Higher Levels of Secretory IgA Are Associated with Low Disease Activity Index in Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis
IntroductionBoth reactive arthritis (ReA) and undifferentiated spondyloarthritis (uSpA) belong to the group of autoinflammatory diseases called spondyloarthritis (SpA). Hypotheses have been proposed about a relationship between the intestinal mucosa and inflammation of joint tissues. The role of imm...
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Frontiers Media S.A.
2017-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00476/full |
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| author | Consuelo Romero-Sánchez Consuelo Romero-Sánchez Consuelo Romero-Sánchez Fabián Salas-Cuestas Wilson Bautista-Molano Wilson Bautista-Molano Juan M. Bello-Gualtero Juan M. Bello-Gualtero Ivonne Arias Diana Marcela Castillo Lorena Chila-Moreno Rafael Valle-Oñate Rafael Valle-Oñate Daniel Herrera |
| author_facet | Consuelo Romero-Sánchez Consuelo Romero-Sánchez Consuelo Romero-Sánchez Fabián Salas-Cuestas Wilson Bautista-Molano Wilson Bautista-Molano Juan M. Bello-Gualtero Juan M. Bello-Gualtero Ivonne Arias Diana Marcela Castillo Lorena Chila-Moreno Rafael Valle-Oñate Rafael Valle-Oñate Daniel Herrera |
| author_sort | Consuelo Romero-Sánchez |
| collection | DOAJ |
| description | IntroductionBoth reactive arthritis (ReA) and undifferentiated spondyloarthritis (uSpA) belong to the group of autoinflammatory diseases called spondyloarthritis (SpA). Hypotheses have been proposed about a relationship between the intestinal mucosa and inflammation of joint tissues. The role of immunoglobulin IgA or secretory immunoglobulin A (SIgA) in the inflammatory and/or clinical activity of patients with SpA remains poorly understood.ObjectiveTo evaluate the status of total IgA and SIgA, and the association among the levels of SIgA, IgA, IgA anti-Chlamydia trachomatis, and anti-Shigella spp. with the disease activity measures, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, was compared in a cohort of patients with ReA and uSpA and healthy subjects.MethodsThis was a cross-sectional study. The serum concentrations of SIgA, IgA anti-C. trachomatis, anti-Shigella spp., and total IgA were measured. Disease activity was measured in each patient by means of Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS). Statistical analysis did include as bivariate evaluation, comparisons by Student’s t-test, Kruskal–Wallis test, and U Mann–Whitney test, with a multivariate evaluation by principal components analysis (PCA). A correlation analysis was carried out using the Pearson correlation coefficient and a linear regression models. All analysis were made using Stata version 11.2® for Windows, R V3.3.21. Statistical significance was defined a p-value <0.05.ResultsIn all, 46 patients (78.2% men; mean age, 34.8 ± 12.3 years) and 53 controls (41% men; mean age, 32 ± 11.4 years) were included in the study. The mean serum levels of SIgA were higher in SpA patients than in healthy subjects (p < 0.001). Only SIgA levels correlated with disease activity: BASDAI (r = −0.42, p = 0.0046), ASDAS-CRP (r = −0.37, p = 0.014), and ASDAS-ESR (r = −0.45, p = 0.0021). The negative correlation between SIgA and all activity indices was higher in HLA-B27-positive patients (BASDAI r = −0.70, p = 0.0009, ASDAS-CRP r = −0.58, p = 0.0093, and ASDAS-ESR r = −0.57, p = 0.0083). The PCA showed three factors: the first component was constituted by variables referred as clinical activity measures, the second did include the serological activity markers, and the last component was compounded by age and symptoms time.ConclusionElevated serum levels of SIgA were found to be related with low disease activity in patients with ReA and uSpA. |
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| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-13T13:43:31Z |
| publishDate | 2017-04-01 |
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| spelling | doaj.art-93d6d2de6c36447fb0c6e2aaf90b653f2022-12-22T02:44:32ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-04-01810.3389/fimmu.2017.00476237084Higher Levels of Secretory IgA Are Associated with Low Disease Activity Index in Patients with Reactive Arthritis and Undifferentiated SpondyloarthritisConsuelo Romero-Sánchez0Consuelo Romero-Sánchez1Consuelo Romero-Sánchez2Fabián Salas-Cuestas3Wilson Bautista-Molano4Wilson Bautista-Molano5Juan M. Bello-Gualtero6Juan M. Bello-Gualtero7Ivonne Arias8Diana Marcela Castillo9Lorena Chila-Moreno10Rafael Valle-Oñate11Rafael Valle-Oñate12Daniel Herrera13Faculty of Medicine, Universidad Militar Nueva Granada, Bogotá, ColombiaUnit of Oral Basic Investigation-UIBO, School of Dentistry, Universidad El Bosque, Bogotá, ColombiaDepartment of Rheumatology and Immunology, Hospital Militar Central, Bogotá, ColombiaFaculty of