Pulmonary artery dilatation in different causes of pulmonary hypertension
Abstract Pulmonary artery (PA) dilatation is commonly observed in patients with pulmonary hypertension (PH). However, the clinical aspects of PA dilatation in various etiology of PH remain unknown. In this study, we investigated the clinical and imaging characteristics of 1018 patients with differen...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-10-01
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| Series: | Pulmonary Circulation |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/pul2.12313 |
| _version_ | 1797373485880705024 |
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| author | Qunying Xi Zhihong Liu Changming Xiong Qin Luo Zhihui Zhao Qing Zhao Tao Yang Qixian Zeng Pingwei Li Luwen Qiu |
| author_facet | Qunying Xi Zhihong Liu Changming Xiong Qin Luo Zhihui Zhao Qing Zhao Tao Yang Qixian Zeng Pingwei Li Luwen Qiu |
| author_sort | Qunying Xi |
| collection | DOAJ |
| description | Abstract Pulmonary artery (PA) dilatation is commonly observed in patients with pulmonary hypertension (PH). However, the clinical aspects of PA dilatation in various etiology of PH remain unknown. In this study, we investigated the clinical and imaging characteristics of 1018 patients with different subtypes of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). The independent determinants for all‐cause death were identified using univariate and multivariate Cox proportional hazard models. PA dilatation was identified in 88.8% of the patients, and 27.2% had a PA diameter/ascending aorta diameter ratio greater than 1.5. PA diameter was shown to be significantly correlated with hemodynamic parameters and symptom duration in idiopathic PAH patients. PA diameter only correlated with pulmonary circulation volume in patients with PAH associated with congenital heart disease. PA diameter correlated with symptom duration and right ventricular end‐diastolic dimension in CTEPH patients. PA diameter correlated with right ventricular end‐diastolic dimension in patients with PAH associated with connective tissue disease. Only 6‐min walk distance, but not PA dilatation, predicts all‐cause death independently. In conclusion, PA dilatation is a common finding in PH patients. The clinical feature of PA dilatation varies greatly between PH types. PA dilatation is not associated with all‐cause death. |
| first_indexed | 2024-03-08T18:51:06Z |
| format | Article |
| id | doaj.art-93d3675b0f0741488699520eca059da3 |
| institution | Directory Open Access Journal |
| issn | 2045-8940 |
| language | English |
| last_indexed | 2024-03-08T18:51:06Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | Pulmonary Circulation |
| spelling | doaj.art-93d3675b0f0741488699520eca059da32023-12-28T19:02:35ZengWileyPulmonary Circulation2045-89402023-10-01134n/an/a10.1002/pul2.12313Pulmonary artery dilatation in different causes of pulmonary hypertensionQunying Xi0Zhihong Liu1Changming Xiong2Qin Luo3Zhihui Zhao4Qing Zhao5Tao Yang6Qixian Zeng7Pingwei Li8Luwen Qiu9Pulmonary Vascular Diseases Ward, Fuwai Hospital Chinese Academy of Medical Sciences Shenzhen ChinaCenter for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaCenter for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaCenter for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaCenter for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaCenter for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaCenter for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaCenter for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing ChinaPulmonary Vascular Diseases Ward, Fuwai Hospital Chinese Academy of Medical Sciences Shenzhen ChinaPulmonary Vascular Diseases Ward, Fuwai Hospital Chinese Academy of Medical Sciences Shenzhen ChinaAbstract Pulmonary artery (PA) dilatation is commonly observed in patients with pulmonary hypertension (PH). However, the clinical aspects of PA dilatation in various etiology of PH remain unknown. In this study, we investigated the clinical and imaging characteristics of 1018 patients with different subtypes of pulmonary arterial hypertension (PAH) and chronic thromboembolic pulmonary hypertension (CTEPH). The independent determinants for all‐cause death were identified using univariate and multivariate Cox proportional hazard models. PA dilatation was identified in 88.8% of the patients, and 27.2% had a PA diameter/ascending aorta diameter ratio greater than 1.5. PA diameter was shown to be significantly correlated with hemodynamic parameters and symptom duration in idiopathic PAH patients. PA diameter only correlated with pulmonary circulation volume in patients with PAH associated with congenital heart disease. PA diameter correlated with symptom duration and right ventricular end‐diastolic dimension in CTEPH patients. PA diameter correlated with right ventricular end‐diastolic dimension in patients with PAH associated with connective tissue disease. Only 6‐min walk distance, but not PA dilatation, predicts all‐cause death independently. In conclusion, PA dilatation is a common finding in PH patients. The clinical feature of PA dilatation varies greatly between PH types. PA dilatation is not associated with all‐cause death.https://doi.org/10.1002/pul2.12313clinical characteristicsclinical classificationpulmonary artery dilatationpulmonary hypertension |
| spellingShingle | Qunying Xi Zhihong Liu Changming Xiong Qin Luo Zhihui Zhao Qing Zhao Tao Yang Qixian Zeng Pingwei Li Luwen Qiu Pulmonary artery dilatation in different causes of pulmonary hypertension Pulmonary Circulation clinical characteristics clinical classification pulmonary artery dilatation pulmonary hypertension |
| title | Pulmonary artery dilatation in different causes of pulmonary hypertension |
| title_full | Pulmonary artery dilatation in different causes of pulmonary hypertension |
| title_fullStr | Pulmonary artery dilatation in different causes of pulmonary hypertension |
| title_full_unstemmed | Pulmonary artery dilatation in different causes of pulmonary hypertension |
| title_short | Pulmonary artery dilatation in different causes of pulmonary hypertension |
| title_sort | pulmonary artery dilatation in different causes of pulmonary hypertension |
| topic | clinical characteristics clinical classification pulmonary artery dilatation pulmonary hypertension |
| url | https://doi.org/10.1002/pul2.12313 |
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