Occult Vertebral Fracture (OVF) in Patients Who Underwent Hepatectomy for Colorectal Liver Metastasis: Strong Association with Oncological Outcomes
Aim: The impact of occult vertebral fracture (OVF) on oncological outcomes after surgery has not been investigated, although its significance in orthopedics has been much debated recently. We evaluated the prognostic significance of OVF on the long-term outcomes of patients with colorectal liver met...
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MDPI AG
2023-11-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/15/23/5513 |
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| author | Kenei Furukawa Koichiro Haruki Tomohiko Taniai Mitsuru Yanagaki Masashi Tsunematsu Yoshiaki Tanji Shunta Ishizaki Yoshihiro Shirai Shinji Onda Toru Ikegami |
| author_facet | Kenei Furukawa Koichiro Haruki Tomohiko Taniai Mitsuru Yanagaki Masashi Tsunematsu Yoshiaki Tanji Shunta Ishizaki Yoshihiro Shirai Shinji Onda Toru Ikegami |
| author_sort | Kenei Furukawa |
| collection | DOAJ |
| description | Aim: The impact of occult vertebral fracture (OVF) on oncological outcomes after surgery has not been investigated, although its significance in orthopedics has been much debated recently. We evaluated the prognostic significance of OVF on the long-term outcomes of patients with colorectal liver metastases (CRLM) after hepatectomy. Methods: We included 140 patients with CRLM who underwent hepatectomy. OVF was identified using quantitative measurement and preoperative sagittal computed tomography image reconstruction from the 11th thoracic vertebra to the 5th lumber vertebra. Results: OVF was identified in 48 (34%) of the patients. In multivariate analysis, lymph node metastases (<i>p</i> < 0.01), multiple tumors (<i>p</i> = 0.02), extrahepatic lesions (<i>p</i> < 0.01), OVF (<i>p</i> < 0.01), intraoperative bleeding (<i>p</i> = 0.04), and curability 1 or 2 (<i>p</i> < 0.01) were independent and significant predictors of disease-free survival and extrahepatic lesions (<i>p</i> < 0.01), osteosarcopenia (<i>p</i> = 0.02), and OVF (<i>p</i> < 0.01) were independent and significant predictors of overall survival. A higher age, adjuvant chemotherapy for a primary lesion before metachronous liver metastases, osteopenia, and hypoalbuminemia were independent risk factors for OVF. Conclusions: The evaluation of preoperative OVF is a useful prognostic factor for risk stratification and clinical decision-making for patients with CRLM. |
| first_indexed | 2024-03-09T01:54:56Z |
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| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-09T01:54:56Z |
| publishDate | 2023-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-93bd3d1eb2574629bbc566971c34c6cb2023-12-08T15:12:23ZengMDPI AGCancers2072-66942023-11-011523551310.3390/cancers15235513Occult Vertebral Fracture (OVF) in Patients Who Underwent Hepatectomy for Colorectal Liver Metastasis: Strong Association with Oncological OutcomesKenei Furukawa0Koichiro Haruki1Tomohiko Taniai2Mitsuru Yanagaki3Masashi Tsunematsu4Yoshiaki Tanji5Shunta Ishizaki6Yoshihiro Shirai7Shinji Onda8Toru Ikegami9Division of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, JapanDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, JapanDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, JapanDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, JapanDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, JapanDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, JapanDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, JapanDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, JapanDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, JapanDivision of Hepatobiliary and Pancreas Surgery, Department of Surgery, The Jikei University School of Medicine, 3-25-8, Nishi-Shinbashi, Minato-ku, Tokyo 105-8461, JapanAim: The impact of occult vertebral fracture (OVF) on oncological outcomes after surgery has not been investigated, although its significance in orthopedics has been much debated recently. We evaluated the prognostic significance of OVF on the long-term outcomes of patients with colorectal liver metastases (CRLM) after hepatectomy. Methods: We included 140 patients with CRLM who underwent hepatectomy. OVF was identified using quantitative measurement and preoperative sagittal computed tomography image reconstruction from the 11th thoracic vertebra to the 5th lumber vertebra. Results: OVF was identified in 48 (34%) of the patients. In multivariate analysis, lymph node metastases (<i>p</i> < 0.01), multiple tumors (<i>p</i> = 0.02), extrahepatic lesions (<i>p</i> < 0.01), OVF (<i>p</i> < 0.01), intraoperative bleeding (<i>p</i> = 0.04), and curability 1 or 2 (<i>p</i> < 0.01) were independent and significant predictors of disease-free survival and extrahepatic lesions (<i>p</i> < 0.01), osteosarcopenia (<i>p</i> = 0.02), and OVF (<i>p</i> < 0.01) were independent and significant predictors of overall survival. A higher age, adjuvant chemotherapy for a primary lesion before metachronous liver metastases, osteopenia, and hypoalbuminemia were independent risk factors for OVF. Conclusions: The evaluation of preoperative OVF is a useful prognostic factor for risk stratification and clinical decision-making for patients with CRLM.https://www.mdpi.com/2072-6694/15/23/5513occult vertebral fractureOVFsarcopeniaosteopeniaosteosarcopeniacolorectal liver metastases |
| spellingShingle | Kenei Furukawa Koichiro Haruki Tomohiko Taniai Mitsuru Yanagaki Masashi Tsunematsu Yoshiaki Tanji Shunta Ishizaki Yoshihiro Shirai Shinji Onda Toru Ikegami Occult Vertebral Fracture (OVF) in Patients Who Underwent Hepatectomy for Colorectal Liver Metastasis: Strong Association with Oncological Outcomes Cancers occult vertebral fracture OVF sarcopenia osteopenia osteosarcopenia colorectal liver metastases |
| title | Occult Vertebral Fracture (OVF) in Patients Who Underwent Hepatectomy for Colorectal Liver Metastasis: Strong Association with Oncological Outcomes |
| title_full | Occult Vertebral Fracture (OVF) in Patients Who Underwent Hepatectomy for Colorectal Liver Metastasis: Strong Association with Oncological Outcomes |
| title_fullStr | Occult Vertebral Fracture (OVF) in Patients Who Underwent Hepatectomy for Colorectal Liver Metastasis: Strong Association with Oncological Outcomes |
| title_full_unstemmed | Occult Vertebral Fracture (OVF) in Patients Who Underwent Hepatectomy for Colorectal Liver Metastasis: Strong Association with Oncological Outcomes |
| title_short | Occult Vertebral Fracture (OVF) in Patients Who Underwent Hepatectomy for Colorectal Liver Metastasis: Strong Association with Oncological Outcomes |
| title_sort | occult vertebral fracture ovf in patients who underwent hepatectomy for colorectal liver metastasis strong association with oncological outcomes |
| topic | occult vertebral fracture OVF sarcopenia osteopenia osteosarcopenia colorectal liver metastases |
| url | https://www.mdpi.com/2072-6694/15/23/5513 |
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