Efficacy and safety of chemoradiation therapy using one-shot cisplatin via hepatic arterial infusion for advanced hepatocellular carcinoma with major macrovascular invasion: a single-arm retrospective cohort study
Abstract Background Patients with hepatocellular carcinoma (HCC) and macrovascular invasion (MVI) who receive systemic chemotherapy have a poor prognosis. This study aimed to determine if one-shot cisplatin (CDDP) chemotherapy via hepatic arterial infusion (HAI) combined with radiation therapy (RT)...
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
BMC
2022-06-01
|
Series: | BMC Gastroenterology |
Subjects: | |
Online Access: | https://doi.org/10.1186/s12876-022-02359-x |
_version_ | 1818553453221249024 |
---|---|
author | Kensuke Naruto Tomokazu Kawaoka Kenichiro Kodama Yutaro Ogawa Kei Amioka Yuki Yoshikawa Chihiro Kikukawa Yousuke Suehiro Kenji Yamaoka Yuwa Ando Yumi Kosaka Shinsuke Uchikawa Takashi Nakahara Eisuke Murakami Atsushi Ono Takuro Uchida Masami Yamauchi Wataru Okamoto Shoichi Takahashi Michio Imamura Keigo Chosa Kazuo Awai Katsumaro Kubo Yasushi Nagata Kazuaki Chayama Hiroshi Aikata |
author_facet | Kensuke Naruto Tomokazu Kawaoka Kenichiro Kodama Yutaro Ogawa Kei Amioka Yuki Yoshikawa Chihiro Kikukawa Yousuke Suehiro Kenji Yamaoka Yuwa Ando Yumi Kosaka Shinsuke Uchikawa Takashi Nakahara Eisuke Murakami Atsushi Ono Takuro Uchida Masami Yamauchi Wataru Okamoto Shoichi Takahashi Michio Imamura Keigo Chosa Kazuo Awai Katsumaro Kubo Yasushi Nagata Kazuaki Chayama Hiroshi Aikata |
author_sort | Kensuke Naruto |
collection | DOAJ |
description | Abstract Background Patients with hepatocellular carcinoma (HCC) and macrovascular invasion (MVI) who receive systemic chemotherapy have a poor prognosis. This study aimed to determine if one-shot cisplatin (CDDP) chemotherapy via hepatic arterial infusion (HAI) combined with radiation therapy (RT) prior to systemic chemotherapy could improve the outcomes of these patients. Methods This study consisted of 32 HCC patients with the following eligibility criteria: (i) portal vein invasion 3/4 and/or hepatic vein invasion 2/3; (ii) received one-shot CDDP via HAI; (iii) received RT for MVI, (iv) a Child–Pugh score ≤ 7; and (v) an Eastern Clinical Oncology Group Performance Status score of 0 or 1. To determine the therapeutic effect, we collected information on patient characteristics and took contrast-enhanced computed tomography at the start of the therapy and every 2 to 4 months after the start of therapy. We evaluated the overall response of the tumor and tumor thrombosis according to modified Response Evaluation Criteria in Solid Tumors. We assessed patient data using the Mann–Whitney U and Fisher exact tests and evaluated overall survival and progression-free survival using the log-rank test. Results The overall response rate at the first evaluation performed a median of 1.4 weeks after HAI was 16% for the main intrahepatic tumor and 59% for the MVI. The best responses were the same as those of the first-time responses. The duration of median survival was 8.6 months, and progression-free survival of the main intrahepatic tumor was 3.2 months. Predictive factors for overall survival were the relative tumor volume in the liver and the first therapeutic response of MVI. There were no severe adverse events or radiation-induced hepatic complications. Conclusions One-shot CDDP via HAI and RT were well tolerated and showed immediate and favorable control of MVI. Thus, this combination shows potential as a bridging therapy to systemic chemotherapy. |
first_indexed | 2024-12-12T09:26:01Z |
format | Article |
id | doaj.art-93a7ea8c43054f84af8a2d302d0c6ab0 |
institution | Directory Open Access Journal |
issn | 1471-230X |
language | English |
last_indexed | 2024-12-12T09:26:01Z |
publishDate | 2022-06-01 |
publisher | BMC |
record_format | Article |
series | BMC Gastroenterology |
spelling | doaj.art-93a7ea8c43054f84af8a2d302d0c6ab02022-12-22T00:29:02ZengBMCBMC Gastroenterology1471-230X2022-06-0122111010.1186/s12876-022-02359-xEfficacy and safety of chemoradiation therapy using one-shot cisplatin via hepatic arterial infusion for advanced hepatocellular carcinoma with major macrovascular invasion: a single-arm retrospective cohort studyKensuke Naruto0Tomokazu Kawaoka1Kenichiro Kodama2Yutaro Ogawa3Kei Amioka4Yuki Yoshikawa5Chihiro Kikukawa6Yousuke Suehiro7Kenji Yamaoka8Yuwa Ando9Yumi Kosaka10Shinsuke Uchikawa11Takashi Nakahara12Eisuke Murakami13Atsushi Ono14Takuro Uchida15Masami Yamauchi16Wataru Okamoto17Shoichi Takahashi18Michio Imamura19Keigo Chosa20Kazuo Awai21Katsumaro Kubo22Yasushi Nagata23Kazuaki Chayama24Hiroshi Aikata25Department of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityDiagnostic Radiology, Hiroshima UniversityDiagnostic Radiology, Hiroshima UniversityTherapeutic Radiology, Institute and Graduate School of Biomedical Sciences, Hiroshima UniversityTherapeutic Radiology, Institute and Graduate School of Biomedical Sciences, Hiroshima UniversityResearch Center for Hepatology and Gastroenterology, Hiroshima UniversityDepartment of Gastroenterology and Metabolism, Hiroshima UniversityAbstract Background Patients with hepatocellular carcinoma (HCC) and macrovascular invasion (MVI) who receive systemic chemotherapy have a poor prognosis. This study aimed to determine if one-shot cisplatin (CDDP) chemotherapy via hepatic arterial infusion (HAI) combined with radiation therapy (RT) prior to systemic chemotherapy could improve the outcomes of these patients. Methods This study consisted of 32 HCC patients with the following eligibility criteria: (i) portal vein invasion 3/4 and/or hepatic vein invasion 2/3; (ii) received one-shot CDDP via HAI; (iii) received RT for MVI, (iv) a Child–Pugh score ≤ 7; and (v) an Eastern Clinical Oncology Group Performance Status score of 0 or 1. To determine the therapeutic effect, we collected information on patient characteristics and took contrast-enhanced computed tomography at the start of the therapy and every 2 to 4 months after the start of therapy. We evaluated the overall response of the tumor and tumor thrombosis according to modified Response Evaluation Criteria in Solid Tumors. We assessed patient data using the Mann–Whitney U and Fisher exact tests and evaluated overall survival and progression-free survival using the log-rank test. Results The overall response rate at the first evaluation performed a median of 1.4 weeks after HAI was 16% for the main intrahepatic tumor and 59% for the MVI. The best responses were the same as those of the first-time responses. The duration of median survival was 8.6 months, and progression-free survival of the main intrahepatic tumor was 3.2 months. Predictive factors for overall survival were the relative tumor volume in the liver and the first therapeutic response of MVI. There were no severe adverse events or radiation-induced hepatic complications. Conclusions One-shot CDDP via HAI and RT were well tolerated and showed immediate and favorable control of MVI. Thus, this combination shows potential as a bridging therapy to systemic chemotherapy.https://doi.org/10.1186/s12876-022-02359-xHepatocellular carcinomaMacrovascular invasionHepatic arterial infusion chemotherapyRadiation therapy |
spellingShingle | Kensuke Naruto Tomokazu Kawaoka Kenichiro Kodama Yutaro Ogawa Kei Amioka Yuki Yoshikawa Chihiro Kikukawa Yousuke Suehiro Kenji Yamaoka Yuwa Ando Yumi Kosaka Shinsuke Uchikawa Takashi Nakahara Eisuke Murakami Atsushi Ono Takuro Uchida Masami Yamauchi Wataru Okamoto Shoichi Takahashi Michio Imamura Keigo Chosa Kazuo Awai Katsumaro Kubo Yasushi Nagata Kazuaki Chayama Hiroshi Aikata Efficacy and safety of chemoradiation therapy using one-shot cisplatin via hepatic arterial infusion for advanced hepatocellular carcinoma with major macrovascular invasion: a single-arm retrospective cohort study BMC Gastroenterology Hepatocellular carcinoma Macrovascular invasion Hepatic arterial infusion chemotherapy Radiation therapy |
title | Efficacy and safety of chemoradiation therapy using one-shot cisplatin via hepatic arterial infusion for advanced hepatocellular carcinoma with major macrovascular invasion: a single-arm retrospective cohort study |
title_full | Efficacy and safety of chemoradiation therapy using one-shot cisplatin via hepatic arterial infusion for advanced hepatocellular carcinoma with major macrovascular invasion: a single-arm retrospective cohort study |
title_fullStr | Efficacy and safety of chemoradiation therapy using one-shot cisplatin via hepatic arterial infusion for advanced hepatocellular carcinoma with major macrovascular invasion: a single-arm retrospective cohort study |
title_full_unstemmed | Efficacy and safety of chemoradiation therapy using one-shot cisplatin via hepatic arterial infusion for advanced hepatocellular carcinoma with major macrovascular invasion: a single-arm retrospective cohort study |
title_short | Efficacy and safety of chemoradiation therapy using one-shot cisplatin via hepatic arterial infusion for advanced hepatocellular carcinoma with major macrovascular invasion: a single-arm retrospective cohort study |
title_sort | efficacy and safety of chemoradiation therapy using one shot cisplatin via hepatic arterial infusion for advanced hepatocellular carcinoma with major macrovascular invasion a single arm retrospective cohort study |
topic | Hepatocellular carcinoma Macrovascular invasion Hepatic arterial infusion chemotherapy Radiation therapy |
url | https://doi.org/10.1186/s12876-022-02359-x |
work_keys_str_mv | AT kensukenaruto efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT tomokazukawaoka efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT kenichirokodama efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT yutaroogawa efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT keiamioka efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT yukiyoshikawa efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT chihirokikukawa efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT yousukesuehiro efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT kenjiyamaoka efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT yuwaando efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT yumikosaka efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT shinsukeuchikawa efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT takashinakahara efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT eisukemurakami efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT atsushiono efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT takurouchida efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT masamiyamauchi efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT wataruokamoto efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT shoichitakahashi efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT michioimamura efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT keigochosa efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT kazuoawai efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT katsumarokubo efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT yasushinagata efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT kazuakichayama efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy AT hiroshiaikata efficacyandsafetyofchemoradiationtherapyusingoneshotcisplatinviahepaticarterialinfusionforadvancedhepatocellularcarcinomawithmajormacrovascularinvasionasinglearmretrospectivecohortstudy |