DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity

DHX15-independent roles for TFIP11 in U6 snRNA modification, U4/U6.U5 tri-snRNP assembly and pre-mRNA splicing fidelity

In yeast, TFIP11 and DHX15 promote the disassembly of spliceosome complex after splicing is completed. Here the authors show that human TFIP11 functions independently of DHX15 and is required for U6 snRNA 2’-O-methylation and U4/U6.U5 tri-snRNP assembly.

Bibliographic Details
Main Authors: Amandine Duchemin, Tina O’Grady, Sarah Hanache, Agnès Mereau, Marc Thiry, Ludivine Wacheul, Catherine Michaux, Eric Perpète, Eric Hervouet, Paul Peixoto, Felix G. M. Ernst, Yann Audic, Franck Dequiedt, Denis L. J. Lafontaine, Denis Mottet
Format: Article
Language:English
Published: Nature Portfolio 2021-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-26932-2

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