Senescence during early differentiation reduced the chondrogenic differentiation capacity of mesenchymal progenitor cells

Senescence during early differentiation reduced the chondrogenic differentiation capacity of mesenchymal progenitor cells

Introduction: Mesenchymal stromal/progenitor cells (MSCs) are promising for cartilage cell-based therapies due to their chondrogenic differentiation capacity. However, MSCs can become senescent during in vitro expansion, a state characterized by stable cell cycle arrest, metabolic alterations, and s...

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Bibliographic Details
Main Authors: Chantal Voskamp, Wendy J. L. M. Koevoet, Gerjo J. V. M. Van Osch, Roberto Narcisi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
senescence
cartilage
MSC
chondrogenesis
SASP
regenerative medicine
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2023.1241338/full

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