Subjective and Objective Outcomes in Patients With COPD After Pulmonary Rehabilitation – The Impact of Comorbidities
Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with multiple systemic manifestations and comorbidities, which contribute independently to its total morbidity and mortality. Pulmonary rehabilitation is an evidence-based intervention that is indicated for COPD pati...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2019-03-01
|
| Series: | Frontiers in Physiology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fphys.2019.00286/full |
| _version_ | 1818172367950577664 |
|---|---|
| author | Maria Charikiopoulou Maria Charikiopoulou Pantelis Theodoros Nikolaidis Beat Knechtle Thomas Rosemann Aggeliki Rapti Aggeliki Rapti Georgia Trakada |
| author_facet | Maria Charikiopoulou Maria Charikiopoulou Pantelis Theodoros Nikolaidis Beat Knechtle Thomas Rosemann Aggeliki Rapti Aggeliki Rapti Georgia Trakada |
| author_sort | Maria Charikiopoulou |
| collection | DOAJ |
| description | Background: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with multiple systemic manifestations and comorbidities, which contribute independently to its total morbidity and mortality. Pulmonary rehabilitation is an evidence-based intervention that is indicated for COPD patients who remain symptomatic, despite optimal pharmacological therapy. Although it is well documented in pure COPD, the role of pulmonary rehabilitation is uncertain in coexisting comorbidities. The aim of the present study was to clarify the effect of a pulmonary rehabilitation program in COPD patients with concomitant comorbidities.Methods: Thirty two patients with COPD were evaluated before and after a comprehensive pulmonary rehabilitation program, in terms of dyspnea, quality of life (QOL), pulmonary function tests and exercise capacity. The patients were also divided into two groups, according to the presence or the absence of comorbidities. Patients with none or only one comorbidity (Group 1, n = 11) were compared to those who had two or more comorbidities (Group 2, n = 21).Results: All patients significantly improved in dyspnea, as expressed by modified Medical Research Council scale and the COPD assessment Test (p < 0.001), QOL as assessed by the St. George respiratory questionnaire (p < 0.001) and exercise tolerance in six minute walking test (p < 0.001). Peak oxygen uptake relatively increased and body mass decreased in Group 1 compared to Group 2 (p < 0.05).Conclusion: Pulmonary rehabilitation in COPD seems to be beneficial for all patients, independently of the presence, the number or the nature of their comorbidities. Thus, the presence of comorbidities must not represent an exclusion criterion for patients that are referred to pulmonary rehabilitation programs.Trial Registration: Current controlled trials ISRCTN14648515 Retrospectively registered 15 February 2018. |
| first_indexed | 2024-12-11T19:11:30Z |
| format | Article |
| id | doaj.art-93a4c29701554bf4b2e101fb6b1862aa |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-12-11T19:11:30Z |
| publishDate | 2019-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-93a4c29701554bf4b2e101fb6b1862aa2022-12-22T00:53:45ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2019-03-011010.3389/fphys.2019.00286422674Subjective and Objective Outcomes in Patients With COPD After Pulmonary Rehabilitation – The Impact of ComorbiditiesMaria Charikiopoulou0Maria Charikiopoulou1Pantelis Theodoros Nikolaidis2Beat Knechtle3Thomas Rosemann4Aggeliki Rapti5Aggeliki Rapti6Georgia Trakada7Pulmonary Rehabilitation Department, General Hospital for Chest Diseases of Athens “SOTIRIA”, Athens, Greece2nd Pulmonary Department, General Hospital for Chest Diseases of Athens “SOTIRIA”, Athens, GreeceExercise Physiology Laboratory, Nikaia, GreeceInstitute of Primary Care, University of Zurich, Zurich, SwitzerlandInstitute of Primary Care, University of Zurich, Zurich, SwitzerlandPulmonary Rehabilitation Department, General Hospital for Chest Diseases of Athens “SOTIRIA”, Athens, Greece2nd Pulmonary Department, General Hospital for Chest Diseases of Athens “SOTIRIA”, Athens, GreeceDivision of Pulmonology, Department of Clinical Therapeutics, School of Medicine, Alexandra Hospital, National and Kapodistrian University of Athens, Athens, GreeceBackground: Chronic obstructive pulmonary disease (COPD) is