Targeted Overexpression of <i>Claudin 11</i> in Osteoblasts Increases Trabecular Bone Mass by Stimulating Osteogenesis at the Expense of Adipogenesis in Mice

Targeted Overexpression of <i>Claudin 11</i> in Osteoblasts Increases Trabecular Bone Mass by Stimulating Osteogenesis at the Expense of Adipogenesis in Mice

Mice lacking <i>Claudin11</i> (<i>Cldn11</i>) manifest reduced trabecular bone mass. However, the impact of <i>Cldn11</i> expression in osteoblasts in vivo remains understudied. Herein, we generated osteoblast-specific transgenic (Tg) mice expressing <i>Cldn...

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Bibliographic Details
Main Authors: Weirong Xing, Sheila Pourteymoor, Anakha Udayakumar, Yian Chen, Subburaman Mohan
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Biology
Subjects:
Claudin11
overexpression
bone formation
transgenic
adipogenesis
osteogenesis
Online Access:https://www.mdpi.com/2079-7737/13/2/108

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