Antinociceptive Effect of Hydro-alcoholic Extract of Biophytum Sensivitum Leaf on Adult Male Rat
BACKGROUND AND OBJECTIVE: Medicinal plants as the rich source of efficient compounds are largely used worldwide especially to treat pain and inflammatory processes by the population in traditional medicine. The aim of this study was to investigate the antinociceptive effect of hydro-alcoholic extract...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Babol University of Medical Sciences
2014-10-01
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| Series: | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| Subjects: | |
| Online Access: | http://jbums.org/browse.php?a_code=A-10-583-5&slc_lang=en&sid=1 |
| _version_ | 1818502619766718464 |
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| author | Minoo Mahmoodi Saeed Mohammadi Afagh Yavari |
| author_facet | Minoo Mahmoodi Saeed Mohammadi Afagh Yavari |
| author_sort | Minoo Mahmoodi |
| collection | DOAJ |
| description | BACKGROUND AND OBJECTIVE: Medicinal plants as the rich source of
efficient compounds are largely used worldwide especially to treat pain and
inflammatory processes by the population in traditional medicine. The aim of
this study was to investigate the antinociceptive effect of hydro-alcoholic extract
of Biophytum sensivitum leaf on male rats.
METHODS: In this study,
42 adult male rats were divided into 7 groups: Control, groups treated with the
extract (80, 100 and 300mg/kg, i.p.), Morphine
(1mg/kg, i.p.), Aspirin (1mg/kg, i.p.), and Naloxone (1mg/kg, i.p.) with a dose
of 300mg/kg. The analgesic effects of extract
were assessed with Writhing, Tail-flick and Formalin tests.
FINDINGS: Hydro-alcoholic extract of Biophytum sensivitum
leaf at dose of 300mg/kg clearly indicated the antinociceptive effect in Writhing
(with 30 decrease), tail-flick (3/9 seconds increase) with p<0.01 and
chronic phase of formalin (decrease of pain score from 2 to 0/6) (p<0.001)
tests. The results showed that there was no significant difference
between the morphine and receiving extract (300mg/kg) groups in the
chronic phase of formalin. In addition, LD50 of plant extract was
3400mg/kg.
CONCLUSION: This study suggested that the hydro-alcoholic extract
of Biophytum sensivitum leaf had the antinociceptive effects on both acute and chronic
pains. |
| first_indexed | 2024-12-10T21:12:40Z |
| format | Article |
| id | doaj.art-93bd609acb8d41e9ba44b6450e32bb06 |
| institution | Directory Open Access Journal |
| issn | 1561-4107 2251-7170 |
| language | English |
| last_indexed | 2024-12-10T21:12:40Z |
| publishDate | 2014-10-01 |
| publisher | Babol University of Medical Sciences |
| record_format | Article |
| series | Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul |
| spelling | doaj.art-93bd609acb8d41e9ba44b6450e32bb062022-12-22T01:33:25ZengBabol University of Medical SciencesMajallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul1561-41072251-71702014-10-0116103137Antinociceptive Effect of Hydro-alcoholic Extract of Biophytum Sensivitum Leaf on Adult Male RatMinoo Mahmoodi0Saeed Mohammadi1Afagh Yavari2 BACKGROUND AND OBJECTIVE: Medicinal plants as the rich source of efficient compounds are largely used worldwide especially to treat pain and inflammatory processes by the population in traditional medicine. The aim of this study was to investigate the antinociceptive effect of hydro-alcoholic extract of Biophytum sensivitum leaf on male rats. METHODS: In this study, 42 adult male rats were divided into 7 groups: Control, groups treated with the extract (80, 100 and 300mg/kg, i.p.), Morphine (1mg/kg, i.p.), Aspirin (1mg/kg, i.p.), and Naloxone (1mg/kg, i.p.) with a dose of 300mg/kg. The analgesic effects of extract were assessed with Writhing, Tail-flick and Formalin tests. FINDINGS: Hydro-alcoholic extract of Biophytum sensivitum leaf at dose of 300mg/kg clearly indicated the antinociceptive effect in Writhing (with 30 decrease), tail-flick (3/9 seconds increase) with p<0.01 and chronic phase of formalin (decrease of pain score from 2 to 0/6) (p<0.001) tests. The results showed that there was no significant difference between the morphine and receiving extract (300mg/kg) groups in the chronic phase of formalin. In addition, LD50 of plant extract was 3400mg/kg. CONCLUSION: This study suggested that the hydro-alcoholic extract of Biophytum sensivitum leaf had the antinociceptive effects on both acute and chronic pains.http://jbums.org/browse.php?a_code=A-10-583-5&slc_lang=en&sid=1KEY WORDS: Hydro-alcoholic extractAntinociceptionBiophytum sensivitumFormalin |
| spellingShingle | Minoo Mahmoodi Saeed Mohammadi Afagh Yavari Antinociceptive Effect of Hydro-alcoholic Extract of Biophytum Sensivitum Leaf on Adult Male Rat Majallah-i Dānishgāh-i ̒Ulūm-i Pizishkī-i Bābul KEY WORDS: Hydro-alcoholic extract Antinociception Biophytum sensivitum Formalin |
| title | Antinociceptive Effect of Hydro-alcoholic Extract of Biophytum Sensivitum Leaf on Adult Male Rat |
| title_full | Antinociceptive Effect of Hydro-alcoholic Extract of Biophytum Sensivitum Leaf on Adult Male Rat |
| title_fullStr | Antinociceptive Effect of Hydro-alcoholic Extract of Biophytum Sensivitum Leaf on Adult Male Rat |
| title_full_unstemmed | Antinociceptive Effect of Hydro-alcoholic Extract of Biophytum Sensivitum Leaf on Adult Male Rat |
| title_short | Antinociceptive Effect of Hydro-alcoholic Extract of Biophytum Sensivitum Leaf on Adult Male Rat |
| title_sort | antinociceptive effect of hydro alcoholic extract of biophytum sensivitum leaf on adult male rat |
| topic | KEY WORDS: Hydro-alcoholic extract Antinociception Biophytum sensivitum Formalin |
| url | http://jbums.org/browse.php?a_code=A-10-583-5&slc_lang=en&sid=1 |
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