Implications of High Sensitivity Troponin Levels After Lung Transplantation
Trends in high-sensitivity cardiac troponin I (hs-cTnI) after lung transplant (LT) and its clinical value are not well stablished. This study aimed to determine kinetics of hs-cTnI after LT, factors impacting hs-cTnI and clinical outcomes. LT recipients from 2015 to 2017 at Toronto General Hospital...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-04-01
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| Series: | Transplant International |
| Subjects: | |
| Online Access: | https://www.frontierspartnerships.org/articles/10.3389/ti.2024.12724/full |
| _version_ | 1797214970445824000 |
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| author | Eduard Rodenas-Alesina Eduard Rodenas-Alesina Adriana Luk Adriana Luk John Gajasan Anhar Alhussaini Anhar Alhussaini Genevieve Martel Cyril Serrick Karen McRae Chris Overgaard Marcelo Cypel Marcelo Cypel Lianne Singer Lianne Singer Jussi Tikkanen Jussi Tikkanen Shaf Keshavjee Shaf Keshavjee Lorenzo Del Sorbo Lorenzo Del Sorbo Lorenzo Del Sorbo |
| author_facet | Eduard Rodenas-Alesina Eduard Rodenas-Alesina Adriana Luk Adriana Luk John Gajasan Anhar Alhussaini Anhar Alhussaini Genevieve Martel Cyril Serrick Karen McRae Chris Overgaard Marcelo Cypel Marcelo Cypel Lianne Singer Lianne Singer Jussi Tikkanen Jussi Tikkanen Shaf Keshavjee Shaf Keshavjee Lorenzo Del Sorbo Lorenzo Del Sorbo Lorenzo Del Sorbo |
| author_sort | Eduard Rodenas-Alesina |
| collection | DOAJ |
| description | Trends in high-sensitivity cardiac troponin I (hs-cTnI) after lung transplant (LT) and its clinical value are not well stablished. This study aimed to determine kinetics of hs-cTnI after LT, factors impacting hs-cTnI and clinical outcomes. LT recipients from 2015 to 2017 at Toronto General Hospital were included. Hs-cTnI levels were collected at 0–24 h, 24–48 h and 48–72 h after LT. The primary outcome was invasive mechanical ventilation (IMV) >3 days. 206 patients received a LT (median age 58, 35.4% women; 79.6% double LT). All patients but one fulfilled the criteria for postoperative myocardial infarction (median peak hs-cTnI = 4,820 ng/mL). Peak hs-cTnI correlated with right ventricular dysfunction, >1 red blood cell transfusions, bilateral LT, use of EVLP, kidney function at admission and time on CPB or VA-ECMO. IMV>3 days occurred in 91 (44.2%) patients, and peak hs-cTnI was higher in these patients (3,823 vs. 6,429 ng/mL, p < 0.001 after adjustment). Peak hs-cTnI was higher among patients with had atrial arrhythmias or died during admission. No patients underwent revascularization. In summary, peak hs-TnI is determined by recipient comorbidities and perioperative factors, and not by coronary artery disease. Hs-cTnI captures patients at higher risk for prolonged IMV, atrial arrhythmias and in-hospital death. |
| first_indexed | 2024-04-24T11:22:38Z |
| format | Article |
| id | doaj.art-93a52cfa44724bdeae85a15df2a7fcd4 |
| institution | Directory Open Access Journal |
| issn | 1432-2277 |
| language | English |
| last_indexed | 2024-04-24T11:22:38Z |
| publishDate | 2024-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Transplant International |
| spelling | doaj.art-93a52cfa44724bdeae85a15df2a7fcd42024-04-11T04:11:18ZengFrontiers Media S.A.Transplant International1432-22772024-04-013710.3389/ti.2024.1272412724Implications of High Sensitivity Troponin Levels After Lung TransplantationEduard Rodenas-Alesina0Eduard Rodenas-Alesina1Adriana Luk2Adriana Luk3John Gajasan4Anhar Alhussaini5Anhar Alhussaini6Genevieve Martel7Cyril Serrick8Karen McRae9Chris Overgaard10Marcelo Cypel11Marcelo Cypel12Lianne Singer13Lianne Singer14Jussi Tikkanen15Jussi Tikkanen16Shaf Keshavjee17Shaf Keshavjee18Lorenzo Del Sorbo19Lorenzo Del Sorbo20Lorenzo Del Sorbo21Division of Cardiology, Department of Medicine, University of Toronto, Toronto, ON, CanadaTed Rogers Centre for Heart Research, Peter Munk Cardiac Centre, University Health Network, Toronto, ON, CanadaDivision of Cardiology, Department of Medicine, University of Toronto, Toronto, ON, CanadaTed Rogers Centre for Heart Research, Peter Munk Cardiac Centre, University Health Network, Toronto, ON, CanadaInterdepartmental Division of Critical Care Medicine, University Health Network, Toronto, ON, CanadaDivision of Cardiology, Department of