The SARS-CoV-2 main protease induces neurotoxic TDP-43 cleavage and aggregates

The SARS-CoV-2 main protease induces neurotoxic TDP-43 cleavage and aggregates

Bibliographic Details
Main Authors:	Jiaxin Yang, Yan Li, Shijin Wang, Huili Li, Lili Zhang, Haichen Zhang, Pei-Hui Wang, Xiangyu Zheng, Xiao-Fang Yu, Wei Wei
Format:	Article
Language:	English
Published:	Nature Publishing Group 2023-03-01
Series:	Signal Transduction and Targeted Therapy
Online Access:	https://doi.org/10.1038/s41392-023-01386-8

Similar Items

DCTN1 Binds to TDP-43 and Regulates TDP-43 Aggregation
by: Manami Deshimaru, et al.
Published: (2021-04-01)

p62 overexpression induces TDP-43 cytoplasmic mislocalisation, aggregation and cleavage and neuronal death
by: A. D. Foster, et al.
Published: (2021-06-01)

The cooperative binding of TDP-43 to GU-rich RNA repeats antagonizes TDP-43 aggregation
by: Juan Carlos Rengifo-Gonzalez, et al.
Published: (2021-09-01)

TDP-43 causes neurotoxicity and cytoskeletal dysfunction in primary cortical neurons.
by: Pranetha Baskaran, et al.
Published: (2018-01-01)

The Role of HDAC6 in TDP-43-Induced Neurotoxicity and UPS Impairment
by: Shinrye Lee, et al.
Published: (2020-11-01)

Endolysosomal pathway activity protects cells from neurotoxic TDP-43
by: Christine Leibiger, et al.
Published: (2018-03-01)

TDP-43 and Limbic-Predominant Age-Related TDP-43 Encephalopathy
by: Lumi Zhang, et al.
Published: (2020-01-01)

Inflammation Induces TDP-43 Mislocalization and Aggregation.
by: Ana Sofia Correia, et al.
Published: (2015-01-01)

Aberrant TDP‐43 phosphorylation: a key wind gap from TDP‐43 to TDP‐43 proteinopathy
by: Zi‐Qi Huang, et al.
Published: (2021-06-01)

Restoring functional TDP-43 oligomers in ALS and laminopathic cellular models through baicalein-induced reconfiguration of TDP-43 aggregates
by: Hsiang-Yu Chang, et al.
Published: (2024-02-01)

TDP-43 promotes tau accumulation and selective neurotoxicity in bigenic Caenorhabditis elegans
by: Caitlin S. Latimer, et al.
Published: (2022-04-01)

Cytotoxic immune cells do not affect TDP-43 and p62 sarcoplasmic aggregation but influence TDP-43 localisation
by: Bryony McCord, et al.
Published: (2023-09-01)

The aggregation and neurotoxicity of TDP-43 and its ALS-associated 25 kDa fragment are differentially affected by molecular chaperones in Drosophila.
by: Jenna M Gregory, et al.
Published: (2012-01-01)

Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies
by: Laetitia Miguel, et al.
Published: (2011-02-01)

Phosphorylated TDP-43 (pTDP-43) aggregates in the axial skeletal muscle of patients with sporadic and familial amyotrophic lateral sclerosis
by: Matthew D. Cykowski, et al.
Published: (2018-04-01)

Age-dependent neurodegeneration and organelle transport deficiencies in mutant TDP43 patient-derived neurons are independent of TDP43 aggregation
by: N. Kreiter, et al.
Published: (2018-07-01)

Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43
by: Qiang Zhang, et al.
Published: (2022-08-01)

Halogen doped graphene quantum dots modulate TDP-43 phase separation and aggregation in the nucleus
by: Hong Zhang, et al.
Published: (2024-04-01)

High glycine content in TDP-43: a potential culprit in limbic-predominant age-related TDP-43 encephalopathy
by: Shanshan An, et al.
Published: (2020-06-01)

A C-Terminally Truncated TDP-43 Splice Isoform Exhibits Neuronal Specific Cytoplasmic Aggregation and Contributes to TDP-43 Pathology in ALS
by: Marc Shenouda, et al.
Published: (2022-06-01)

BAG6 prevents the aggregation of neurodegeneration-associated fragments of TDP43
by: Yasar Arfat T. Kasu, et al.
Published: (2022-05-01)

Electrostatic Repulsion Governs TDP-43 C-terminal Domain Aggregation.
by: Miguel Mompeán, et al.
Published: (2016-04-01)

The pathological phenotypes of human TDP-43 transgenic mouse models are independent of downregulation of mouse Tdp-43.
by: Ya-Fei Xu, et al.
Published: (2013-01-01)

A 43-kDa TDP-43 species is present in aggregates associated with frontotemporal lobar degeneration.
by: Patrick J Bosque, et al.
Published: (2013-01-01)

LIPIDS ALTERATION IN TDP-43
by: Irene García Toledo, et al.
Published: (2023-10-01)

Liquid–Liquid Phase Separation Enhances TDP-43 LCD Aggregation but Delays Seeded Aggregation
by: Donya Pakravan, et al.
Published: (2021-04-01)

TDP-43: From Alzheimer’s Disease to Limbic-Predominant Age-Related TDP-43 Encephalopathy
by: Wendi Huang, et al.
Published: (2020-02-01)

TDP-43 mislocalization drives neurofilament changes in a novel model of TDP-43 proteinopathy
by: Rachel Atkinson, et al.
Published: (2021-02-01)

Evidence of cerebellar TDP-43 loss of function in FTLD-TDP
by: Sarah Pickles, et al.
Published: (2022-07-01)

Stress Granule Assembly Can Facilitate but Is Not Required for TDP-43 Cytoplasmic Aggregation
by: Nikita Fernandes, et al.
Published: (2020-09-01)

Aggregation of TDP-43 fragments triggers cellular aberrant function: implication in neurodegeneration
by: Che Meixia, et al.
Published: (2012-02-01)

Prion-like Properties of Pathological TDP-43 Aggregates from Diseased Brains
by: Takashi Nonaka, et al.
Published: (2013-07-01)

Cytoplasmic accumulation and aggregation of TDP-43 upon proteasome inhibition in cultured neurons.
by: Janet van Eersel, et al.
Published: (2011-01-01)

TDP-43 expression influences amyloidβ plaque deposition and tau aggregation
by: Stephani A. Davis, et al.
Published: (2017-07-01)

Tau-tubulin kinase 1 phosphorylates TDP-43 at disease-relevant sites and exacerbates TDP-43 pathology
by: Yuan Tian, et al.
Published: (2021-12-01)

RNA-binding deficient TDP-43 drives cognitive decline in a mouse model of TDP-43 proteinopathy
by: Julie C Necarsulmer, et al.
Published: (2023-10-01)

Spreading of TDP-43 pathology via pyramidal tract induces ALS-like phenotypes in TDP-43 transgenic mice
by: Xuebing Ding, et al.
Published: (2021-01-01)

Metals in ALS TDP-43 Pathology
by: Lassi Koski, et al.
Published: (2021-11-01)

Mechanisms and models of TDP-43 proteinopathies
by: Petrucelli Leonard
Published: (2012-02-01)

TDP-43 Pathology in Alzheimer’s Disease
by: Axel Meneses, et al.
Published: (2021-12-01)