Host-Microbe-Pathogen Interactions: A Review of Vibrio cholerae Pathogenesis in Drosophila
Most animals maintain mutually beneficial symbiotic relationships with their intestinal microbiota. Resident microbes in the gastrointestinal tract breakdown indigestible food, provide essential nutrients, and, act as a barrier against invading microbes, such as the enteric pathogen Vibrio cholerae....
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2020-01-01
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| Series: | Frontiers in Immunology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/article/10.3389/fimmu.2019.03128/full |
| _version_ | 1798045853895622656 |
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| author | Saeideh Davoodi Edan Foley |
| author_facet | Saeideh Davoodi Edan Foley |
| author_sort | Saeideh Davoodi |
| collection | DOAJ |
| description | Most animals maintain mutually beneficial symbiotic relationships with their intestinal microbiota. Resident microbes in the gastrointestinal tract breakdown indigestible food, provide essential nutrients, and, act as a barrier against invading microbes, such as the enteric pathogen Vibrio cholerae. Over the last decades, our knowledge of V. cholerae pathogenesis, colonization, and transmission has increased tremendously. A number of animal models have been used to study how V. cholerae interacts with host-derived resources to support gastrointestinal colonization. Here, we review studies on host-microbe interactions and how infection with V. cholerae disrupts these interactions, with a focus on contributions from the Drosophila melanogaster model. We will discuss studies that highlight the connections between symbiont, host, and V. cholerae metabolism; crosstalk between V. cholerae and host microbes; and the impact of the host immune system on the lethality of V. cholerae infection. These studies suggest that V. cholerae modulates host immune-metabolic responses in the fly and improves Vibrio fitness through competition with intestinal microbes. |
| first_indexed | 2024-04-11T23:27:45Z |
| format | Article |
| id | doaj.art-93c8ea998da448b183ab6d29c0915f51 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-11T23:27:45Z |
| publishDate | 2020-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-93c8ea998da448b183ab6d29c0915f512022-12-22T03:57:15ZengFrontiers Media S.A.Frontiers in Immunology1664-32242020-01-011010.3389/fimmu.2019.03128509139Host-Microbe-Pathogen Interactions: A Review of Vibrio cholerae Pathogenesis in DrosophilaSaeideh DavoodiEdan FoleyMost animals maintain mutually beneficial symbiotic relationships with their intestinal microbiota. Resident microbes in the gastrointestinal tract breakdown indigestible food, provide essential nutrients, and, act as a barrier against invading microbes, such as the enteric pathogen Vibrio cholerae. Over the last decades, our knowledge of V. cholerae pathogenesis, colonization, and transmission has increased tremendously. A number of animal models have been used to study how V. cholerae interacts with host-derived resources to support gastrointestinal colonization. Here, we review studies on host-microbe interactions and how infection with V. cholerae disrupts these interactions, with a focus on contributions from the Drosophila melanogaster model. We will discuss studies that highlight the connections between symbiont, host, and V. cholerae metabolism; crosstalk between V. cholerae and host microbes; and the impact of the host immune system on the lethality of V. cholerae infection. These studies suggest that V. cholerae modulates host immune-metabolic responses in the fly and improves Vibrio fitness through competition with intestinal microbes.https://www.frontiersin.org/article/10.3389/fimmu.2019.03128/fullIMDDrosophila melanogasterproliferationVibrio choleraeinsulinmicrobiome |
| spellingShingle | Saeideh Davoodi Edan Foley Host-Microbe-Pathogen Interactions: A Review of Vibrio cholerae Pathogenesis in Drosophila Frontiers in Immunology IMD Drosophila melanogaster proliferation Vibrio cholerae insulin microbiome |
| title | Host-Microbe-Pathogen Interactions: A Review of Vibrio cholerae Pathogenesis in Drosophila |
| title_full | Host-Microbe-Pathogen Interactions: A Review of Vibrio cholerae Pathogenesis in Drosophila |
| title_fullStr | Host-Microbe-Pathogen Interactions: A Review of Vibrio cholerae Pathogenesis in Drosophila |
| title_full_unstemmed | Host-Microbe-Pathogen Interactions: A Review of Vibrio cholerae Pathogenesis in Drosophila |
| title_short | Host-Microbe-Pathogen Interactions: A Review of Vibrio cholerae Pathogenesis in Drosophila |
| title_sort | host microbe pathogen interactions a review of vibrio cholerae pathogenesis in drosophila |
| topic | IMD Drosophila melanogaster proliferation Vibrio cholerae insulin microbiome |
| url | https://www.frontiersin.org/article/10.3389/fimmu.2019.03128/full |
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