| Summary: | Personalized nutrition may be more effective in changing lifestyle behaviors compared to population-based guidelines. This single-arm exploratory study evaluated the impact of a 10-week personalized systems nutrition (PSN) program on lifestyle behavior and health outcomes. Healthy men and women (<i>n</i> = 82) completed the trial. Individuals were grouped into seven diet types, for which phenotypic, genotypic and behavioral data were used to generate personalized recommendations. Behavior change guidance was also provided. The intervention reduced the intake of calories (−256.2 kcal; <i>p</i> < 0.0001), carbohydrates (−22.1 g; <i>p</i> < 0.0039), sugar (−13.0 g; <i>p</i> < 0.0001), total fat (−17.3 g; <i>p</i> < 0.0001), saturated fat (−5.9 g; <i>p</i> = 0.0003) and PUFA (−2.5 g; <i>p</i> = 0.0065). Additionally, BMI (−0.6 kg/m<sup>2</sup>; <i>p</i> < 0.0001), body fat (−1.2%; <i>p</i> = 0.0192) and hip circumference (−5.8 cm; <i>p</i> < 0.0001) were decreased after the intervention. In the subgroup with the lowest phenotypic flexibility, a measure of the body’s ability to adapt to environmental stressors, LDL (−0.44 mmol/L; <i>p</i> = 0.002) and total cholesterol (−0.49 mmol/L; <i>p</i> < 0.0001) were reduced after the intervention. This study shows that a PSN program in a workforce improves lifestyle habits and reduces body weight, BMI and other health-related outcomes. Health improvement was most pronounced in the compromised phenotypic flexibility subgroup, which indicates that a PSN program may be effective in targeting behavior change in health-compromised target groups.
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