Risk Factors and Survival Outcomes for Patients With Anastomotic Leakage After Surgery for Head and Neck Squamous Cell Carcinoma
ObjectivesThis study evaluated the risk factors for anastomotic leakage (AL) and survival outcomes in patients with head and neck squamous cell carcinoma (HNSCC).MethodsPatients with HNSCC who underwent surgery carrying potential AL from 2003 through 2009 were included in this study. Univariate and...
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| Format: | Article |
| Language: | English |
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Korean Society of Otorhinolaryngology-Head and Neck Surgery
2014-03-01
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| Series: | Clinical and Experimental Otorhinolaryngology |
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| Online Access: | http://www.e-ceo.org/upload/pdf/ceo-7-36.pdf |
| _version_ | 1818278493523279872 |
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| author | Do-Youn Kim Jong-Lyel Roh Jong Woo Choi Seung-Ho Choi Soon Yuhl Nam Sang Yoon Kim |
| author_facet | Do-Youn Kim Jong-Lyel Roh Jong Woo Choi Seung-Ho Choi Soon Yuhl Nam Sang Yoon Kim |
| author_sort | Do-Youn Kim |
| collection | DOAJ |
| description | ObjectivesThis study evaluated the risk factors for anastomotic leakage (AL) and survival outcomes in patients with head and neck squamous cell carcinoma (HNSCC).MethodsPatients with HNSCC who underwent surgery carrying potential AL from 2003 through 2009 were included in this study. Univariate and multivariate analyses were performed and patient survival was calculated by the Kaplan-Meier method.ResultsOf 232 eligible patients, 25 (10.8%) developed AL. Univariate analyses revealed that primary tumor site, salvage surgery, perineural invasion, radiotherapy, chemotherapy, and blood transfusion were significantly associated with the occurrence of AL (P<0.05). Independent risk factors for AL were salvage surgery and blood transfusion (P<0.01). On univariate analysis, AL was significantly associated with overall (OS) and disease-free survivals (DFS; P<0.05) but not with decreased locoregional control (LRC) rate (P=0.07). The 5-year DFS rate was significantly different between the non-leakage and leakage groups (70.9% vs. 27.7%, P<0.001). Multivariate analysis showed, however, that AL was not an independent variable of LRC, DFS, or OS (P>0.1).ConclusionPatients who received salvage surgery and blood transfusion may require careful surveillance for development of AL, which has a tendency toward decreased survival. |
| first_indexed | 2024-12-12T23:18:19Z |
| format | Article |
| id | doaj.art-93c2abec9c654aa9ae7e516b240864ad |
| institution | Directory Open Access Journal |
| issn | 1976-8710 2005-0720 |
| language | English |
| last_indexed | 2024-12-12T23:18:19Z |
| publishDate | 2014-03-01 |
| publisher | Korean Society of Otorhinolaryngology-Head and Neck Surgery |
| record_format | Article |
| series | Clinical and Experimental Otorhinolaryngology |
| spelling | doaj.art-93c2abec9c654aa9ae7e516b240864ad2022-12-22T00:08:22ZengKorean Society of Otorhinolaryngology-Head and Neck SurgeryClinical and Experimental Otorhinolaryngology1976-87102005-07202014-03-0171364110.3342/ceo.2014.7.1.36333Risk Factors and Survival Outcomes for Patients With Anastomotic Leakage After Surgery for Head and Neck Squamous Cell CarcinomaDo-Youn Kim0Jong-Lyel Roh1Jong Woo Choi2Seung-Ho Choi3Soon Yuhl Nam4Sang Yoon Kim5Department of Otolaryngology, Asan Meidcal Center, University of Ulsan College of Medicine, Seoul, Korea.Department of Otolaryngology, Asan Meidcal Center, University of Ulsan College of Medicine, Seoul, Korea.Department of Plastic and Reconstructive Surgery, Asan Meidcal Center, University of Ulsan College of Medicine, Seoul, Korea.Department of Otolaryngology, Asan Meidcal Center, University of Ulsan College of Medicine, Seoul, Korea.Department of Otolaryngology, Asan Meidcal Center, University of Ulsan College of Medicine, Seoul, Korea.Department of Otolaryngology, Asan Meidcal Center, University of Ulsan College of Medicine, Seoul, Korea.ObjectivesThis study evaluated the risk factors for anastomotic leakage (AL) and survival outcomes in patients with head and neck squamous cell carcinoma (HNSCC).MethodsPatients with HNSCC who underwent surgery carrying potential AL from 2003 through 2009 were included in this study. Univariate and multivariate analyses were performed and patient survival was calculated by the Kaplan-Meier method.ResultsOf 232 eligible patients, 25 (10.8%) developed AL. Univariate analyses revealed that primary tumor site, salvage surgery, perineural invasion, radiotherapy, chemotherapy, and blood transfusion were significantly associated with the occurrence of AL (P<0.05). Independent risk factors for AL were salvage surgery and blood transfusion (P<0.01). On univariate analysis, AL was significantly associated with overall (OS) and disease-free survivals (DFS; P<0.05) but not with decreased locoregional control (LRC) rate (P=0.07). The 5-year DFS rate was significantly different between the non-leakage and leakage groups (70.9% vs. 27.7%, P<0.001). Multivariate analysis showed, however, that AL was not an independent variable of LRC, DFS, or OS (P>0.1).ConclusionPatients who received salvage surgery and blood transfusion may require careful surveillance for development of AL, which has a tendency toward decreased survival.http://www.e-ceo.org/upload/pdf/ceo-7-36.pdfAnastomotic leakageHead and neck squamous cell carcinomaSurvivalRisk factor |
| spellingShingle | Do-Youn Kim Jong-Lyel Roh Jong Woo Choi Seung-Ho Choi Soon Yuhl Nam Sang Yoon Kim Risk Factors and Survival Outcomes for Patients With Anastomotic Leakage After Surgery for Head and Neck Squamous Cell Carcinoma Clinical and Experimental Otorhinolaryngology Anastomotic leakage Head and neck squamous cell carcinoma Survival Risk factor |
| title | Risk Factors and Survival Outcomes for Patients With Anastomotic Leakage After Surgery for Head and Neck Squamous Cell Carcinoma |
| title_full | Risk Factors and Survival Outcomes for Patients With Anastomotic Leakage After Surgery for Head and Neck Squamous Cell Carcinoma |
| title_fullStr | Risk Factors and Survival Outcomes for Patients With Anastomotic Leakage After Surgery for Head and Neck Squamous Cell Carcinoma |
| title_full_unstemmed | Risk Factors and Survival Outcomes for Patients With Anastomotic Leakage After Surgery for Head and Neck Squamous Cell Carcinoma |
| title_short | Risk Factors and Survival Outcomes for Patients With Anastomotic Leakage After Surgery for Head and Neck Squamous Cell Carcinoma |
| title_sort | risk factors and survival outcomes for patients with anastomotic leakage after surgery for head and neck squamous cell carcinoma |
| topic | Anastomotic leakage Head and neck squamous cell carcinoma Survival Risk factor |
| url | http://www.e-ceo.org/upload/pdf/ceo-7-36.pdf |
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