Pan-cancer analysis of NFE2L2 mutations identifies a subset of lung cancers with distinct genomic and improved immunotherapy outcomes

Pan-cancer analysis of NFE2L2 mutations identifies a subset of lung cancers with distinct genomic and improved immunotherapy outcomes

Abstract Background Mutations in the KEAP1-NFE2L2 signaling pathway were linked to increased tumorigenesis and aggressiveness. Interestingly, not all hotspot mutations on NFE2L2 were damaging; some even were activating. However, there was conflicting evidence about the association between NFE2L2 mut...

Mô tả đầy đủ

Chi tiết về thư mục
Những tác giả chính:	Kewei Wang, Zixi Li, Ying Xuan, Yong Zhao, Chao Deng, Meidan Wang, Chenjun Xie, Fenglai Yuan, Qingfeng Pang, Wenjun Mao, Dongyan Cai, Zhangfeng Zhong, Jie Mei
Định dạng:	Bài viết
Ngôn ngữ:	English
Được phát hành:	BMC 2023-10-01
Loạt:	Cancer Cell International
Những chủ đề:	NFE2L2 NSCLC Biomarker NGS Immunotherapy
Truy cập trực tuyến:	https://doi.org/10.1186/s12935-023-03056-9

Những quyển sách tương tự

Metformin suppresses NFE2L1 pathway activation to inhibit gap junction beta protein expression in NSCLC
Bằng: Shuo Yu, et al.
Được phát hành: (2024-04-01)

Multi-Omics Analysis of Molecular Characteristics and Carcinogenic Effect of NFE2L3 in Pan-Cancer
Bằng: Mengxiao Liu, et al.
Được phát hành: (2022-06-01)

NFE2L1/Nrf1 serves as a potential therapeutical target for neurodegenerative diseases
Bằng: Kamila Łuczyńska, et al.
Được phát hành: (2024-02-01)

Cisplatin Disrupts Proteasome Bounce-Back Effect through Suppressing ZEB1/Nfe2l1 in Cholangiocarcinoma
Bằng: Yuancai Xiang, et al.
Được phát hành: (2024-03-01)

Understanding the Transcription Factor NFE2L1/NRF1 from the Perspective of Hallmarks of Cancer
Bằng: Haomeng Zhang, et al.
Được phát hành: (2024-06-01)

Unravelling the role of NFE2L1 in stress responses and related diseases
Bằng: Xingzhu Liu, et al.
Được phát hành: (2023-09-01)

NFE2L2 and SLC25A39 drive cuproptosis resistance through GSH metabolism
Bằng: Jiao Liu, et al.
Được phát hành: (2024-11-01)

Role of NFE2L1 in the Regulation of Proteostasis: Implications for Aging and Neurodegenerative Diseases
Bằng: Aswathy Chandran, et al.
Được phát hành: (2023-08-01)

Transcription Factor NFE2L1 Decreases in Glomerulonephropathies after Podocyte Damage
Bằng: Mustafa Elshani, et al.
Được phát hành: (2023-08-01)

A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer
Bằng: Chang Jiang, et al.
Được phát hành: (2022-08-01)

NFE2L3 as a Novel Biomarker Associated With IL-2/STAT5/NLRP3 Signaling Pathway in Malignant Pleural Mesothelioma and Other Cancers
Bằng: Zhen Wang, et al.
Được phát hành: (2022-05-01)

Multi-Omics Analysis of <i>NFE2L2</i>-Altered TCGA-Cervical Squamous Cell Carcinoma Patients
Bằng: Sri Vidya Ramisetti, et al.
Được phát hành: (2023-03-01)

Prevalence and Associations of Co-occurrence of <i>NFE2L2</i> Mutations and Chromosome 3q26 Amplification in Lung Cancer
Bằng: Jinfeng Liu, et al.
Được phát hành: (2024-06-01)

Gallic Acid Improves Diabetic Steatosis by Downregulating MicroRNA-34a-5p through Targeting NFE2L2 Expression in High-Fat Diet-Fed db/db Mice
Bằng: Ang-Tse Lee, et al.
Được phát hành: (2021-12-01)

Impact of Genomic Variation of NFE2L2 (rs6706649) on Serum Glyoxalase-1 Levels in A Sample of Iraqi Type 2 Diabetic Patients with Retinopathy
Bằng: Sarah Hashim Mhaibes, et al.
Được phát hành: (2025-02-01)

New insight into the CNC-bZIP member, NFE2L3, in human diseases
Bằng: Guanghui Xiong, et al.
Được phát hành: (2024-07-01)

Single-nucleus RNA-sequencing reveals NRF1/NFE2L1 as a key factor determining the thermogenesis and cellular heterogeneity and dynamics of brown adipose tissues in mice
Bằng: Wei Shen, et al.
Được phát hành: (2023-11-01)

