Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects
Dongseong Shin,1,2 Young Sil Eom, 3,4 Suk Chon,5 Byung-Joon Kim, 3,4 Kyung-Sang Yu,6,* Dae Ho Lee 3,4,*1Department of Pharmacology, Gachon University College of Medicine, Incheon, Korea; 2Clinical Trials Center, Gachon University Gil Medical Center, Incheon, Korea; 3Department of Internal Medicine,...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2019-04-01
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| Series: | Diabetes, Metabolic Syndrome and Obesity |
| Subjects: | |
| Online Access: | https://www.dovepress.com/factors-influencing-insulin-sensitivity-during-hyperinsulinemic-euglyc-peer-reviewed-article-DMSO |
| _version_ | 1797935473994235904 |
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| author | Shin D Eom YS Chon S Kim BJ Yu KS Lee DH |
| author_facet | Shin D Eom YS Chon S Kim BJ Yu KS Lee DH |
| author_sort | Shin D |
| collection | DOAJ |
| description | Dongseong Shin,1,2 Young Sil Eom, 3,4 Suk Chon,5 Byung-Joon Kim, 3,4 Kyung-Sang Yu,6,* Dae Ho Lee 3,4,*1Department of Pharmacology, Gachon University College of Medicine, Incheon, Korea; 2Clinical Trials Center, Gachon University Gil Medical Center, Incheon, Korea; 3Department of Internal Medicine, Gachon University College of Medicine, Incheon, Korea; 4Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea; 5Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea; 6Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea*These authors contributed equally to this workBackground and objective: The effects of age and related factors on insulin sensitivity have not been definitively evaluated in East Asian populations. We proposed a reference range for the glucose disposal rate (M-value) on hyperinsulinemic-euglycemic study and its association with other parameters.Methods: Healthy, non-diabetic young (n=10) and elderly (n=13) male subjects with normal body mass index were eligible for this study. Subjects who passed the oral glucose tolerance test (OGTT) underwent hyperinsulinemic-euglycemic clamp with high-dose (80 mU/m2·min) insulin infusion.Results: M-values were normalized to body weight (MBW) and fat-free mass (MFFM). Neither M-value was significantly different between age groups (P=0.458 and P=0.900, respectively). An inverse correlation was observed between MFFM and baseline insulin (r=−0.418; P=0.047), baseline C-peptide (r=−0.426; P=0.043) and OGTT 2-hour glucose (r=−0.452; P=0.030). Regarding correlations with other insulin sensitivity indices, M-values were positively associated with the Matsuda index but not with homeostasis model assessment of insulin resistance.Conclusion: Our results suggest that age is not a critical determinant of insulin sensitivity, while fasting insulin and C-peptide levels, OGTT 2-hour glucose level, and Matsuda index are predictable markers of insulin sensitivity in healthy Koreans.Keywords: insulin sensitivity, hyperinsulinemic-euglycemic clamp, glucose disposal rate, age, Matsuda index |
| first_indexed | 2024-04-10T18:14:55Z |
| format | Article |
| id | doaj.art-93ca5afbe4df40b292f3e736dc5c2192 |
| institution | Directory Open Access Journal |
| issn | 1178-7007 |
| language | English |
| last_indexed | 2024-04-10T18:14:55Z |
| publishDate | 2019-04-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Diabetes, Metabolic Syndrome and Obesity |
| spelling | doaj.art-93ca5afbe4df40b292f3e736dc5c21922023-02-02T09:06:43ZengDove Medical PressDiabetes, Metabolic Syndrome and Obesity1178-70072019-04-01Volume 1246947645010Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjectsShin DEom YSChon SKim BJYu KSLee DHDongseong Shin,1,2 Young Sil Eom, 3,4 Suk Chon,5 Byung-Joon Kim, 3,4 Kyung-Sang Yu,6,* Dae Ho Lee 3,4,*1Department of Pharmacology, Gachon University College of Medicine, Incheon, Korea; 2Clinical Trials Center, Gachon University Gil Medical Center, Incheon, Korea; 3Department of Internal Medicine, Gachon University College of Medicine, Incheon, Korea; 4Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea; 5Department of Endocrinology and Metabolism, Kyung Hee University School of Medicine, Seoul, Korea; 6Department of Clinical Pharmacology and Therapeutics, Seoul National University College of Medicine and Hospital, Seoul, Korea*These authors contributed equally to this workBackground and objective: The effects of age and related factors on insulin sensitivity have not been definitively evaluated in East Asian populations. We proposed a reference range for the glucose disposal rate (M-value) on hyperinsulinemic-euglycemic study and its association with other parameters.Methods: Healthy, non-diabetic young (n=10) and elderly (n=13) male subjects with normal body mass index were eligible for this study. Subjects who passed the oral glucose tolerance test (OGTT) underwent hyperinsulinemic-euglycemic clamp with high-dose (80 mU/m2·min) insulin infusion.Results: M-values were normalized to body weight (MBW) and fat-free mass (MFFM). Neither M-value was significantly different between age groups (P=0.458 and P=0.900, respectively). An inverse correlation was observed between MFFM and baseline insulin (r=−0.418; P=0.047), baseline C-peptide (r=−0.426; P=0.043) and OGTT 2-hour glucose (r=−0.452; P=0.030). Regarding correlations with other insulin sensitivity indices, M-values were positively associated with the Matsuda index but not with homeostasis model assessment of insulin resistance.Conclusion: Our results suggest that age is not a critical determinant of insulin sensitivity, while fasting insulin and C-peptide levels, OGTT 2-hour glucose level, and Matsuda index are predictable markers of insulin sensitivity in healthy Koreans.Keywords: insulin sensitivity, hyperinsulinemic-euglycemic clamp, glucose disposal rate, age, Matsuda indexhttps://www.dovepress.com/factors-influencing-insulin-sensitivity-during-hyperinsulinemic-euglyc-peer-reviewed-article-DMSOinsulin sensitivityhyperinsulinemic-euglycemic clampglucose disposal rateageMatsuda index |
| spellingShingle | Shin D Eom YS Chon S Kim BJ Yu KS Lee DH Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects Diabetes, Metabolic Syndrome and Obesity insulin sensitivity hyperinsulinemic-euglycemic clamp glucose disposal rate age Matsuda index |
| title | Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects |
| title_full | Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects |
| title_fullStr | Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects |
| title_full_unstemmed | Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects |
| title_short | Factors influencing insulin sensitivity during hyperinsulinemic-euglycemic clamp in healthy Korean male subjects |
| title_sort | factors influencing insulin sensitivity during hyperinsulinemic euglycemic clamp in healthy korean male subjects |
| topic | insulin sensitivity hyperinsulinemic-euglycemic clamp glucose disposal rate age Matsuda index |
| url | https://www.dovepress.com/factors-influencing-insulin-sensitivity-during-hyperinsulinemic-euglyc-peer-reviewed-article-DMSO |
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