The Flavoring Agent Dihydrocoumarin Reverses Epigenetic Silencing and Inhibits Sirtuin Deacetylases.

The Flavoring Agent Dihydrocoumarin Reverses Epigenetic Silencing and Inhibits Sirtuin Deacetylases.

Sirtuins are a family of phylogenetically conserved nicotinamide adenine dinucleotide-dependent deacetylases that have a firmly established role in aging. Using a simple Saccharomyces cerevisiae yeast heterochromatic derepression assay, we tested a number of environmental chemicals to address the po...

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Bibliographic Details
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2005-12-01
Series:	PLoS Genetics
Online Access:	http://dx.doi.org/10.1371/journal.pgen.0010077

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