Enhancing mesenchymal stem cells cultivated on microcarriers in spinner flasks via impeller design optimization for aggregated suspensions

Enhancing mesenchymal stem cells cultivated on microcarriers in spinner flasks via impeller design optimization for aggregated suspensions

Abstract During the ex vivo expansion of umbilical cord-derived mesenchymal stem cells (hUCMSCs) in a stirred tank bioreactor, the formation of cell–microcarrier aggregates significantly affects cell proliferation and physiological activity, making it difficult to meet the quantity and quality requi...

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Bibliographic Details
Main Authors:	Botao Zhang, Qiaohui Lu, Gance Dai, Yi Zhou, Qian Ye, Yan Zhou, Wen-Song Tan
Format:	Article
Language:	English
Published:	SpringerOpen 2023-12-01
Series:	Bioresources and Bioprocessing
Subjects:	Umbilical cord-derived mesenchymal stem cells Microcarrier suspension cultivation Computational fluid dynamics Spinner flask Flow field structure Cell–microcarrier aggregate size
Online Access:	https://doi.org/10.1186/s40643-023-00707-7

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