Irradiation induces DJ-1 secretion from esophageal squamous cell carcinoma cells to accelerate metastasis of bystander cells via a TGF-β1 positive feedback loop

Irradiation induces DJ-1 secretion from esophageal squamous cell carcinoma cells to accelerate metastasis of bystander cells via a TGF-β1 positive feedback loop

Abstract Background Radiation-induced bystander effect (RIBE) can promote tumor metastasis contributing to the failure of radiotherapy for esophageal squamous cell carcinoma (ESCC). Aberrant expression of DJ-1 has been identified in ESCC; however, the relationship between DJ-1 and RIBE in ESCC remai...

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Bibliographic Details
Main Authors: Junjie Gu, Yuanyuan Sun, Jiahang Song, Ruiling Zhao, Xiaoke Di, Yumeng Zhang, Xiaolin Ge, Shu Zhang, Yun Gu, Xinchen Sun
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Journal of Experimental & Clinical Cancer Research
Subjects:
DJ-1
TGF-β1
HSC70
Smad3
TSP1
Esophageal squamous cell carcinoma
Online Access:https://doi.org/10.1186/s13046-022-02471-6

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