Primary Retrobulbar Leiomyosarcoma in a Dog: A Case Report
A 2-year-old female Mongrel dog weighing 3.12 kg presented with a 2-month history of progressive exophthalmos of the left eye and periorbital swelling. Fine-needle aspiration cytology of the affected tissue revealed atypical cells of suspected malignant mesenchymal tumor origin. Computed tomography...
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| Format: | Article |
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MDPI AG
2020-09-01
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| Series: | Veterinary Sciences |
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| Online Access: | https://www.mdpi.com/2306-7381/7/4/145 |
| _version_ | 1827705279377047552 |
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| author | Joong-Hyun Song Do-Hyeon Yu Dong-In Jung |
| author_facet | Joong-Hyun Song Do-Hyeon Yu Dong-In Jung |
| author_sort | Joong-Hyun Song |
| collection | DOAJ |
| description | A 2-year-old female Mongrel dog weighing 3.12 kg presented with a 2-month history of progressive exophthalmos of the left eye and periorbital swelling. Fine-needle aspiration cytology of the affected tissue revealed atypical cells of suspected malignant mesenchymal tumor origin. Computed tomography and magnetic resonance imaging revealed an ill-demarcated soft tissue mass in the left retrobulbar space extending into the nasal cavity and into the frontal lobes of the brain with destruction of the adjacent cribriform plate and the basisphenoid bone. Histopathological features of the tumor were consistent with the diagnosis of undifferentiated sarcoma. The tumor cells were immunoreactive for vimentin, smooth muscle actin, and desmin and negative for S100. These findings were mostly consistent with leiomyosarcoma arising from the smooth muscle on the retrobulbar tissues. Primary retrobulbar leiomyosarcoma is an extremely rare tumor in dogs. To expand our knowledge of retrobulbar leiomyosarcoma in dogs, we have described its clinical, diagnostic imaging, histopathological, and immunohistochemical characteristics in a dog. |
| first_indexed | 2024-03-10T16:00:55Z |
| format | Article |
| id | doaj.art-93d43f6a1a9a4a40844b6ce1d206f43e |
| institution | Directory Open Access Journal |
| issn | 2306-7381 |
| language | English |
| last_indexed | 2024-03-10T16:00:55Z |
| publishDate | 2020-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Veterinary Sciences |
| spelling | doaj.art-93d43f6a1a9a4a40844b6ce1d206f43e2023-11-20T15:19:40ZengMDPI AGVeterinary Sciences2306-73812020-09-017414510.3390/vetsci7040145Primary Retrobulbar Leiomyosarcoma in a Dog: A Case ReportJoong-Hyun Song0Do-Hyeon Yu1Dong-In Jung2Institute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, KoreaInstitute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, KoreaInstitute of Animal Medicine, College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, KoreaA 2-year-old female Mongrel dog weighing 3.12 kg presented with a 2-month history of progressive exophthalmos of the left eye and periorbital swelling. Fine-needle aspiration cytology of the affected tissue revealed atypical cells of suspected malignant mesenchymal tumor origin. Computed tomography and magnetic resonance imaging revealed an ill-demarcated soft tissue mass in the left retrobulbar space extending into the nasal cavity and into the frontal lobes of the brain with destruction of the adjacent cribriform plate and the basisphenoid bone. Histopathological features of the tumor were consistent with the diagnosis of undifferentiated sarcoma. The tumor cells were immunoreactive for vimentin, smooth muscle actin, and desmin and negative for S100. These findings were mostly consistent with leiomyosarcoma arising from the smooth muscle on the retrobulbar tissues. Primary retrobulbar leiomyosarcoma is an extremely rare tumor in dogs. To expand our knowledge of retrobulbar leiomyosarcoma in dogs, we have described its clinical, diagnostic imaging, histopathological, and immunohistochemical characteristics in a dog.https://www.mdpi.com/2306-7381/7/4/145CTdogsimmunohistochemistryleiomyosarcomaMRIretrobulbar tumor |
| spellingShingle | Joong-Hyun Song Do-Hyeon Yu Dong-In Jung Primary Retrobulbar Leiomyosarcoma in a Dog: A Case Report Veterinary Sciences CT dogs immunohistochemistry leiomyosarcoma MRI retrobulbar tumor |
| title | Primary Retrobulbar Leiomyosarcoma in a Dog: A Case Report |
| title_full | Primary Retrobulbar Leiomyosarcoma in a Dog: A Case Report |
| title_fullStr | Primary Retrobulbar Leiomyosarcoma in a Dog: A Case Report |
| title_full_unstemmed | Primary Retrobulbar Leiomyosarcoma in a Dog: A Case Report |
| title_short | Primary Retrobulbar Leiomyosarcoma in a Dog: A Case Report |
| title_sort | primary retrobulbar leiomyosarcoma in a dog a case report |
| topic | CT dogs immunohistochemistry leiomyosarcoma MRI retrobulbar tumor |
| url | https://www.mdpi.com/2306-7381/7/4/145 |
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