Mutual Influence of Human Cytochrome P450 Enzymes and UDP-Glucuronosyltransferases on Their Respective Activities in Recombinant Fission Yeast

Mutual Influence of Human Cytochrome P450 Enzymes and UDP-Glucuronosyltransferases on Their Respective Activities in Recombinant Fission Yeast

Cytochromes P450 (CYPs) and UDP-glucuronosyltransferases (UGTs) are the most important human drug metabolizing enzymes, but their mutual interactions are poorly understood. In this study, we recombinantly co-expressed of each one of the 19 human members of the UGT families 1 and 2 with either CYP2C9...

Szczegółowa specyfikacja

Opis bibliograficzny
Główni autorzy:	Sangeeta Shrestha Sharma, Shishir Sharma, Jie Zhao, Matthias Bureik
Format:	Artykuł
Język:	English
Wydane:	MDPI AG 2023-01-01
Seria:	Biomedicines
Hasła przedmiotowe:	Cytochrome P450 UDP-glucuronosyltransferase CYP2C9 CYP2D6 CYP4Z1 UGT2B7
Dostęp online:	https://www.mdpi.com/2227-9059/11/2/281

Podobne zapisy

Identification of Bromophenols' glucuronidation and its induction on UDP- glucuronosyltransferases isoforms
od: Haoqian Zhang, i wsp.
Wydane: (2024-05-01)

Cytochrome P450 genes expression in human prostate cancer
od: Oksana Maksymchuk, i wsp.
Wydane: (2024-03-01)

Effects of short-chain per- and polyfluoroalkyl substances (PFAS) on human cytochrome P450 (CYP450) enzymes and human hepatocytes: An in vitro study
od: Megan E. Solan, i wsp.
Wydane: (2023-01-01)

Mutual Modulation of the Activities of Human CYP2D6 and Four UGTs during the Metabolism of Propranolol
od: Fan Yang, i wsp.
Wydane: (2023-08-01)

Intratumoural Cytochrome P450 Expression in Breast Cancer: Impact on Standard of Care Treatment and New Efforts to Develop Tumour-Selective Therapies
od: Smarakan Sneha, i wsp.
Wydane: (2021-03-01)

DEVELOPMENT AND VALIDATION OF SIMULTANEOUS ASSAY OF SUBSTRATES-MARKERS OF MAIN CYTOCHROME P450 ISOFORMS AND THEIR METABOLITES USING HPLC-MS/MS
od: E. A. Egorenkov, i wsp.
Wydane: (2019-01-01)

Molecular Dynamics Simulations of a Cytochrome P450 from <i>Tepidiphilus thermophilus</i> (P450-TT) Reveal How Its Substrate-Binding Channel Opens
od: Abayomi S. Faponle, i wsp.
Wydane: (2021-06-01)

SNPs in cytochromes P450 catalyzing cholesterol degradation in brain are associated with Parkinson’s disease
od: Polina Petkova-Kirova, i wsp.
Wydane: (2024-09-01)

Inhibitory effects of herbal medicines with claimed anticancer indications on cytochrome P450—An evaluation of drug-herb interactions risk
od: Misheck Mudyiwa, i wsp.
Wydane: (2023-09-01)

Electrochemical Activity of Cytochrome P450 1A2: The Relevance of O2 Control and the Natural Electron Donor
od: Dr. Célia M. Silveira, i wsp.
Wydane: (2021-02-01)

In Vitro Interaction of AB-FUBINACA with Human Cytochrome P450, UDP-Glucuronosyltransferase Enzymes and Drug Transporters
od: Sunjoo Kim, i wsp.
Wydane: (2020-10-01)

FREQUENCIES OF POLYMORPHISMS IN THE CYTOCHROME’S P450 GENES OF WARFARIN TRANSFORMATION IN A EUROPEAN POPULATION OF EASTERN SIBERIA
od: T. A. Bairova, i wsp.
Wydane: (2018-09-01)

Impact of Pomegranate Juice on the Pharmacokinetics of CYP3A4- and CYP2C9-Mediated Drugs Metabolism: A Preclinical and Clinical Review
od: Kenza Mansoor, i wsp.
Wydane: (2023-02-01)

Global transcriptome modulation by xenobiotics: the role of alternative splicing in adaptive responses to chemical exposures
od: Andrew J. Annalora, i wsp.
Wydane: (2024-11-01)

Cytochrome P450 2J2*7 Single-nucleotide Polymorphism and Nocturnal Hypertension in an Elderly Turkish Population
od: Elif Hilal Vural, i wsp.
Wydane: (2024-07-01)

Association of CYP2C9*2 Allele with Sulphonylurea-Induced Hypoglycaemia in Type 2 Diabetes Mellitus Patients: A Pharmacogenetic Study in Pakistani Pashtun Population
od: Asif Jan, i wsp.
Wydane: (2023-08-01)

Cytochrome P450 F3 promotes colorectal cancer via inhibiting NRF2-mediated ferroptosis
od: Ziyang Xu, i wsp.
Wydane: (2024-10-01)

Placental cytochrome P450 methylomes in infants exposed to prenatal opioids: exploring the effects of neonatal opioid withdrawal syndrome on health horizons
od: Uppala Radhakrishna, i wsp.
Wydane: (2024-01-01)

