GCF Resistin As A Novel Marker in Patients with Chronic Periodontitis and Rheumatoid Arthritis
Background: The associational studies between periodontitis and rheumatoid arthritis are less documented, although they are found to have similar inflammatory pathogenesis. Resistin, a novel adipokine is suggested to be a common link between periodontitis and rheumatoid arthritis. The aim of the...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
JCDR Research and Publications Private Limited
2015-04-01
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| Series: | Journal of Clinical and Diagnostic Research |
| Subjects: | |
| Online Access: | https://jcdr.net/articles/PDF/5849/12327_CE[Ra1]_F(AK)_PF1(PAK)_PFA(AK)_PF2(PAG).pdf |
| Summary: | Background: The associational studies between periodontitis
and rheumatoid arthritis are less documented, although
they are found to have similar inflammatory pathogenesis.
Resistin, a novel adipokine is suggested to be a common link
between periodontitis and rheumatoid arthritis. The aim of the
present study was to reinforce the inter-relationship between
periodontitis and rheumatoid arthritis by using resistin as a
potent inflammatory marker.
Materials and Methods: Hundred patients (aged >30 y) of
either sex were selected for this study and were divided equally
into four groups of 25 patients each. Group A consisted of
healthy individuals, Group B consisted of patients with chronic
periodontitis, Group C of patients with rheumatoid arthritis
and Group D had patients suffering from both arthritis and
periodontitis. Periodontal parameters assessed were plaque
index (PI), modified gingival index (GI) and probing depth (PD).
Panoramic radiographs were taken to confirm the diagnosis
of periodontitis. Rheumatoid arthritis was confirmed by the
rheumatologists and seropositivity for rheumatoid factor (RF)
was checked. Resistin levels were analysed in GCF collected
from all the four groups and statistical analysis was done by
using Pearson correlation coefficient.
Results: The GCF of all the patients showed presence of resistin.
The level of resistin was highest in Group D patients and least
in Group A patients. On analysing the samples together positive
co-relation was found between GCF resistin and PD, PI, GI and
RF.
Conclusion: Resistin levels are increased in both chronic
periodontitis and rheumatoid arthritis. Therefore, the increased
level of GCF resistin can be regarded as potential inflammatory
marker for periodontitis and rheumatoid arthritis. |
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| ISSN: | 2249-782X 0973-709X |