The effects of metformin in type 1 diabetes mellitus
Abstract Background This retrospective study investigated the effect of adding metformin to pharmacologic insulin dosing in type 1 diabetics on insulin therapy 1 year after treatment compared with patients on insulin therapy alone. Methods Twenty-nine adults with type 1 diabetes who had metformin ad...
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | BMC Endocrine Disorders |
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| Online Access: | http://link.springer.com/article/10.1186/s12902-017-0228-9 |
| _version_ | 1818063240524988416 |
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| author | Selvihan Beysel Ilknur Ozturk Unsal Muhammed Kizilgul Mustafa Caliskan Bekir Ucan Erman Cakal |
| author_facet | Selvihan Beysel Ilknur Ozturk Unsal Muhammed Kizilgul Mustafa Caliskan Bekir Ucan Erman Cakal |
| author_sort | Selvihan Beysel |
| collection | DOAJ |
| description | Abstract Background This retrospective study investigated the effect of adding metformin to pharmacologic insulin dosing in type 1 diabetics on insulin therapy 1 year after treatment compared with patients on insulin therapy alone. Methods Twenty-nine adults with type 1 diabetes who had metformin added to their insulin therapy for 12 months were compared with 29 adults with type 1 diabetes who remained on insulin-alone therapy. Results Fifty-eight patients with C peptide negative-type 1 diabetics (26 females, mean age: 29.01 ± 7.03 years, BMI: 24.18 ± 3.16 kg/m2) were analyzed. Age, sex, body weight, insulin dose requirement, plasma glucose (PG), blood pressure (BP), and lipids did not differ between groups before treatment (p > 0.05). Metabolic syndrome (44.8 vs 41.4%, p > 0.05) did not differ between the metformin-insulin and insulin alone groups before treatment. Metabolic syndrome was more decreased in the metformin-insulin group than in the insulin alone group after treatment (−8.9 ± 1.3 vs. 2.5 ± 0.6%, p = 0.028). Insulin dose requirement was lower in the metformin-insulin group than in the insulin alone group (−0.03 vs. 0.11 IU/kg/d, p = 0.006). Fasting PG (−26.9 ± 54.2 vs. 0.7 ± 29.5 mg/dL, p = 0.022) and postprandial PG (−43.1 ± 61.8 mg/dL vs. −3.1 ± 40.1 mg/dL, p = 0.010) was more decreased in the metformin-insulin group than in the insulin alone group. Body weight, lipids, and HbA1c did not differ between the groups (p > 0.05). Conclusions Metformin decreased glucose concentrations, reduced metabolic syndrome, as well as insulin dose requirement more than insulin therapy alone, 1 year after treatment. These results were independent of blood lipid improvement or weight loss, although on average weight remained decreased with metformin-insulin therapy, whereas the average weight increased with insulin therapy alone. |
| first_indexed | 2024-12-10T14:16:58Z |
| format | Article |
| id | doaj.art-93c9868c62c44d74bdf425b9e3599ec4 |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-12-10T14:16:58Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-93c9868c62c44d74bdf425b9e3599ec42022-12-22T01:45:19ZengBMCBMC Endocrine Disorders1472-68232018-01-011811610.1186/s12902-017-0228-9The effects of metformin in type 1 diabetes mellitusSelvihan Beysel0Ilknur Ozturk Unsal1Muhammed Kizilgul2Mustafa Caliskan3Bekir Ucan4Erman Cakal5Department of Endocrinology and Metabolism, Eskisehir State HospitalDepartment of Endocrinology and Metabolism, Ankara Diskapi Teaching and Research HospitalDepartment of Endocrinology and Metabolism, Kilis State HospitalDepartment of Endocrinology and Metabolism, Duzce Ataturk State HospitalDepartment of Endocrinology and Metabolism, Ankara Diskapi Teaching and Research HospitalDepartment of Endocrinology and Metabolism, Ankara Diskapi Teaching and Research HospitalAbstract Background This retrospective study investigated the effect of adding metformin to pharmacologic insulin dosing in type 1 diabetics on insulin therapy 1 year after treatment compared with patients on insulin therapy alone. Methods Twenty-nine adults with type 1 diabetes who had metformin added to their insulin therapy for 12 months were compared with 29 adults with type 1 diabetes who remained on insulin-alone therapy. Results Fifty-eight patients with C peptide negative-type 1 diabetics (26 females, mean age: 29.01 ± 7.03 years, BMI: 24.18 ± 3.16 kg/m2) were analyzed. Age, sex, body weight, insulin dose requirement, plasma glucose (PG), blood pressure (BP), and lipids did not differ between groups before treatment (p > 0.05). Metabolic syndrome (44.8 vs 41.4%, p > 0.05) did not differ between the metformin-insulin and insulin alone groups before treatment. Metabolic syndrome was more decreased in the metformin-insulin group than in the insulin alone group after treatment (−8.9 ± 1.3 vs. 2.5 ± 0.6%, p = 0.028). Insulin dose requirement was lower in the metformin-insulin group than in the insulin alone group (−0.03 vs. 0.11 IU/kg/d, p = 0.006). Fasting PG (−26.9 ± 54.2 vs. 0.7 ± 29.5 mg/dL, p = 0.022) and postprandial PG (−43.1 ± 61.8 mg/dL vs. −3.1 ± 40.1 mg/dL, p = 0.010) was more decreased in the metformin-insulin group than in the insulin alone group. Body weight, lipids, and HbA1c did not differ between the groups (p > 0.05). Conclusions Metformin decreased glucose concentrations, reduced metabolic syndrome, as well as insulin dose requirement more than insulin therapy alone, 1 year after treatment. These results were independent of blood lipid improvement or weight loss, although on average weight remained decreased with metformin-insulin therapy, whereas the average weight increased with insulin therapy alone.http://link.springer.com/article/10.1186/s12902-017-0228-9MetforminType 1 diabetesInsulin requirement |
| spellingShingle | Selvihan Beysel Ilknur Ozturk Unsal Muhammed Kizilgul Mustafa Caliskan Bekir Ucan Erman Cakal The effects of metformin in type 1 diabetes mellitus BMC Endocrine Disorders Metformin Type 1 diabetes Insulin requirement |
| title | The effects of metformin in type 1 diabetes mellitus |
| title_full | The effects of metformin in type 1 diabetes mellitus |
| title_fullStr | The effects of metformin in type 1 diabetes mellitus |
| title_full_unstemmed | The effects of metformin in type 1 diabetes mellitus |
| title_short | The effects of metformin in type 1 diabetes mellitus |
| title_sort | effects of metformin in type 1 diabetes mellitus |
| topic | Metformin Type 1 diabetes Insulin requirement |
| url | http://link.springer.com/article/10.1186/s12902-017-0228-9 |
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