Effects of active vitamin D analogues on muscle strength and falls in elderly people: an updated meta-analysis
BackgroundElderly people are at high risk of falls due to decreased muscle strength. So far, there is currently no officially approved medication for treating muscle strength loss. The active vitamin D analogues are promising but inconsistent results have been reported in previous studies. The prese...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-02-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2024.1327623/full |
| _version_ | 1827367445731475456 |
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| author | An Xiong Haibo Li Miaoying Lin Feng Xu Xuedi Xia Dexing Dai Ruoman Sun Yali Ling Lei Qiu Rui Wang Ya Ding Zhongjian Xie |
| author_facet | An Xiong Haibo Li Miaoying Lin Feng Xu Xuedi Xia Dexing Dai Ruoman Sun Yali Ling Lei Qiu Rui Wang Ya Ding Zhongjian Xie |
| author_sort | An Xiong |
| collection | DOAJ |
| description | BackgroundElderly people are at high risk of falls due to decreased muscle strength. So far, there is currently no officially approved medication for treating muscle strength loss. The active vitamin D analogues are promising but inconsistent results have been reported in previous studies. The present study was to meta-analyze the effect of active vitamin D analogues on muscle strength and falls in elderly people.MethodsThe protocol was registered with PROSPERO (record number: CRD42021266978). We searched two databases including PubMed and Cochrane Library up until August 2023. Risk ratio (RR) and standardized mean difference (SMD) with 95% confidence intervals (95% CI) were used to assess the effects of active vitamin D analogues on muscle strength or falls.ResultsRegarding the effects of calcitriol (n= 1), alfacalcidol (n= 1) and eldecalcitol (n= 1) on falls, all included randomized controlled trials (RCT) recruited 771 participants. Regarding the effects of the effects of calcitriol (n= 4), alfacalcidol (n= 3) and eldecalcitol (n= 3) on muscle strength, all included RCTs recruited 2431 participants. The results showed that in the pooled analysis of three active vitamin D analogues, active vitamin D analogues reduced the risk of fall by 19%. Due to a lack of sufficient data, no separate subgroup analysis was conducted on the effect of each active vitamin D analogue on falls. In the pooled and separate analysis of active vitamin D analogues, no significant effects were found on global muscle, hand grip, and back extensor strength. However, a significant enhancement of quadriceps strength was observed in the pooled analysis and separate analysis of alfacalcidol and eldecalcitol. The separate subgroup analysis on the impact of calcitriol on the quadriceps strength was not performed due to the lack to sufficient data. The results of pooled and separate subgroup analysis of active vitamin D analogues with or without calcium supplementation showed that calcium supplementation did not affect the effect of vitamin D on muscle strength.ConclusionsThe use of active vitamin D analogues does not improve global muscle, hand grip, and back extensor strength but improves quadriceps strength and reduces risk of falls in elderly population. |
| first_indexed | 2024-03-08T09:06:34Z |
| format | Article |
| id | doaj.art-93d0ea05ff7f4857a9ea543daa6dda61 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-08T09:06:34Z |
| publishDate | 2024-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-93d0ea05ff7f4857a9ea543daa6dda612024-02-01T04:38:17ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922024-02-011510.3389/fendo.2024.13276231327623Effects of active vitamin D analogues on muscle strength and falls in elderly people: an updated meta-analysisAn XiongHaibo LiMiaoying LinFeng XuXuedi XiaDexing DaiRuoman SunYali LingLei QiuRui WangYa DingZhongjian XieBackgroundElderly people are at high risk of falls due to decreased muscle strength. So far, there is currently no officially approved medication for treating muscle strength loss. The active vitamin D analogues are promising but inconsistent results have been reported in previous studies. The present study was to meta-analyze the effect of active vitamin D analogues on muscle strength and falls in elderly people.MethodsThe protocol was registered with PROSPERO (record number: CRD42021266978). We searched two databases including PubMed and Cochrane Library up until August 2023. Risk ratio (RR) and standardized mean difference (SMD) with 95% confidence intervals (95% CI) were used to assess the effects of active vitamin D analogues on muscle strength or falls.ResultsRegarding the effects of calcitriol (n= 1), alfacalcidol (n= 1) and eldecalcitol (n= 1) on falls, all included randomized controlled trials (RCT) recruited 771 participants. Regarding the effects of the effects of calcitriol (n= 4), alfacalcidol (n= 3) and eldecalcitol (n= 3) on muscle strength, all included RCTs recruited 2431 participants. The results showed that in the pooled analysis of three active vitamin D analogues, active vitamin D analogues reduced the risk of fall by 19%. Due to a lack of sufficient data, no separate subgroup analysis was conducted on the effect of each active vitamin D analogue on falls. In the pooled and separate analysis of active vitamin D analogues, no significant effects were found on global muscle, hand grip, and back extensor strength. However, a significant enhancement of quadriceps strength was observed in the pooled analysis and separate analysis of alfacalcidol and eldecalcitol. The separate subgroup analysis on the impact of calcitriol on the quadriceps strength was not performed due to the lack to sufficient data. The results of pooled and separate subgroup analysis of active vitamin D analogues with or without calcium supplementation showed that calcium supplementation did not affect the effect of vitamin D on muscle strength.ConclusionsThe use of active vitamin D analogues does not improve global muscle, hand grip, and back extensor strength but improves quadriceps strength and reduces risk of falls in elderly population.https://www.frontiersin.org/articles/10.3389/fendo.2024.1327623/fullvitamin D analoguesfallsmuscle strengthrandomized controlled trialsmeta-analysis |
| spellingShingle | An Xiong Haibo Li Miaoying Lin Feng Xu Xuedi Xia Dexing Dai Ruoman Sun Yali Ling Lei Qiu Rui Wang Ya Ding Zhongjian Xie Effects of active vitamin D analogues on muscle strength and falls in elderly people: an updated meta-analysis Frontiers in Endocrinology vitamin D analogues falls muscle strength randomized controlled trials meta-analysis |
| title | Effects of active vitamin D analogues on muscle strength and falls in elderly people: an updated meta-analysis |
| title_full | Effects of active vitamin D analogues on muscle strength and falls in elderly people: an updated meta-analysis |
| title_fullStr | Effects of active vitamin D analogues on muscle strength and falls in elderly people: an updated meta-analysis |
| title_full_unstemmed | Effects of active vitamin D analogues on muscle strength and falls in elderly people: an updated meta-analysis |
| title_short | Effects of active vitamin D analogues on muscle strength and falls in elderly people: an updated meta-analysis |
| title_sort | effects of active vitamin d analogues on muscle strength and falls in elderly people an updated meta analysis |
| topic | vitamin D analogues falls muscle strength randomized controlled trials meta-analysis |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2024.1327623/full |
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