a heterogeneous disease with multiple systemic manifestations and comorbidities, which contribute independently to its total morbidity and mortality. Pulmonary rehabilitation is an evidence-based intervention that is indicated for COPD patients who remain symptomatic, despite optimal pharmacological therapy. Although it is well documented in pure COPD, the role of pulmonary rehabilitation is uncertain in coexisting comorbidities. The aim of the present study was to clarify the effect of a pulmonary rehabilitation program in COPD patients with concomitant comorbidities.Methods: Thirty two patients with COPD were evaluated before and after a comprehensive pulmonary rehabilitation program, in terms of dyspnea, quality of life (QOL), pulmonary function tests and exercise capacity. The patients were also divided into two groups, according to the presence or the absence of comorbidities. Patients with none or only one comorbidity (Group 1, n = 11) were compared to those who had two or more comorbidities (Group 2, n = 21).Results: All patients significantly improved in dyspnea, as expressed by modified Medical Research Council scale and the COPD assessment Test (p < 0.001), QOL as assessed by the St. George respiratory questionnaire (p < 0.001) and exercise tolerance in six minute walking test (p < 0.001). Peak oxygen uptake relatively increased and body mass decreased in Group 1 compared to Group 2 (p < 0.05).Conclusion: Pulmonary rehabilitation in COPD seems to be beneficial for all patients, independently of the presence, the number or the nature of their comorbidities. Thus, the presence of comorbidities must not represent an exclusion criterion for patients that are referred to pulmonary rehabilitation programs.Trial Registration: Current controlled trials ISRCTN14648515 Retrospectively registered 15 February 2018.https://www.frontiersin.org/article/10.3389/fphys.2019.00286/fulldyspneaquality of lifesix minute walking testcardiopulmonary exercise testlung disease |
| spellingShingle | Maria Charikiopoulou Maria Charikiopoulou Pantelis Theodoros Nikolaidis Beat Knechtle Thomas Rosemann Aggeliki Rapti Aggeliki Rapti Georgia Trakada Subjective and Objective Outcomes in Patients With COPD After Pulmonary Rehabilitation – The Impact of Comorbidities Frontiers in Physiology dyspnea quality of life six minute walking test cardiopulmonary exercise test lung disease |
| title | Subjective and Objective Outcomes in Patients With COPD After Pulmonary Rehabilitation – The Impact of Comorbidities |
| title_full | Subjective and Objective Outcomes in Patients With COPD After Pulmonary Rehabilitation – The Impact of Comorbidities |
| title_fullStr | Subjective and Objective Outcomes in Patients With COPD After Pulmonary Rehabilitation – The Impact of Comorbidities |
| title_full_unstemmed | Subjective and Objective Outcomes in Patients With COPD After Pulmonary Rehabilitation – The Impact of Comorbidities |
| title_short | Subjective and Objective Outcomes in Patients With COPD After Pulmonary Rehabilitation – The Impact of Comorbidities |
| title_sort | subjective and objective outcomes in patients with copd after pulmonary rehabilitation the impact of comorbidities |
| topic | dyspnea quality of life six minute walking test cardiopulmonary exercise test lung disease |
| url | https://www.frontiersin.org/article/10.3389/fphys.2019.00286/full |
| work_keys_str_mv | AT mariacharikiopoulou subjectiveandobjectiveoutcomesinpatientswithcopdafterpulmonaryrehabilitationtheimpactofcomorbidities AT mariacharikiopoulou subjectiveandobjectiveoutcomesinpatientswithcopdafterpulmonaryrehabilitationtheimpactofcomorbidities AT pantelistheodorosnikolaidis subjectiveandobjectiveoutcomesinpatientswithcopdafterpulmonaryrehabilitationtheimpactofcomorbidities AT beatknechtle subjectiveandobjectiveoutcomesinpatientswithcopdafterpulmonaryrehabilitationtheimpactofcomorbidities AT thomasrosemann subjectiveandobjectiveoutcomesinpatientswithcopdafterpulmonaryrehabilitationtheimpactofcomorbidities AT aggelikirapti subjectiveandobjectiveoutcomesinpatientswithcopdafterpulmonaryrehabilitationtheimpactofcomorbidities AT aggelikirapti subjectiveandobjectiveoutcomesinpatientswithcopdafterpulmonaryrehabilitationtheimpactofcomorbidities AT georgiatrakada subjectiveandobjectiveoutcomesinpatientswithcopdafterpulmonaryrehabilitationtheimpactofcomorbidities |