NFE2/miR-423-5p/TFF1 axis regulates high glucose-induced apoptosis in retinal pigment epithelial cells
Bằng: Qing Xiao, et al.
Được phát hành: (2019-08-01)

Effects of Heat-Induced Oxidative Stress and Astaxanthin on the <i>NF-kB</i>, <i>NFE2L2</i> and <i>PPARα</i> Transcription Factors and Cytoprotective Capacity in the Thymus of Broilers
Bằng: Donna Lee Kuehu, et al.
Được phát hành: (2024-08-01)

Mutant Nrf2E79Q enhances the promotion and progression of a subset of oncogenic Ras keratinocytes and skin tumors
Bằng: John G. Witherspoon, et al.
Được phát hành: (2024-09-01)

Carnosine Synthase (<i>Ts</i>ATPGD) Alleviates Lipid Peroxidation Under Transcriptional Control by an <i>Nfe2</i>-like Gene in <i>Tridacna Squamosa</i>
Bằng: Zhuo Yang, et al.
Được phát hành: (2024-11-01)

Chemotherapy combined with bevacizumab for the treatment of advanced lung adenocarcinoma cancer harboring EGFR‐ANXA2, EGFR‐RAD51, ATR and BRCA2 mutations: A case report
Bằng: Rui Zhong, et al.
Được phát hành: (2020-02-01)

Retracted: SLCO4A1‐AS1 promotes cell growth and induces resistance in lung adenocarcinoma by modulating miR‐4701‐5p/NFE2L1 axis to activate WNT pathway
Bằng: Yuxuan Wei, et al.
Được phát hành: (2020-10-01)

EGFR exon 20 insertion mutations and response to osimertinib in non-small-cell lung cancer
Bằng: Wenfeng Fang, et al.
Được phát hành: (2019-06-01)

PEMBERIAN BEBERAPA DOSIS ENZIM PADA PAKAN KOMERSIAL TERHADAP KANDUNGAN SERAT KASAR, BAHAN ORGANIK DAN BETN
Bằng: Pramono Kusuma Wardani, et al.
Được phát hành: (2019-04-01)

Immunoediting of KEAP1-NRF2 mutant tumours is required to circumvent NRF2-mediated immune surveillance
Bằng: Liam Baird, et al.
Được phát hành: (2023-11-01)

mNFE: microbiome network flow entropy for detecting pre-disease states of type 1 diabetes
Bằng: Rong Gao, et al.
Được phát hành: (2024-12-01)

A NRF2-induced secretory phenotype activates immune surveillance to remove irreparably damaged cells
Bằng: Liam Baird, et al.
Được phát hành: (2023-10-01)

Identification and verification of KEAP1‐related genes and targets regulated by potential ingredients in KRAS mutant colorectal cancer
Bằng: Gang Wang, et al.
Được phát hành: (2024-09-01)

Novel insights into molecular patterns of ROS1 fusions in a large Chinese NSCLC cohort: a multicenter study
Bằng: Shengyu Zhou, et al.
Được phát hành: (2023-10-01)

Individual expression features of GPX2, NQO1 and SQSTM1 transcript variants induced by hydrogen peroxide treatment in HeLa cells
Bằng: Anna A. Belanova, et al.
Được phát hành: (2017-05-01)

Identification and therapeutic evaluation of ALK rearrangements in non‐small‐cell lung cancer
Bằng: Ruiying Zhao, et al.
Được phát hành: (2022-11-01)

Targeting Nrf2 in healthy and malignant ovarian epithelial cells: Protection versus promotion
Bằng: Monique G.P. van der Wijst, et al.
Được phát hành: (2015-08-01)

The promoting effect and mechanism of Nrf2 on cell metastasis in cervical cancer
Bằng: Mengwen Zhang, et al.
Được phát hành: (2023-07-01)

Maternal Calorie Restriction Induces a Transcriptional Cytoprotective Response in Embryonic Liver Partially Dependent on Nrf2
Bằng: George I. Habeos, et al.
Được phát hành: (2022-11-01)

Next-generation sequencing of non-small cell lung cancer at a Quebec health care cancer centre
Bằng: Mark Sorin, et al.
Được phát hành: (2023-01-01)

Clinical utility of ctDNA by amplicon based next generation sequencing in first line non small cell lung cancer patients
Bằng: Valerio Gristina, et al.
Được phát hành: (2024-09-01)

Next-generation sequencing of homologous recombination genes could predict efficacy of platinum-based chemotherapy in non-small cell lung cancer
Bằng: Linlin Zhang, et al.
Được phát hành: (2022-12-01)

Systematic regulation of immune checkpoint molecules by redox regulators CNC-bZIP transcription factors
Bằng: Haoming Ning, et al.
Được phát hành: (2024-11-01)

NSCLC Digital PCR Panel Returns Low-Input Sample Results Where Sequencing Fails
Bằng: Leah Rowland Herdt, et al.
Được phát hành: (2024-01-01)