Experimental model of arteriovenous malformation in vitro using biological grafts
Introduction: Brain arteriovenous malformations (AVMs) represent a serious health problem all around the world. Experimental models help to better understand the pathophysiology of these lesions. Experiment: We performed an experimental model of AVM using biological grafts, arteries and veins harves...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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London Academic Publishing
2015-06-01
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| Series: | Romanian Neurosurgery |
| Subjects: | |
| Online Access: | https://www.journals.lapub.co.uk/index.php/roneurosurgery/article/view/821 |
| _version_ | 1818492156919152640 |
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| author | Aurelia Mihaela Sandu A. Giovani M. R. Gorgan |
| author_facet | Aurelia Mihaela Sandu A. Giovani M. R. Gorgan |
| author_sort | Aurelia Mihaela Sandu |
| collection | DOAJ |
| description | Introduction: Brain arteriovenous malformations (AVMs) represent a serious health problem all around the world. Experimental models help to better understand the pathophysiology of these lesions. Experiment: We performed an experimental model of AVM using biological grafts, arteries and veins harvested from chicken wings at the elbow joint. We used 14 vessels and we performed 20 end-to-end anastomoses to create a nidus with a single feeding artery and a single draining vein. The system was irrigated with colored solution. The experiment was done according with law in force regarding experimental research activity. Conclusions: Experimental models allow us to understand the hemodynamics and predict the outcome of brain AVMs in humans. This experimental model is a useful tool in understanding the hemodynamic properties of brain AVMs. It is very useful in vascular anastomosis training. |
| first_indexed | 2024-12-10T17:39:32Z |
| format | Article |
| id | doaj.art-93c740b928834ff7af14b78d38d43fb7 |
| institution | Directory Open Access Journal |
| issn | 1220-8841 2344-4959 |
| language | English |
| last_indexed | 2024-12-10T17:39:32Z |
| publishDate | 2015-06-01 |
| publisher | London Academic Publishing |
| record_format | Article |
| series | Romanian Neurosurgery |
| spelling | doaj.art-93c740b928834ff7af14b78d38d43fb72022-12-22T01:39:25ZengLondon Academic PublishingRomanian Neurosurgery1220-88412344-49592015-06-01292Experimental model of arteriovenous malformation in vitro using biological graftsAurelia Mihaela SanduA. GiovaniM. R. GorganIntroduction: Brain arteriovenous malformations (AVMs) represent a serious health problem all around the world. Experimental models help to better understand the pathophysiology of these lesions. Experiment: We performed an experimental model of AVM using biological grafts, arteries and veins harvested from chicken wings at the elbow joint. We used 14 vessels and we performed 20 end-to-end anastomoses to create a nidus with a single feeding artery and a single draining vein. The system was irrigated with colored solution. The experiment was done according with law in force regarding experimental research activity. Conclusions: Experimental models allow us to understand the hemodynamics and predict the outcome of brain AVMs in humans. This experimental model is a useful tool in understanding the hemodynamic properties of brain AVMs. It is very useful in vascular anastomosis training.https://www.journals.lapub.co.uk/index.php/roneurosurgery/article/view/821arteriovenous malformationsbiologic graftschicken wingsexperimental model |
| spellingShingle | Aurelia Mihaela Sandu A. Giovani M. R. Gorgan Experimental model of arteriovenous malformation in vitro using biological grafts Romanian Neurosurgery arteriovenous malformations biologic grafts chicken wings experimental model |
| title | Experimental model of arteriovenous malformation in vitro using biological grafts |
| title_full | Experimental model of arteriovenous malformation in vitro using biological grafts |
| title_fullStr | Experimental model of arteriovenous malformation in vitro using biological grafts |
| title_full_unstemmed | Experimental model of arteriovenous malformation in vitro using biological grafts |
| title_short | Experimental model of arteriovenous malformation in vitro using biological grafts |
| title_sort | experimental model of arteriovenous malformation in vitro using biological grafts |
| topic | arteriovenous malformations biologic grafts chicken wings experimental model |
| url | https://www.journals.lapub.co.uk/index.php/roneurosurgery/article/view/821 |
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