Well‐differentiated liposarcoma of tongue: A case report
Key Clinical Message It is important to consider WDLS as a potential cause of tongue lesions and include it in the list of differential diagnoses. When performing surgical intervention, it is crucial to remove enough tissue around the lesion, and regular follow‐up is necessary due to the high risk o...
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Clinical Case Reports |
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| Online Access: | https://doi.org/10.1002/ccr3.8237 |
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| author | Moushami Singh Arun R. Napit Gunja Piya Prabhat Chandra Thakur Sambit Mohanty Sayali Shinde Ekta Jain Hari Prasad Dhakal |
| author_facet | Moushami Singh Arun R. Napit Gunja Piya Prabhat Chandra Thakur Sambit Mohanty Sayali Shinde Ekta Jain Hari Prasad Dhakal |
| author_sort | Moushami Singh |
| collection | DOAJ |
| description | Key Clinical Message It is important to consider WDLS as a potential cause of tongue lesions and include it in the list of differential diagnoses. When performing surgical intervention, it is crucial to remove enough tissue around the lesion, and regular follow‐up is necessary due to the high risk of recurrence, despite its rarity, when margins are positive. Abstract Liposarcoma (LS) is the most common soft tissue sarcomas (STSs) that arise from embryonic mesenchymal tissue. Though these sarcomas commonly arise at retroperitoneal locations and extremities, the appearance of these tumors in the head and neck region is rare, with the tongue as a preferred site. As per WHO 2020, LS is classified into four subtypes based on morphology, namely, Well‐differentiated liposarcoma (WDLS), Dedifferentiated liposarcoma (DDLS), Myxoid liposarcoma (MLS), and Pleomorphic liposarcoma (PLS). WLS is the most common variant among all. Here, we had a case of 55 years old male with the complaint of swelling in the left lateral border of the tongue with the preliminary diagnosis of pleomorphic adenoma. The patient underwent a left partial glossectomy with adequate margins. Further evaluation of the lesion revealed a clear cell tumor that was ultimately confirmed as liposarcoma on immunohistochemistry that showed tumor cells positive for S100, CDK4, and MDM2 with 2% Ki‐67. Postsurgical status of the patient was evaluated by F18 FDG PET CTscan, which was normal. Currently, the patient is under regular follow‐up. |
| first_indexed | 2024-03-09T14:29:56Z |
| format | Article |
| id | doaj.art-93a6113f14f24c2cb1a8f9007f329088 |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-03-09T14:29:56Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-93a6113f14f24c2cb1a8f9007f3290882023-11-28T04:14:45ZengWileyClinical Case Reports2050-09042023-11-011111n/an/a10.1002/ccr3.8237Well‐differentiated liposarcoma of tongue: A case reportMoushami Singh0Arun R. Napit1Gunja Piya2Prabhat Chandra Thakur3Sambit Mohanty4Sayali Shinde5Ekta Jain6Hari Prasad Dhakal7Department of Pathology and Laboratory Medicine Nepal Cancer Hospital and Research Center Lalitpur NepalDepartment of Pathology and Laboratory Medicine Nepal Cancer Hospital and Research Center Lalitpur NepalDepartment of Pathology and Laboratory Medicine Nepal Cancer Hospital and Research Center Lalitpur NepalDepartment of Head and Neck Surgical Oncology Nepal Cancer Hospital and Research Center Lalitpur NepalCore Diagnostics National reference Lab Gurugram IndiaCore Diagnostics National reference Lab Gurugram IndiaCore Diagnostics National reference Lab Gurugram IndiaDepartment of Pathology and Laboratory Medicine Nepal Cancer Hospital and Research Center Lalitpur NepalKey Clinical Message It is important to consider WDLS as a potential cause of tongue lesions and include it in the list of differential diagnoses. When performing surgical intervention, it is crucial to remove enough tissue around the lesion, and regular follow‐up is necessary due to the high risk of recurrence, despite its rarity, when margins are positive. Abstract Liposarcoma (LS) is the most common soft tissue sarcomas (STSs) that arise from embryonic mesenchymal tissue. Though these sarcomas commonly arise at retroperitoneal locations and extremities, the appearance of these tumors in the head and neck region is rare, with the tongue as a preferred site. As per WHO 2020, LS is classified into four subtypes based on morphology, namely, Well‐differentiated liposarcoma (WDLS), Dedifferentiated liposarcoma (DDLS), Myxoid liposarcoma (MLS), and Pleomorphic liposarcoma (PLS). WLS is the most common variant among all. Here, we had a case of 55 years old male with the complaint of swelling in the left lateral border of the tongue with the preliminary diagnosis of pleomorphic adenoma. The patient underwent a left partial glossectomy with adequate margins. Further evaluation of the lesion revealed a clear cell tumor that was ultimately confirmed as liposarcoma on immunohistochemistry that showed tumor cells positive for S100, CDK4, and MDM2 with 2% Ki‐67. Postsurgical status of the patient was evaluated by F18 FDG PET CTscan, which was normal. Currently, the patient is under regular follow‐up.https://doi.org/10.1002/ccr3.8237liposarcomapleomorphic adenomatonguewell differentiated |
| spellingShingle | Moushami Singh Arun R. Napit Gunja Piya Prabhat Chandra Thakur Sambit Mohanty Sayali Shinde Ekta Jain Hari Prasad Dhakal Well‐differentiated liposarcoma of tongue: A case report Clinical Case Reports liposarcoma pleomorphic adenoma tongue well differentiated |
| title | Well‐differentiated liposarcoma of tongue: A case report |
| title_full | Well‐differentiated liposarcoma of tongue: A case report |
| title_fullStr | Well‐differentiated liposarcoma of tongue: A case report |
| title_full_unstemmed | Well‐differentiated liposarcoma of tongue: A case report |
| title_short | Well‐differentiated liposarcoma of tongue: A case report |
| title_sort | well differentiated liposarcoma of tongue a case report |
| topic | liposarcoma pleomorphic adenoma tongue well differentiated |
| url | https://doi.org/10.1002/ccr3.8237 |
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