Lung function is related to salivary cytokines and hormones in healthy children. An exploratory cross‐sectional study
Abstract Pulmonary mechanics has been traditionally viewed as determined by lung size and physical factors such as frictional forces and tissue viscoelastic properties, but few information exists regarding potential influences of cytokines and hormones on lung function. Concentrations of 28 cytokine...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | Physiological Reports |
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| Online Access: | https://doi.org/10.14814/phy2.15861 |
| _version_ | 1797389353796763648 |
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| author | Laura Gochicoa‐Rangel Jaime Chávez Rodrigo Del‐Río‐Hidalgo Selene Guerrero‐Zúñiga Uri Mora‐Romero Rosaura Benítez‐Pérez Luis Rodríguez‐Moreno Luis Torre‐Bouscoulet Mario H. Vargas |
| author_facet | Laura Gochicoa‐Rangel Jaime Chávez Rodrigo Del‐Río‐Hidalgo Selene Guerrero‐Zúñiga Uri Mora‐Romero Rosaura Benítez‐Pérez Luis Rodríguez‐Moreno Luis Torre‐Bouscoulet Mario H. Vargas |
| author_sort | Laura Gochicoa‐Rangel |
| collection | DOAJ |
| description | Abstract Pulmonary mechanics has been traditionally viewed as determined by lung size and physical factors such as frictional forces and tissue viscoelastic properties, but few information exists regarding potential influences of cytokines and hormones on lung function. Concentrations of 28 cytokines and hormones were measured in saliva from clinically healthy scholar children, purposely selected to include a wide range of body mass index (BMI). Lung function was assessed by impulse oscillometry, spirometry, and diffusing capacity for carbon monoxide, and expressed as z‐score or percent predicted. Ninety‐six scholar children (55.2% female) were enrolled. Bivariate analysis showed that almost all lung function variables correlated with one or more cytokine or hormone, mainly in boys, but only some of them remained statistically significant in the multiple regression analyses. Thus, after adjusting by height, age, and BMI, salivary concentrations of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) in boys were associated with zR5‐R20 and reactance parameters (zX20, zFres, and zAX), while glucagon inversely correlated with resistances (zR5 and zR20). Thus, in physiological conditions, part of the mechanics of breathing might be influenced by some cytokines and hormones, including glucagon and GM‐CSF. This endogenous influence is a novel concept that warrants in‐depth characterization. |
| first_indexed | 2024-03-08T22:54:38Z |
| format | Article |
| id | doaj.art-93c9d1de24e445bd978a74fd8a0f9a63 |
| institution | Directory Open Access Journal |
| issn | 2051-817X |
| language | English |
| last_indexed | 2024-03-08T22:54:38Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | Physiological Reports |
| spelling | doaj.art-93c9d1de24e445bd978a74fd8a0f9a632023-12-16T06:30:47ZengWileyPhysiological Reports2051-817X2023-12-011123n/an/a10.14814/phy2.15861Lung function is related to salivary cytokines and hormones in healthy children. An exploratory cross‐sectional studyLaura Gochicoa‐Rangel0Jaime Chávez1Rodrigo Del‐Río‐Hidalgo2Selene Guerrero‐Zúñiga3Uri Mora‐Romero4Rosaura Benítez‐Pérez5Luis Rodríguez‐Moreno6Luis Torre‐Bouscoulet7Mario H. Vargas8Departamento de Fisiología Respiratoria Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas Mexico City MexicoDepartamento de Investigación en Hiperreactividad Bronquial Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas Mexico City MexicoDepartamento de Fisiología Respiratoria Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas Mexico City MexicoDepartamento de Fisiología Respiratoria Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas Mexico City MexicoDepartamento de Fisiología Respiratoria Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas Mexico City MexicoDepartamento de Fisiología Respiratoria Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas Mexico City MexicoInstituto de Desarrollo e Innovación en Fisiología Respiratoria Mexico City MexicoInstituto de Desarrollo e Innovación en Fisiología Respiratoria Mexico City MexicoDepartamento de Investigación en Hiperreactividad Bronquial Instituto Nacional de Enfermedades Respiratorias Ismael Cosío Villegas Mexico City MexicoAbstract Pulmonary mechanics has been traditionally viewed as determined by lung size and physical factors such as frictional forces and tissue viscoelastic properties, but few information exists regarding potential influences of cytokines and hormones on lung function. Concentrations of 28 cytokines and hormones were measured in saliva from clinically healthy scholar children, purposely selected to include a wide range of body mass index (BMI). Lung function was assessed by impulse oscillometry, spirometry, and diffusing capacity for carbon monoxide, and expressed as z‐score or percent predicted. Ninety‐six scholar children (55.2% female) were enrolled. Bivariate analysis showed that almost all lung function variables correlated with one or more cytokine or hormone, mainly in boys, but only some of them remained statistically significant in the multiple regression analyses. Thus, after adjusting by height, age, and BMI, salivary concentrations of granulocyte‐macrophage colony‐stimulating factor (GM‐CSF) in boys were associated with zR5‐R20 and reactance parameters (zX20, zFres, and zAX), while glucagon inversely correlated with resistances (zR5 and zR20). Thus, in physiological conditions, part of the mechanics of breathing might be influenced by some cytokines and hormones, including glucagon and GM‐CSF. This endogenous influence is a novel concept that warrants in‐depth characterization.https://doi.org/10.14814/phy2.15861diffusing capacity for carbon monoxideglucagonGM‐CSFgranulocyte‐macrophage colony‐stimulating factorlung functionoscillometry |
| spellingShingle | Laura Gochicoa‐Rangel Jaime Chávez Rodrigo Del‐Río‐Hidalgo Selene Guerrero‐Zúñiga Uri Mora‐Romero Rosaura Benítez‐Pérez Luis Rodríguez‐Moreno Luis Torre‐Bouscoulet Mario H. Vargas Lung function is related to salivary cytokines and hormones in healthy children. An exploratory cross‐sectional study Physiological Reports diffusing capacity for carbon monoxide glucagon GM‐CSF granulocyte‐macrophage colony‐stimulating factor lung function oscillometry |
| title | Lung function is related to salivary cytokines and hormones in healthy children. An exploratory cross‐sectional study |
| title_full | Lung function is related to salivary cytokines and hormones in healthy children. An exploratory cross‐sectional study |
| title_fullStr | Lung function is related to salivary cytokines and hormones in healthy children. An exploratory cross‐sectional study |
| title_full_unstemmed | Lung function is related to salivary cytokines and hormones in healthy children. An exploratory cross‐sectional study |
| title_short | Lung function is related to salivary cytokines and hormones in healthy children. An exploratory cross‐sectional study |
| title_sort | lung function is related to salivary cytokines and hormones in healthy children an exploratory cross sectional study |
| topic | diffusing capacity for carbon monoxide glucagon GM‐CSF granulocyte‐macrophage colony‐stimulating factor lung function oscillometry |
| url | https://doi.org/10.14814/phy2.15861 |
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