Antinociceptive Effect of Hydro-alcoholic Extract of Biophytum Sensivitum Leaf on Adult Male Rat
BACKGROUND AND OBJECTIVE: Medicinal plants as the rich source of efficient compounds are largely used worldwide especially to treat pain and inflammatory processes by the population in traditional medicine. The aim of this study was to investigate the antinociceptive effect of hydro-alcoholic extract...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Babol University of Medical Sciences
2014-10-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| Subjects: | |
| Online Access: | http://jbums.org/browse.php?a_code=A-10-583-5&slc_lang=en&sid=1 |
| Summary: | BACKGROUND AND OBJECTIVE: Medicinal plants as the rich source of
efficient compounds are largely used worldwide especially to treat pain and
inflammatory processes by the population in traditional medicine. The aim of
this study was to investigate the antinociceptive effect of hydro-alcoholic extract
of Biophytum sensivitum leaf on male rats.
METHODS: In this study,
42 adult male rats were divided into 7 groups: Control, groups treated with the
extract (80, 100 and 300mg/kg, i.p.), Morphine
(1mg/kg, i.p.), Aspirin (1mg/kg, i.p.), and Naloxone (1mg/kg, i.p.) with a dose
of 300mg/kg. The analgesic effects of extract
were assessed with Writhing, Tail-flick and Formalin tests.
FINDINGS: Hydro-alcoholic extract of Biophytum sensivitum
leaf at dose of 300mg/kg clearly indicated the antinociceptive effect in Writhing
(with 30 decrease), tail-flick (3/9 seconds increase) with p<0.01 and
chronic phase of formalin (decrease of pain score from 2 to 0/6) (p<0.001)
tests. The results showed that there was no significant difference
between the morphine and receiving extract (300mg/kg) groups in the
chronic phase of formalin. In addition, LD50 of plant extract was
3400mg/kg.
CONCLUSION: This study suggested that the hydro-alcoholic extract
of Biophytum sensivitum leaf had the antinociceptive effects on both acute and chronic
pains. |
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| ISSN: | 1561-4107 2251-7170 |