Medicine, University of Toronto, Toronto, ON, CanadaTed Rogers Centre for Heart Research, Peter Munk Cardiac Centre, University Health Network, Toronto, ON, CanadaPerfusion Services, University Health Network, Toronto, ON, CanadaPerfusion Services, University Health Network, Toronto, ON, CanadaDepartment of Anesthesia and Pain Management, University Health Network, Toronto, ON, CanadaSouthlake Regional Healthcare Centre, Newmarket, ON, CanadaDivision of Thoracic Surgery, Faculty of Surgery, University of Toronto, Toronto, ON, CanadaToronto Lung Transplant Program, Ajmera Transplant Center, University Health Network, Toronto, ON, CanadaToronto Lung Transplant Program, Ajmera Transplant Center, University Health Network, Toronto, ON, CanadaDivision of Respirology, Faculty of Medicine, University of Toronto, Toronto, ON, CanadaToronto Lung Transplant Program, Ajmera Transplant Center, University Health Network, Toronto, ON, CanadaDivision of Respirology, Faculty of Medicine, University of Toronto, Toronto, ON, CanadaDivision of Thoracic Surgery, Faculty of Surgery, University of Toronto, Toronto, ON, CanadaToronto Lung Transplant Program, Ajmera Transplant Center, University Health Network, Toronto, ON, CanadaInterdepartmental Division of Critical Care Medicine, University Health Network, Toronto, ON, CanadaToronto Lung Transplant Program, Ajmera Transplant Center, University Health Network, Toronto, ON, CanadaDivision of Respirology, Faculty of Medicine, University of Toronto, Toronto, ON, CanadaTrends in high-sensitivity cardiac troponin I (hs-cTnI) after lung transplant (LT) and its clinical value are not well stablished. This study aimed to determine kinetics of hs-cTnI after LT, factors impacting hs-cTnI and clinical outcomes. LT recipients from 2015 to 2017 at Toronto General Hospital were included. Hs-cTnI levels were collected at 0–24 h, 24–48 h and 48–72 h after LT. The primary outcome was invasive mechanical ventilation (IMV) >3 days. 206 patients received a LT (median age 58, 35.4% women; 79.6% double LT). All patients but one fulfilled the criteria for postoperative myocardial infarction (median peak hs-cTnI = 4,820 ng/mL). Peak hs-cTnI correlated with right ventricular dysfunction, >1 red blood cell transfusions, bilateral LT, use of EVLP, kidney function at admission and time on CPB or VA-ECMO. IMV>3 days occurred in 91 (44.2%) patients, and peak hs-cTnI was higher in these patients (3,823 vs. 6,429 ng/mL, p < 0.001 after adjustment). Peak hs-cTnI was higher among patients with had atrial arrhythmias or died during admission. No patients underwent revascularization. In summary, peak hs-TnI is determined by recipient comorbidities and perioperative factors, and not by coronary artery disease. Hs-cTnI captures patients at higher risk for prolonged IMV, atrial arrhythmias and in-hospital death.https://www.frontierspartnerships.org/articles/10.3389/ti.2024.12724/fulllung transplanttroponinprimary graft dysfunctionmechanical ventilationarrhythmia |
| spellingShingle | Eduard Rodenas-Alesina Eduard Rodenas-Alesina Adriana Luk Adriana Luk John Gajasan Anhar Alhussaini Anhar Alhussaini Genevieve Martel Cyril Serrick Karen McRae Chris Overgaard Marcelo Cypel Marcelo Cypel Lianne Singer Lianne Singer Jussi Tikkanen Jussi Tikkanen Shaf Keshavjee Shaf Keshavjee Lorenzo Del Sorbo Lorenzo Del Sorbo Lorenzo Del Sorbo Implications of High Sensitivity Troponin Levels After Lung Transplantation Transplant International lung transplant troponin primary graft dysfunction mechanical ventilation arrhythmia |
| title | Implications of High Sensitivity Troponin Levels After Lung Transplantation |
| title_full | Implications of High Sensitivity Troponin Levels After Lung Transplantation |
| title_fullStr | Implications of High Sensitivity Troponin Levels After Lung Transplantation |
| title_full_unstemmed | Implications of High Sensitivity Troponin Levels After Lung Transplantation |
| title_short | Implications of High Sensitivity Troponin Levels After Lung Transplantation |
| title_sort | implications of high sensitivity troponin levels after lung transplantation |
| topic | lung transplant troponin primary graft dysfunction mechanical ventilation arrhythmia |
| url | https://www.frontierspartnerships.org/articles/10.3389/ti.2024.12724/full |
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