Pan-cancer analysis of NFE2L2 mutations identifies a subset of lung cancers with distinct genomic and improved immunotherapy outcomes

Pan-cancer analysis of NFE2L2 mutations identifies a subset of lung cancers with distinct genomic and improved immunotherapy outcomes

Abstract Background Mutations in the KEAP1-NFE2L2 signaling pathway were linked to increased tumorigenesis and aggressiveness. Interestingly, not all hotspot mutations on NFE2L2 were damaging; some even were activating. However, there was conflicting evidence about the association between NFE2L2 mut...

Полное описание

Библиографические подробности
Главные авторы:	Kewei Wang, Zixi Li, Ying Xuan, Yong Zhao, Chao Deng, Meidan Wang, Chenjun Xie, Fenglai Yuan, Qingfeng Pang, Wenjun Mao, Dongyan Cai, Zhangfeng Zhong, Jie Mei
Формат:	Статья
Язык:	English
Опубликовано:	BMC 2023-10-01
Серии:	Cancer Cell International
Предметы:	NFE2L2 NSCLC Biomarker NGS Immunotherapy
Online-ссылка:	https://doi.org/10.1186/s12935-023-03056-9

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