α-Gal antigen-deficient rabbits with GGTA1 gene disruption via CRISPR/Cas9

α-Gal antigen-deficient rabbits with GGTA1 gene disruption via CRISPR/Cas9

Abstract Background Previous studies have identified the carbohydrate epitope Galα1–3Galβ1–4GlcNAc-R (termed the α-galactosyl epitope), known as the α-Gal antigen as the primary xenoantigen recognized by the human immune system. The α-Gal antigen is regulated by galactosyltransferase (GGTA1), and α-...

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Main Authors: Lina Wei, Yufeng Mu, Jichao Deng, Yong Wu, Ying Qiao, Kun Zhang, Xuewen Wang, Wenpeng Huang, Anliang Shao, Liang Chen, Yang Zhang, Zhanjun Li, Liangxue Lai, Shuxin Qu, Liming Xu
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Genomic Data
Subjects:
α-Gal antigen
GGTA1 gene
Gal antigen-deficient rabbit
Immunogenicity
CRISPR/Cas9
Implant response
Online Access:https://doi.org/10.1186/s12863-022-01068-4

Internet

https://doi.org/10.1186/s12863-022-01068-4

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