Clonality of CD4+ Blood T Cells Predicts Longer Survival With CTLA4 or PD-1 Checkpoint Inhibition in Advanced Melanoma

Clonality of CD4+ Blood T Cells Predicts Longer Survival With CTLA4 or PD-1 Checkpoint Inhibition in Advanced Melanoma

Recognition of cancer antigens drives the clonal expansion of cancer-reactive T cells, which is thought to contribute to restricted T-cell receptor (TCR) repertoires in tumor-infiltrating lymphocytes (TILs). To understand how tumors escape anti-tumor immunity, we investigated tumor-associated T-cell...

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Bibliographic Details
Main Authors: Akiko Arakawa, Sigrid Vollmer, Julia Tietze, Adrian Galinski, Markus V. Heppt, Maja Bürdek, Carola Berking, Jörg C. Prinz
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-06-01
Series:Frontiers in Immunology
Subjects:
anti-tumor immunity
checkpoint inhibitor
CTLA4
melanoma
T cell clone
TCR
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.01336/full

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