sarah C Gilbert, Adrian V S Hill, Mark A F Kendall
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23874462/?tool=EBI

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