THE REGULATORY T-LYMPHOCYTES IMMUNOSUPPRESSOR EFFECTS OF BLOOD UNDER DISSEMINATED PULMONARY TUBERCULOSIS WITH MULTI-DRUG RESISTANT M. TUBERCULOSIS
The work analyzed subpopulation structure of peripheral blood T-regulatory cells (T-reg) and production of cytokines with immunosuppressor activity (IL-10, TGF-b) in vitro in patients with disseminated pulmonary tuberculosis, depending on the sensitivity of Mycobacterium tuberculosis to anti-tubercu...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Siberian State Medical University (Tomsk)
2013-02-01
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| Series: | Бюллетень сибирской медицины |
| Subjects: | |
| Online Access: | https://bulletin.ssmu.ru/jour/article/view/61 |
| Summary: | The work analyzed subpopulation structure of peripheral blood T-regulatory cells (T-reg) and production of cytokines with immunosuppressor activity (IL-10, TGF-b) in vitro in patients with disseminated pulmonary tuberculosis, depending on the sensitivity of Mycobacterium tuberculosis to anti-tuberculosis drugs. It has been shown that Trn – natural T-regulatory lymphocytes (CD4+CD25+Foxр3+) and TGF-b cytokine, formed by them, play the leading role in the formation of immunosuppression under disseminated pulmonary tuberculosis. Besides, subpopulation imbalance of Treg-cells in patients with disseminated pulmonary tuberculosis, in case at multi-drug-resistance and drug-susceptible, is shown by the increased content of T-reg-cells with CD4+CD25+Foxр3+phenotypein combination with the deficiency of CD4+CD25+Foxр3– T-reg lymphocytes in blood. The increase in the amount of CD4+CD25+Foxр3+ T-reg-cells in blood of patients with disseminated multi-drug resistance pulmonary tuberculosis is associated with the increase in basal and BCG-induced production of TGF-bin vitro. |
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| ISSN: | 1682-0363 1819-3684 |