Pan-cancer analysis of NFE2L2 mutations identifies a subset of lung cancers with distinct genomic and improved immunotherapy outcomes
Abstract Background Mutations in the KEAP1-NFE2L2 signaling pathway were linked to increased tumorigenesis and aggressiveness. Interestingly, not all hotspot mutations on NFE2L2 were damaging; some even were activating. However, there was conflicting evidence about the association between NFE2L2 mut...
| Hauptverfasser: | , , , , , , , , , , , , |
|---|---|
| Format: | Artikel |
| Sprache: | English |
| Veröffentlicht: |
BMC
2023-10-01
|
| Schriftenreihe: | Cancer Cell International |
| Schlagworte: | |
| Online Zugang: | https://doi.org/10.1186/s12935-023-03056-9 |