Real-Life Performance of F-18-FDG PET/CT in Patients with Cervical Lymph Node Metastasis of Unknown Primary Tumor
Background: Neoplasms in the head and neck region possess higher glycolytic activity than normal tissue, showing increased glucose metabolism. F-18-Flourodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) can identify an unknown primary tumor (CUP). Aim: The aim of this stu...
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| Format: | Article |
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MDPI AG
2022-08-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/10/9/2095 |
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| author | Friederike Eilsberger Friederike Elisabeth Noltenius Damiano Librizzi Joel Wessendorf Markus Luster Stephan Hoch Andreas Pfestroff |
| author_facet | Friederike Eilsberger Friederike Elisabeth Noltenius Damiano Librizzi Joel Wessendorf Markus Luster Stephan Hoch Andreas Pfestroff |
| author_sort | Friederike Eilsberger |
| collection | DOAJ |
| description | Background: Neoplasms in the head and neck region possess higher glycolytic activity than normal tissue, showing increased glucose metabolism. F-18-Flourodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) can identify an unknown primary tumor (CUP). Aim: The aim of this study was to assess the real-life performance of F-18-FDG-PET/CT in detecting primary sites in patients with cervical lymph node metastasis of CUP. Methods: A retrospective data analysis of 31 patients who received FDG-PET/CT between June 2009 and March 2015 in a CUP context with histologically confirmed cervical lymph node metastasis was included. Results: In 48% of the patients (15/31), PET/CT showed suspicious tracer accumulation. In 52% of the patients (16/31), there was no suspicious radiotracer uptake, which was confirmed by the lack of identification of any primary tumor in 10 cases until the end of follow-up. FDG-PET/CT had a sensitivity of 67%, specificity of 91%, PPV of 92%, and NPV of 63% in detecting the primary tumor. Additionally, PET/CT showed suspicious tracer accumulation according to further metastasis in 32% of the patients (10/31). Conclusion: FDG-PET/CT imaging is a useful technique for primary tumor detection in patients in a cervical CUP context. Furthermore, it provides information on the ulterior metastasis of the disease. |
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| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T00:40:29Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-93a45535e5d3476490d13b26c2b94d662023-11-23T15:09:05ZengMDPI AGBiomedicines2227-90592022-08-01109209510.3390/biomedicines10092095Real-Life Performance of F-18-FDG PET/CT in Patients with Cervical Lymph Node Metastasis of Unknown Primary TumorFriederike Eilsberger0Friederike Elisabeth Noltenius1Damiano Librizzi2Joel Wessendorf3Markus Luster4Stephan Hoch5Andreas Pfestroff6Department of Nuclear Medicine, University Hospital Marburg, Philipps University Marburg, 35043 Marburg, GermanyDepartment of Nuclear Medicine, University Hospital Marburg, Philipps University Marburg, 35043 Marburg, GermanyDepartment of Nuclear Medicine, University Hospital Marburg, Philipps University Marburg, 35043 Marburg, GermanyDepartment of Nuclear Medicine, University Hospital Marburg, Philipps University Marburg, 35043 Marburg, GermanyDepartment of Nuclear Medicine, University Hospital Marburg, Philipps University Marburg, 35043 Marburg, GermanyDepartment of Otolaryngology, Head and Neck Surgery, University Hospital Marburg, Philipps University Marburg, 35043 Marburg, GermanyDepartment of Nuclear Medicine, University Hospital Marburg, Philipps University Marburg, 35043 Marburg, GermanyBackground: Neoplasms in the head and neck region possess higher glycolytic activity than normal tissue, showing increased glucose metabolism. F-18-Flourodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) can identify an unknown primary tumor (CUP). Aim: The aim of this study was to assess the real-life performance of F-18-FDG-PET/CT in detecting primary sites in patients with cervical lymph node metastasis of CUP. Methods: A retrospective data analysis of 31 patients who received FDG-PET/CT between June 2009 and March 2015 in a CUP context with histologically confirmed cervical lymph node metastasis was included. Results: In 48% of the patients (15/31), PET/CT showed suspicious tracer accumulation. In 52% of the patients (16/31), there was no suspicious radiotracer uptake, which was confirmed by the lack of identification of any primary tumor in 10 cases until the end of follow-up. FDG-PET/CT had a sensitivity of 67%, specificity of 91%, PPV of 92%, and NPV of 63% in detecting the primary tumor. Additionally, PET/CT showed suspicious tracer accumulation according to further metastasis in 32% of the patients (10/31). Conclusion: FDG-PET/CT imaging is a useful technique for primary tumor detection in patients in a cervical CUP context. Furthermore, it provides information on the ulterior metastasis of the disease.https://www.mdpi.com/2227-9059/10/9/2095FDG-PET/CTunknown primary tumorCUPlymph node metastasis |
| spellingShingle | Friederike Eilsberger Friederike Elisabeth Noltenius Damiano Librizzi Joel Wessendorf Markus Luster Stephan Hoch Andreas Pfestroff Real-Life Performance of F-18-FDG PET/CT in Patients with Cervical Lymph Node Metastasis of Unknown Primary Tumor Biomedicines FDG-PET/CT unknown primary tumor CUP lymph node metastasis |
| title | Real-Life Performance of F-18-FDG PET/CT in Patients with Cervical Lymph Node Metastasis of Unknown Primary Tumor |
| title_full | Real-Life Performance of F-18-FDG PET/CT in Patients with Cervical Lymph Node Metastasis of Unknown Primary Tumor |
| title_fullStr | Real-Life Performance of F-18-FDG PET/CT in Patients with Cervical Lymph Node Metastasis of Unknown Primary Tumor |
| title_full_unstemmed | Real-Life Performance of F-18-FDG PET/CT in Patients with Cervical Lymph Node Metastasis of Unknown Primary Tumor |
| title_short | Real-Life Performance of F-18-FDG PET/CT in Patients with Cervical Lymph Node Metastasis of Unknown Primary Tumor |
| title_sort | real life performance of f 18 fdg pet ct in patients with cervical lymph node metastasis of unknown primary tumor |
| topic | FDG-PET/CT unknown primary tumor CUP lymph node metastasis |
| url | https://www.mdpi.com/2227-9059/10/9/2095 |
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