Recent developments in the probiotics as live biotherapeutic products (LBPs) as modulators of gut brain axis related neurological conditions
Abstract Probiotics have been defined as “living microorganisms that create health benefits in the host when taken in sufficient amounts. Recent developments in the understanding of the relationship between the microbiom and its host have shown evidence about the promising potential of probiotics to...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-10-01
|
| Series: | Journal of Translational Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12967-022-03609-y |
| _version_ | 1797996161246691328 |
|---|---|
| author | Duygu Ağagündüz Feray Gençer Bingöl Elif Çelik Özge Cemali Çiler Özenir Fatih Özoğul Raffaele Capasso |
| author_facet | Duygu Ağagündüz Feray Gençer Bingöl Elif Çelik Özge Cemali Çiler Özenir Fatih Özoğul Raffaele Capasso |
| author_sort | Duygu Ağagündüz |
| collection | DOAJ |
| description | Abstract Probiotics have been defined as “living microorganisms that create health benefits in the host when taken in sufficient amounts. Recent developments in the understanding of the relationship between the microbiom and its host have shown evidence about the promising potential of probiotics to improve certain health problems. However, today, there are some confusions about traditional and new generation foods containing probiotics, naming and classifications of them in scientific studies and also their marketing. To clarify this confusion, the Food and Drug Administration (FDA) declared that it has made a new category definition called "live biotherapeutic products" (LBPs). Accordingly, the FDA has designated LBPs as “a biological product that: i)contains live organisms, such as bacteria; ii)is applicable to the prevention, treatment, or cure of a disease/condition of human beings; and iii) is not a vaccine”. The accumulated literature focused on LBPs to determine effective strains in health and disease, and often focused on obesity, diabetes, and certain diseases like inflammatory bowel disease (IBD).However, microbiome also play an important role in the pathogenesis of diseases that age day by day in the modern world via gut-brain axis. Herein, we discuss the novel roles of LBPs in some gut-brain axis related conditions in the light of recent studies. This article may be of interest to a broad readership including those interested in probiotics as LBPs, their health effects and safety, also gut-brain axis. |
| first_indexed | 2024-04-11T10:13:03Z |
| format | Article |
| id | doaj.art-93b1b61929b54e7bb7693a06d5ab2249 |
| institution | Directory Open Access Journal |
| issn | 1479-5876 |
| language | English |
| last_indexed | 2024-04-11T10:13:03Z |
| publishDate | 2022-10-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Translational Medicine |
| spelling | doaj.art-93b1b61929b54e7bb7693a06d5ab22492022-12-22T04:30:03ZengBMCJournal of Translational Medicine1479-58762022-10-0120112610.1186/s12967-022-03609-yRecent developments in the probiotics as live biotherapeutic products (LBPs) as modulators of gut brain axis related neurological conditionsDuygu Ağagündüz0Feray Gençer Bingöl1Elif Çelik2Özge Cemali3Çiler Özenir4Fatih Özoğul5Raffaele Capasso6Department of Nutrition and Dietetics, Gazi University, Faculty of Health SciencesDepartment of Nutrition and Dietetics, Burdur Mehmet Akif Ersoy UniversityDepartment of Nutrition and Dietetics, Gazi University, Faculty of Health SciencesDepartment of Nutrition and Dietetics, Gazi University, Faculty of Health SciencesDepartment of Nutrition and Dietetics, Kırıkkale UniversityDepartment of Seafood Processing Technology, Faculty of Fisheries, Cukurova UniversityDepartment of Agricultural Sciences, University of Naples Federico IIAbstract Probiotics have been defined as “living microorganisms that create health benefits in the host when taken in sufficient amounts. Recent developments in the understanding of the relationship between the microbiom and its host have shown evidence about the promising potential of probiotics to improve certain health problems. However, today, there are some confusions about traditional and new generation foods containing probiotics, naming and classifications of them in scientific studies and also their marketing. To clarify this confusion, the Food and Drug Administration (FDA) declared that it has made a new category definition called "live biotherapeutic products" (LBPs). Accordingly, the FDA has designated LBPs as “a biological product that: i)contains live organisms, such as bacteria; ii)is applicable to the prevention, treatment, or cure of a disease/condition of human beings; and iii) is not a vaccine”. The accumulated literature focused on LBPs to determine effective strains in health and disease, and often focused on obesity, diabetes, and certain diseases like inflammatory bowel disease (IBD).However, microbiome also play an important role in the pathogenesis of diseases that age day by day in the modern world via gut-brain axis. Herein, we discuss the novel roles of LBPs in some gut-brain axis related conditions in the light of recent studies. This article may be of interest to a broad readership including those interested in probiotics as LBPs, their health effects and safety, also gut-brain axis.https://doi.org/10.1186/s12967-022-03609-yProbioticsLive biotherapeutic products (LBPs)Gut brain axisNeurodegenerative diseasesSafety |
| spellingShingle | Duygu Ağagündüz Feray Gençer Bingöl Elif Çelik Özge Cemali Çiler Özenir Fatih Özoğul Raffaele Capasso Recent developments in the probiotics as live biotherapeutic products (LBPs) as modulators of gut brain axis related neurological conditions Journal of Translational Medicine Probiotics Live biotherapeutic products (LBPs) Gut brain axis Neurodegenerative diseases Safety |
| title | Recent developments in the probiotics as live biotherapeutic products (LBPs) as modulators of gut brain axis related neurological conditions |
| title_full | Recent developments in the probiotics as live biotherapeutic products (LBPs) as modulators of gut brain axis related neurological conditions |
| title_fullStr | Recent developments in the probiotics as live biotherapeutic products (LBPs) as modulators of gut brain axis related neurological conditions |
| title_full_unstemmed | Recent developments in the probiotics as live biotherapeutic products (LBPs) as modulators of gut brain axis related neurological conditions |
| title_short | Recent developments in the probiotics as live biotherapeutic products (LBPs) as modulators of gut brain axis related neurological conditions |
| title_sort | recent developments in the probiotics as live biotherapeutic products lbps as modulators of gut brain axis related neurological conditions |
| topic | Probiotics Live biotherapeutic products (LBPs) Gut brain axis Neurodegenerative diseases Safety |
| url | https://doi.org/10.1186/s12967-022-03609-y |
| work_keys_str_mv | AT duyguagagunduz recentdevelopmentsintheprobioticsaslivebiotherapeuticproductslbpsasmodulatorsofgutbrainaxisrelatedneurologicalconditions AT feraygencerbingol recentdevelopmentsintheprobioticsaslivebiotherapeuticproductslbpsasmodulatorsofgutbrainaxisrelatedneurologicalconditions AT elifcelik recentdevelopmentsintheprobioticsaslivebiotherapeuticproductslbpsasmodulatorsofgutbrainaxisrelatedneurologicalconditions AT ozgecemali recentdevelopmentsintheprobioticsaslivebiotherapeuticproductslbpsasmodulatorsofgutbrainaxisrelatedneurologicalconditions AT cilerozenir recentdevelopmentsintheprobioticsaslivebiotherapeuticproductslbpsasmodulatorsofgutbrainaxisrelatedneurologicalconditions AT fatihozogul recentdevelopmentsintheprobioticsaslivebiotherapeuticproductslbpsasmodulatorsofgutbrainaxisrelatedneurologicalconditions AT raffaelecapasso recentdevelopmentsintheprobioticsaslivebiotherapeuticproductslbpsasmodulatorsofgutbrainaxisrelatedneurologicalconditions |