Quantitative analysis of the UDP‐glucuronosyltransferase transcriptome in human tissues
od: Lucas Zhou, i wsp.
Wydane: (2023-12-01)

Descriptors of Cytochrome Inhibitors and Useful Machine Learning Based Methods for the Design of Safer Drugs
od: Tyler C. Beck, i wsp.
Wydane: (2021-05-01)

Sensing the Generation of Intracellular Free Electrons Using the Inactive Catalytic Subunit of Cytochrome P450s as a Sink
od: Damilare D. Akintade, i wsp.
Wydane: (2020-07-01)

UDP-glucuronosyltransferase is involved in susceptibility of Chironomus kiiensis Tokunaga, 1936 (Diptera: Chironomidae) to insecticides
od: Chengcheng Fan, i wsp.
Wydane: (2023-09-01)

Mechanism of hepatoprotective action of methionine and composition “Metovitan” against a background of antituberculosis drugs administration to rats
od: S. I. Anisimova, i wsp.
Wydane: (2013-04-01)

A Computational Inter-Species Study on Safrole Phase I Metabolism-Dependent Bioactivation: A Mechanistic Insight into the Study of Possible Differences among Species
od: Lorenzo Pedroni, i wsp.
Wydane: (2023-01-01)

Aspects of «Cocktail» cytochrome P450 activity determination methods application with the view of drug treatment rationalization
od: E. . Egorenkov, i wsp.
Wydane: (2020-04-01)

Effect of eugenol on cytochrome P450 1A2, 2C9, 2D6, and 3A4 activity in human liver microsomes
od: Naif Fahad M. Alharbi, i wsp.
Wydane: (2024-07-01)

Impact of Cytochrome P450 Enzymes on the Phase I Metabolism of Drugs
od: Domenico Iacopetta, i wsp.
Wydane: (2023-05-01)

The Atypical Antipsychotic Lurasidone Affects Brain but Not Liver Cytochrome P450 2D (CYP2D) Activity. A Comparison with Other Novel Neuroleptics and Significance for Drug Treatment of Schizophrenia
od: Przemysław J. Danek, i wsp.
Wydane: (2022-11-01)

«COCKTAIL» METHODS OF CYTOCHROME P450 ISOFORMS ACTIVITY DETERMINATION <i>IN VIVO</i> USING BIOANALYTICAL METHODS: ACTUAL METHODS REVIEW AND OPPORTUNITIES OF THEIR APPLICATION IN CLINICAL PRACTICE
od: E. A. Egorenkov, i wsp.
Wydane: (2019-01-01)

Genetic variations in the drug metabolizing enzyme, CYP2E1, among various ethnic populations of Pakistan
od: Sagheer Ahmed, i wsp.
Wydane: (2020-08-01)

Detoxification Cytochrome P450s (CYPs) in Families 1–3 Produce Functional Oxylipins from Polyunsaturated Fatty Acids
od: Jazmine A. Eccles, i wsp.
Wydane: (2022-12-01)

Metabolism of 2,3-Dehydrosilybin A and 2,3-Dehydrosilybin B: A Study with Human Hepatocytes and Recombinant UDP-Glucuronosyltransferases and Sulfotransferases
od: Jiří Vrba, i wsp.
Wydane: (2021-06-01)

Stable Chinese Hamster Ovary Suspension Cell Lines Harboring Recombinant Human Cytochrome P450 Oxidoreductase and Human Cytochrome P450 Monooxygenases as Platform for In Vitro Biotransformation Studies
od: Christian Schulz, i wsp.
Wydane: (2023-08-01)

Interactions of Mycotoxin Alternariol with Cytochrome P450 Enzymes and OATP Transporters
od: Eszter Fliszár-Nyúl, i wsp.
Wydane: (2022-12-01)

Water Exchange from the Buried Binding Sites of Cytochrome P450 Enzymes 1A2, 2D6, and 3A4 Correlates with Conformational Fluctuations
od: Olgun Guvench
Wydane: (2024-01-01)

Functional characterization of the chlorzoxazone 6-hydroxylation activity of human cytochrome P450 2E1 allelic variants in Han Chinese
od: Ting Wang, i wsp.
Wydane: (2020-07-01)

Expression of UDP Glucuronosyltransferases 2B15 and 2B17 is associated with methylation status in prostate cancer cells
od: Farideh Shafiee-Kermani, i wsp.
Wydane: (2021-03-01)

Efficacy and safety of antipsychotics in adolescents with an acute psychotic episode in relation to the activity of CYP3A and CYP2D6 isoenzymes
od: D. V. Ivashchenko, i wsp.
Wydane: (2020-12-01)

An extract from the frass of swallowtail butterfly (Papilio machaon) larvae inhibits HCT116 colon cancer cell proliferation but not other cancer cell types
od: Miho Nakano, i wsp.
Wydane: (2023-12-01)

The Development and Validation of a Novel “Dual Cocktail” Probe for Cytochrome P450s and Transporter Functions to Evaluate Pharmacokinetic Drug-Drug and Herb-Drug Interactions
od: Mihwa Kwon, i wsp.
Wydane: (2020-09-01)