Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain
The nutrients and their potential benefits are a new field of study in modern medicine for their positive impact on health. Curcumin, the yellow polyphenolic compound extracted from <i>Curcuma longa</i> species, is widely used in traditional Ayurvedic medicine to prevent and contrast man...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-08-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/16/4794 |
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| author | Tarek Benameur Raffaella Soleti Maria Antonietta Panaro Maria Ester La Torre Vincenzo Monda Giovanni Messina Chiara Porro |
| author_facet | Tarek Benameur Raffaella Soleti Maria Antonietta Panaro Maria Ester La Torre Vincenzo Monda Giovanni Messina Chiara Porro |
| author_sort | Tarek Benameur |
| collection | DOAJ |
| description | The nutrients and their potential benefits are a new field of study in modern medicine for their positive impact on health. Curcumin, the yellow polyphenolic compound extracted from <i>Curcuma longa</i> species, is widely used in traditional Ayurvedic medicine to prevent and contrast many diseases, considering its antioxidant, immunomodulatory, anti-inflammatory, anti-microbial, cardio-protective, nephron-protective, hepato-protective, anti-neoplastic, and anti-rheumatic proprieties. In recent years, the investigations of curcumin have been focused on its application to aging and age-associated diseases. Aging is a physiological process in which there is a decreasing of cellular function due to internal or external stimuli. Oxidative stress is one of the most important causes of aging and age-related diseases. Moreover, many age-related disorders such as cancer, neuroinflammation, and infections are due to a low-grade chronic systemic inflammation. Curcumin acting on different proteins is able to contrast both oxidative stress than inflammation. In the brain, curcumin is able to modulate inflammation induced by microglia. Finally in brain tumors curcumin is able to reduce tumor growth by inhibition of telomerase activity. This review emphasizes the anti-aging role of curcumin focusing on its mechanism to counteract aging in the brain. Moreover, new formulations to increase the bioavailability of curcumin are discussed. |
| first_indexed | 2024-03-10T08:33:21Z |
| format | Article |
| id | doaj.art-93a4112972714c80baba042291f2274f |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T08:33:21Z |
| publishDate | 2021-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-93a4112972714c80baba042291f2274f2023-11-22T08:52:04ZengMDPI AGMolecules1420-30492021-08-012616479410.3390/molecules26164794Curcumin as Prospective Anti-Aging Natural Compound: Focus on BrainTarek Benameur0Raffaella Soleti1Maria Antonietta Panaro2Maria Ester La Torre3Vincenzo Monda4Giovanni Messina5Chiara Porro6Department of Biomedical Sciences, College of Medicine, King Faisal University, Al-Ahsa 31982, Saudi ArabiaUniv Angers, Université de Nantes, Inserm, CRCINA, SFR ICAT, F-49800 Angers, FranceBiotechnologies and Biopharmaceutics, Department of Biosciences, University of Bari, 70125 Bari, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, ItalyDepartment of Clinical and Experimental Medicine, University of Foggia, 71121 Foggia, ItalyThe nutrients and their potential benefits are a new field of study in modern medicine for their positive impact on health. Curcumin, the yellow polyphenolic compound extracted from <i>Curcuma longa</i> species, is widely used in traditional Ayurvedic medicine to prevent and contrast many diseases, considering its antioxidant, immunomodulatory, anti-inflammatory, anti-microbial, cardio-protective, nephron-protective, hepato-protective, anti-neoplastic, and anti-rheumatic proprieties. In recent years, the investigations of curcumin have been focused on its application to aging and age-associated diseases. Aging is a physiological process in which there is a decreasing of cellular function due to internal or external stimuli. Oxidative stress is one of the most important causes of aging and age-related diseases. Moreover, many age-related disorders such as cancer, neuroinflammation, and infections are due to a low-grade chronic systemic inflammation. Curcumin acting on different proteins is able to contrast both oxidative stress than inflammation. In the brain, curcumin is able to modulate inflammation induced by microglia. Finally in brain tumors curcumin is able to reduce tumor growth by inhibition of telomerase activity. This review emphasizes the anti-aging role of curcumin focusing on its mechanism to counteract aging in the brain. Moreover, new formulations to increase the bioavailability of curcumin are discussed.https://www.mdpi.com/1420-3049/26/16/4794curcuminnatural flavonoidanti-agingneuroinflammationtelomerasesantioxidant |
| spellingShingle | Tarek Benameur Raffaella Soleti Maria Antonietta Panaro Maria Ester La Torre Vincenzo Monda Giovanni Messina Chiara Porro Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain Molecules curcumin natural flavonoid anti-aging neuroinflammation telomerases antioxidant |
| title | Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain |
| title_full | Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain |
| title_fullStr | Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain |
| title_full_unstemmed | Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain |
| title_short | Curcumin as Prospective Anti-Aging Natural Compound: Focus on Brain |
| title_sort | curcumin as prospective anti aging natural compound focus on brain |
| topic | curcumin natural flavonoid anti-aging neuroinflammation telomerases antioxidant |
| url | https://www.mdpi.com/1420-3049/26/16/4794 |
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