Zinc complex based determination of rutin in dietary supplements
The aim of this study was to develop and validate a simple, rapid and sensitive and low-cost method for determination of rutin in tablets. The proposed spectrophotometric method is based on the formation of the Zn2+-rutin complex in 70 v/v% methanol at pH 8.52, and λmax= 410 nm. Linearity range was...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Society of Chemists and Technologists of Macedonia
2016-04-01
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| Series: | Macedonian Journal of Chemistry and Chemical Engineering |
| Subjects: | |
| Online Access: | https://mjcce.org.mk/index.php/MJCCE/article/view/897 |
| _version_ | 1818419729275027456 |
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| author | Leposava Pavun Milena Jelikić Stankov Predrag Đurđević Andrija Ćirić Snezana Uskokovic-Markovic |
| author_facet | Leposava Pavun Milena Jelikić Stankov Predrag Đurđević Andrija Ćirić Snezana Uskokovic-Markovic |
| author_sort | Leposava Pavun |
| collection | DOAJ |
| description | The aim of this study was to develop and validate a simple, rapid and sensitive and low-cost method for determination of rutin in tablets. The proposed spectrophotometric method is based on the formation of the Zn2+-rutin complex in 70 v/v% methanol at pH 8.52, and λmax= 410 nm. Linearity range was defined as 0.3- 12.2 mg mL-1, LOD = 0.21 mg mL-1 and LOQ = 0.63 mg mL-1. The proposed method was successfully applied for determination of rutin in herbal based dietary supplements. The reliability of the method was checked by comparison with results obtained by RP-HPLC/UV method. The proposed method fulfills all aimed requirements. |
| first_indexed | 2024-12-14T12:43:12Z |
| format | Article |
| id | doaj.art-93a35c3901a6493a8a2ef98275893679 |
| institution | Directory Open Access Journal |
| issn | 1857-5552 1857-5625 |
| language | English |
| last_indexed | 2024-12-14T12:43:12Z |
| publishDate | 2016-04-01 |
| publisher | Society of Chemists and Technologists of Macedonia |
| record_format | Article |
| series | Macedonian Journal of Chemistry and Chemical Engineering |
| spelling | doaj.art-93a35c3901a6493a8a2ef982758936792022-12-21T23:00:50ZengSociety of Chemists and Technologists of MacedoniaMacedonian Journal of Chemistry and Chemical Engineering1857-55521857-56252016-04-01351131810.20450/mjcce.2016.897296Zinc complex based determination of rutin in dietary supplementsLeposava Pavun0Milena Jelikić Stankov1Predrag Đurđević2Andrija Ćirić3Snezana Uskokovic-Markovic4University of Belgrade-Faculty of PharmacyUniversity of Belgrade-Faculty of PharmacyFaculty of Science, University of KragujevacFaculty of Science, University of KragujevacUniversity of Belgrade-Faculty of PharmacyThe aim of this study was to develop and validate a simple, rapid and sensitive and low-cost method for determination of rutin in tablets. The proposed spectrophotometric method is based on the formation of the Zn2+-rutin complex in 70 v/v% methanol at pH 8.52, and λmax= 410 nm. Linearity range was defined as 0.3- 12.2 mg mL-1, LOD = 0.21 mg mL-1 and LOQ = 0.63 mg mL-1. The proposed method was successfully applied for determination of rutin in herbal based dietary supplements. The reliability of the method was checked by comparison with results obtained by RP-HPLC/UV method. The proposed method fulfills all aimed requirements.https://mjcce.org.mk/index.php/MJCCE/article/view/897flavonoidsrutin: zinc complex: spectrophotometric determination |
| spellingShingle | Leposava Pavun Milena Jelikić Stankov Predrag Đurđević Andrija Ćirić Snezana Uskokovic-Markovic Zinc complex based determination of rutin in dietary supplements Macedonian Journal of Chemistry and Chemical Engineering flavonoids rutin: zinc complex: spectrophotometric determination |
| title | Zinc complex based determination of rutin in dietary supplements |
| title_full | Zinc complex based determination of rutin in dietary supplements |
| title_fullStr | Zinc complex based determination of rutin in dietary supplements |
| title_full_unstemmed | Zinc complex based determination of rutin in dietary supplements |
| title_short | Zinc complex based determination of rutin in dietary supplements |
| title_sort | zinc complex based determination of rutin in dietary supplements |
| topic | flavonoids rutin: zinc complex: spectrophotometric determination |
| url | https://mjcce.org.mk/index.php/MJCCE/article/view/897 |
| work_keys_str_mv | AT leposavapavun zinccomplexbaseddeterminationofrutinindietarysupplements AT milenajelikicstankov zinccomplexbaseddeterminationofrutinindietarysupplements AT predragđurđevic zinccomplexbaseddeterminationofrutinindietarysupplements AT andrijaciric zinccomplexbaseddeterminationofrutinindietarysupplements AT snezanauskokovicmarkovic zinccomplexbaseddeterminationofrutinindietarysupplements |