Structural basis of IRGB10 oligomerization by GTP hydrolysis

Structural basis of IRGB10 oligomerization by GTP hydrolysis

Immunity-related GTPase B10 (IRGB10) is a crucial member of the interferon (IFN)-inducible GTPases and plays a vital role in host defense mechanisms. Following infection, IRGB10 is induced by IFNs and functions by liberating pathogenic ligands to activate the inflammasome through direct disruption o...

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Bibliographic Details
Main Authors: Hyun Ji Ha, Ju Hyeong Kim, Gwan Hee Lee, Subin Kim, Hyun Ho Park
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
crystal structure
GTPase
innate immunity
IRG proteins
oligomerization
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1254415/full

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