PLATO: A Predictive Drug Discovery Web Platform for Efficient Target Fishing and Bioactivity Profiling of Small Molecules
PLATO (Polypharmacology pLATform predictiOn) is an easy-to-use drug discovery web platform, which has been designed with a two-fold objective: to fish putative protein drug targets and to compute bioactivity values of small molecules. Predictions are based on the similarity principle, through a reve...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-05-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/23/9/5245 |
| _version_ | 1797504355699523584 |
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| author | Fulvio Ciriaco Nicola Gambacorta Daniela Trisciuzzi Orazio Nicolotti |
| author_facet | Fulvio Ciriaco Nicola Gambacorta Daniela Trisciuzzi Orazio Nicolotti |
| author_sort | Fulvio Ciriaco |
| collection | DOAJ |
| description | PLATO (Polypharmacology pLATform predictiOn) is an easy-to-use drug discovery web platform, which has been designed with a two-fold objective: to fish putative protein drug targets and to compute bioactivity values of small molecules. Predictions are based on the similarity principle, through a reverse ligand-based screening, based on a collection of 632,119 compounds known to be experimentally active on 6004 protein targets. An efficient backend implementation allows to speed-up the process that returns results for query in less than 20 s. The graphical user interface is intuitive to give practitioners easy input and transparent output, which is available as a standard report in portable document format. PLATO has been validated on thousands of external data, with performances better than those of other parallel approaches. PLATO is available free of charge (http://plato.uniba.it/ accessed on 13 April 2022). |
| first_indexed | 2024-03-10T04:03:28Z |
| format | Article |
| id | doaj.art-93cf4e9faafc43929b7066f653d233cc |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-10T04:03:28Z |
| publishDate | 2022-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-93cf4e9faafc43929b7066f653d233cc2023-11-23T08:29:13ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-05-01239524510.3390/ijms23095245PLATO: A Predictive Drug Discovery Web Platform for Efficient Target Fishing and Bioactivity Profiling of Small MoleculesFulvio Ciriaco0Nicola Gambacorta1Daniela Trisciuzzi2Orazio Nicolotti3Dipartimento di Chimica, Università degli Studi di Bari “Aldo Moro”, Via E. Orabona, 4, I-70125 Bari, ItalyDipartimento di Farmacia Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro”, Via E. Orabona, 4, I-70125 Bari, ItalyDipartimento di Farmacia Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro”, Via E. Orabona, 4, I-70125 Bari, ItalyDipartimento di Farmacia Scienze del Farmaco, Università degli Studi di Bari “Aldo Moro”, Via E. Orabona, 4, I-70125 Bari, ItalyPLATO (Polypharmacology pLATform predictiOn) is an easy-to-use drug discovery web platform, which has been designed with a two-fold objective: to fish putative protein drug targets and to compute bioactivity values of small molecules. Predictions are based on the similarity principle, through a reverse ligand-based screening, based on a collection of 632,119 compounds known to be experimentally active on 6004 protein targets. An efficient backend implementation allows to speed-up the process that returns results for query in less than 20 s. The graphical user interface is intuitive to give practitioners easy input and transparent output, which is available as a standard report in portable document format. PLATO has been validated on thousands of external data, with performances better than those of other parallel approaches. PLATO is available free of charge (http://plato.uniba.it/ accessed on 13 April 2022).https://www.mdpi.com/1422-0067/23/9/5245target fishingbioactivity profilingmultifingerprint similarity searchingdrug repurposing |
| spellingShingle | Fulvio Ciriaco Nicola Gambacorta Daniela Trisciuzzi Orazio Nicolotti PLATO: A Predictive Drug Discovery Web Platform for Efficient Target Fishing and Bioactivity Profiling of Small Molecules International Journal of Molecular Sciences target fishing bioactivity profiling multifingerprint similarity searching drug repurposing |
| title | PLATO: A Predictive Drug Discovery Web Platform for Efficient Target Fishing and Bioactivity Profiling of Small Molecules |
| title_full | PLATO: A Predictive Drug Discovery Web Platform for Efficient Target Fishing and Bioactivity Profiling of Small Molecules |
| title_fullStr | PLATO: A Predictive Drug Discovery Web Platform for Efficient Target Fishing and Bioactivity Profiling of Small Molecules |
| title_full_unstemmed | PLATO: A Predictive Drug Discovery Web Platform for Efficient Target Fishing and Bioactivity Profiling of Small Molecules |
| title_short | PLATO: A Predictive Drug Discovery Web Platform for Efficient Target Fishing and Bioactivity Profiling of Small Molecules |
| title_sort | plato a predictive drug discovery web platform for efficient target fishing and bioactivity profiling of small molecules |
| topic | target fishing bioactivity profiling multifingerprint similarity searching drug repurposing |
| url | https://www.mdpi.com/1422-0067/23/9/5245 |
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