In silico evaluation of binding interaction and ADME study of new 1,3-diazetidin-2-one derivatives with high antiproliferative activity

In silico evaluation of binding interaction and ADME study of new 1,3-diazetidin-2-one derivatives with high antiproliferative activity

A series of eight novels' 1,3-diazetidin-2-ones have been proposed to assess their potential activities. They are intended to examine antiproliferative effects through inhibition of epidermal growth factor receptor (EGFR) expression. These eight compounds strongly interact with the EGFR protein...

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Bibliographic Details
Main Authors: Farah Haidar Abdulredha, Monther Faisal Mahdi, Ayad Kareem Khan
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2023-01-01
Series:Journal of Advanced Pharmaceutical Technology & Research
Subjects:
aza-beta-lactam
epidermal growth factor receptor
molecular docking
nonsteroidal anti-inflammatory drugs
Online Access:http://www.japtr.org/article.asp?issn=2231-4040;year=2023;volume=14;issue=3;spage=176;epage=184;aulast=Abdulredha

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