RNase κ promotes robust piRNA production by generating 2′,3′-cyclic phosphate-containing precursors
Mature piRNAs are produced from long single-stranded precursor RNAs. Here the authors show that RNase κ generates 2′,3′-cyclic phosphate-containing piRNA precursors and promotes piRNA production.
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-24681-w |
| _version_ | 1818997186021556224 |
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| author | Megumi Shigematsu Takuya Kawamura Keisuke Morichika Natsuko Izumi Takashi Kiuchi Shozo Honda Venetia Pliatsika Ryuma Matsubara Isidore Rigoutsos Susumu Katsuma Yukihide Tomari Yohei Kirino |
| author_facet | Megumi Shigematsu Takuya Kawamura Keisuke Morichika Natsuko Izumi Takashi Kiuchi Shozo Honda Venetia Pliatsika Ryuma Matsubara Isidore Rigoutsos Susumu Katsuma Yukihide Tomari Yohei Kirino |
| author_sort | Megumi Shigematsu |
| collection | DOAJ |
| description | Mature piRNAs are produced from long single-stranded precursor RNAs. Here the authors show that RNase κ generates 2′,3′-cyclic phosphate-containing piRNA precursors and promotes piRNA production. |
| first_indexed | 2024-12-20T21:41:37Z |
| format | Article |
| id | doaj.art-939dadb0138143918c8127b14eb6589f |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:41:37Z |
| publishDate | 2021-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-939dadb0138143918c8127b14eb6589f2022-12-21T19:25:48ZengNature PortfolioNature Communications2041-17232021-07-0112111310.1038/s41467-021-24681-wRNase κ promotes robust piRNA production by generating 2′,3′-cyclic phosphate-containing precursorsMegumi Shigematsu0Takuya Kawamura1Keisuke Morichika2Natsuko Izumi3Takashi Kiuchi4Shozo Honda5Venetia Pliatsika6Ryuma Matsubara7Isidore Rigoutsos8Susumu Katsuma9Yukihide Tomari10Yohei Kirino11Computational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson UniversityComputational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson UniversityComputational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson UniversityInstitute for Quantitative Biosciences, The University of TokyoDepartment of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of TokyoComputational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson UniversityComputational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson UniversityComputational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson UniversityComputational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson UniversityDepartment of Agricultural and Environmental Biology, Graduate School of Agricultural and Life Sciences, The University of TokyoInstitute for Quantitative Biosciences, The University of TokyoComputational Medicine Center, Sidney Kimmel Medical College, Thomas Jefferson UniversityMature piRNAs are produced from long single-stranded precursor RNAs. Here the authors show that RNase κ generates 2′,3′-cyclic phosphate-containing piRNA precursors and promotes piRNA production.https://doi.org/10.1038/s41467-021-24681-w |
| spellingShingle | Megumi Shigematsu Takuya Kawamura Keisuke Morichika Natsuko Izumi Takashi Kiuchi Shozo Honda Venetia Pliatsika Ryuma Matsubara Isidore Rigoutsos Susumu Katsuma Yukihide Tomari Yohei Kirino RNase κ promotes robust piRNA production by generating 2′,3′-cyclic phosphate-containing precursors Nature Communications |
| title | RNase κ promotes robust piRNA production by generating 2′,3′-cyclic phosphate-containing precursors |
| title_full | RNase κ promotes robust piRNA production by generating 2′,3′-cyclic phosphate-containing precursors |
| title_fullStr | RNase κ promotes robust piRNA production by generating 2′,3′-cyclic phosphate-containing precursors |
| title_full_unstemmed | RNase κ promotes robust piRNA production by generating 2′,3′-cyclic phosphate-containing precursors |
| title_short | RNase κ promotes robust piRNA production by generating 2′,3′-cyclic phosphate-containing precursors |
| title_sort | rnase κ promotes robust pirna production by generating 2 3 cyclic phosphate containing precursors |
| url | https://doi.org/10.1038/s41467-021-24681-w |
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