Protective effects of Astragalus kahiricus root extract on ethanol-induced retrograde memory impairments in mice
Introduction: Alzheimer’s disease (AD) is a neurodegenerative disorder that has no definite cure. Currently, there is great interest in using plant-based medicines to treat AD. In the present study, the neuroprotective effects of Astragalus kahiricus root extract were evaluated in a retrograde amnes...
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| Format: | Article |
| Language: | English |
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Shahrekord University of Medical Sciences
2019-10-01
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| Series: | Journal of HerbMed Pharmacology |
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| Online Access: | http://herbmedpharmacol.com/PDF/jhp-16387 |
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| author | Basma M. Abdelaziz Maged W. Helmy Mohamed A. Katary Mohammad M. Abd-Alhaseeb Asser I. Ghoneim |
| author_facet | Basma M. Abdelaziz Maged W. Helmy Mohamed A. Katary Mohammad M. Abd-Alhaseeb Asser I. Ghoneim |
| author_sort | Basma M. Abdelaziz |
| collection | DOAJ |
| description | Introduction: Alzheimer’s disease (AD) is a neurodegenerative disorder that has no definite cure. Currently, there is great interest in using plant-based medicines to treat AD. In the present study, the neuroprotective effects of Astragalus kahiricus root extract were evaluated in a retrograde amnesia model.Methods: Male albino mice were given four training sessions in the Morris water maze for seven consecutive days. Treated groups were administered A. kahiricus (25 or 50 mg/kg, i.p.) before ethanol (3.5 gm/kg, i.p) injection. All animals were given a test session in the Morris water maze apparatus. Acetylcholinesterase activity and the levels of oxidative stress biomarkers were also measured.Results: Memory impairment was observed, after ethanol administration, as increased escape latency time and path length travelled by the animals. On the other hand, A. kahiricus significantly reduced both escape latency time and path length. In addition, the extract demonstrated an inhibitory effect on acetylcholinesterase activity and total nitrite level. Moreover, A. kahiricus significantly increased the level of reduced glutathione in mice brain.Conclusion: This study demonstrated the potential behavioural and biochemical neuroprotective properties of A. kahiricus root extract, which might further be considered an important candidate for the treatment of AD. |
| first_indexed | 2024-04-11T15:55:52Z |
| format | Article |
| id | doaj.art-939f553776704b1bb4dd1935325154bf |
| institution | Directory Open Access Journal |
| issn | 2345-5004 |
| language | English |
| last_indexed | 2024-04-11T15:55:52Z |
| publishDate | 2019-10-01 |
| publisher | Shahrekord University of Medical Sciences |
| record_format | Article |
| series | Journal of HerbMed Pharmacology |
| spelling | doaj.art-939f553776704b1bb4dd1935325154bf2022-12-22T04:15:09ZengShahrekord University of Medical SciencesJournal of HerbMed Pharmacology2345-50042019-10-018429530110.15171/jhp.2019.43jhp-16387Protective effects of Astragalus kahiricus root extract on ethanol-induced retrograde memory impairments in miceBasma M. Abdelaziz0Maged W. Helmy1Mohamed A. Katary2Mohammad M. Abd-Alhaseeb3Asser I. Ghoneim4Department of Pharmacology and Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour, EgyptDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour, EgyptDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour, EgyptDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour, EgyptDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Damanhour University, Damanhour, EgyptIntroduction: Alzheimer’s disease (AD) is a neurodegenerative disorder that has no definite cure. Currently, there is great interest in using plant-based medicines to treat AD. In the present study, the neuroprotective effects of Astragalus kahiricus root extract were evaluated in a retrograde amnesia model.Methods: Male albino mice were given four training sessions in the Morris water maze for seven consecutive days. Treated groups were administered A. kahiricus (25 or 50 mg/kg, i.p.) before ethanol (3.5 gm/kg, i.p) injection. All animals were given a test session in the Morris water maze apparatus. Acetylcholinesterase activity and the levels of oxidative stress biomarkers were also measured.Results: Memory impairment was observed, after ethanol administration, as increased escape latency time and path length travelled by the animals. On the other hand, A. kahiricus significantly reduced both escape latency time and path length. In addition, the extract demonstrated an inhibitory effect on acetylcholinesterase activity and total nitrite level. Moreover, A. kahiricus significantly increased the level of reduced glutathione in mice brain.Conclusion: This study demonstrated the potential behavioural and biochemical neuroprotective properties of A. kahiricus root extract, which might further be considered an important candidate for the treatment of AD.http://herbmedpharmacol.com/PDF/jhp-16387Alzheimer’s diseaseAstragalus kahiricusMorris water mazeRetrograde memory impairment |
| spellingShingle | Basma M. Abdelaziz Maged W. Helmy Mohamed A. Katary Mohammad M. Abd-Alhaseeb Asser I. Ghoneim Protective effects of Astragalus kahiricus root extract on ethanol-induced retrograde memory impairments in mice Journal of HerbMed Pharmacology Alzheimer’s disease Astragalus kahiricus Morris water maze Retrograde memory impairment |
| title | Protective effects of Astragalus kahiricus root extract on ethanol-induced retrograde memory impairments in mice |
| title_full | Protective effects of Astragalus kahiricus root extract on ethanol-induced retrograde memory impairments in mice |
| title_fullStr | Protective effects of Astragalus kahiricus root extract on ethanol-induced retrograde memory impairments in mice |
| title_full_unstemmed | Protective effects of Astragalus kahiricus root extract on ethanol-induced retrograde memory impairments in mice |
| title_short | Protective effects of Astragalus kahiricus root extract on ethanol-induced retrograde memory impairments in mice |
| title_sort | protective effects of astragalus kahiricus root extract on ethanol induced retrograde memory impairments in mice |
| topic | Alzheimer’s disease Astragalus kahiricus Morris water maze Retrograde memory impairment |
| url | http://herbmedpharmacol.com/PDF/jhp-16387 |
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