Medicine, Universidad Militar Nueva Granada, Bogotá, ColombiaFaculty of Medicine, Universidad Militar Nueva Granada, Bogotá, ColombiaUnit of Oral Basic Investigation-UIBO, School of Dentistry, Universidad El Bosque, Bogotá, ColombiaFaculty of Medicine, Universidad Militar Nueva Granada, Bogotá, ColombiaDepartment of Rheumatology and Immunology, Hospital Militar Central, Bogotá, ColombiaSchool of Medicine, Instituto de Genética Humana, Pontificia Universidad Javeriana, Bogotá, ColombiaUnit of Oral Basic Investigation-UIBO, School of Dentistry, Universidad El Bosque, Bogotá, ColombiaUnit of Oral Basic Investigation-UIBO, School of Dentistry, Universidad El Bosque, Bogotá, ColombiaFaculty of Medicine, Universidad Militar Nueva Granada, Bogotá, ColombiaDepartment of Rheumatology and Immunology, Hospital Militar Central, Bogotá, ColombiaSchool of Medicine, Instituto de Genética Humana, Pontificia Universidad Javeriana, Bogotá, ColombiaIntroductionBoth reactive arthritis (ReA) and undifferentiated spondyloarthritis (uSpA) belong to the group of autoinflammatory diseases called spondyloarthritis (SpA). Hypotheses have been proposed about a relationship between the intestinal mucosa and inflammation of joint tissues. The role of immunoglobulin IgA or secretory immunoglobulin A (SIgA) in the inflammatory and/or clinical activity of patients with SpA remains poorly understood.ObjectiveTo evaluate the status of total IgA and SIgA, and the association among the levels of SIgA, IgA, IgA anti-Chlamydia trachomatis, and anti-Shigella spp. with the disease activity measures, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels, was compared in a cohort of patients with ReA and uSpA and healthy subjects.MethodsThis was a cross-sectional study. The serum concentrations of SIgA, IgA anti-C. trachomatis, anti-Shigella spp., and total IgA were measured. Disease activity was measured in each patient by means of Bath Ankylosing Spondylitis Disease Activity Index (BASDAI) and Ankylosing Spondylitis Disease Activity Score (ASDAS). Statistical analysis did include as bivariate evaluation, comparisons by Student’s t-test, Kruskal–Wallis test, and U Mann–Whitney test, with a multivariate evaluation by principal components analysis (PCA). A correlation analysis was carried out using the Pearson correlation coefficient and a linear regression models. All analysis were made using Stata version 11.2® for Windows, R V3.3.21. Statistical significance was defined a p-value <0.05.ResultsIn all, 46 patients (78.2% men; mean age, 34.8 ± 12.3 years) and 53 controls (41% men; mean age, 32 ± 11.4 years) were included in the study. The mean serum levels of SIgA were higher in SpA patients than in healthy subjects (p < 0.001). Only SIgA levels correlated with disease activity: BASDAI (r = −0.42, p = 0.0046), ASDAS-CRP (r = −0.37, p = 0.014), and ASDAS-ESR (r = −0.45, p = 0.0021). The negative correlation between SIgA and all activity indices was higher in HLA-B27-positive patients (BASDAI r = −0.70, p = 0.0009, ASDAS-CRP r = −0.58, p = 0.0093, and ASDAS-ESR r = −0.57, p = 0.0083). The PCA showed three factors: the first component was constituted by variables referred as clinical activity measures, the second did include the serological activity markers, and the last component was compounded by age and symptoms time.ConclusionElevated serum levels of SIgA were found to be related with low disease activity in patients with ReA and uSpA.http://journal.frontiersin.org/article/10.3389/fimmu.2017.00476/fullspondyloarthritisankylosing spondylitissecretory immunoglobulin Aimmunoglobulin AHLA-B27severity of illness index |
| spellingShingle | Consuelo Romero-Sánchez Consuelo Romero-Sánchez Consuelo Romero-Sánchez Fabián Salas-Cuestas Wilson Bautista-Molano Wilson Bautista-Molano Juan M. Bello-Gualtero Juan M. Bello-Gualtero Ivonne Arias Diana Marcela Castillo Lorena Chila-Moreno Rafael Valle-Oñate Rafael Valle-Oñate Daniel Herrera Higher Levels of Secretory IgA Are Associated with Low Disease Activity Index in Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis Frontiers in Immunology spondyloarthritis ankylosing spondylitis secretory immunoglobulin A immunoglobulin A HLA-B27 severity of illness index |
| title | Higher Levels of Secretory IgA Are Associated with Low Disease Activity Index in Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis |
| title_full | Higher Levels of Secretory IgA Are Associated with Low Disease Activity Index in Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis |
| title_fullStr | Higher Levels of Secretory IgA Are Associated with Low Disease Activity Index in Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis |
| title_full_unstemmed | Higher Levels of Secretory IgA Are Associated with Low Disease Activity Index in Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis |
| title_short | Higher Levels of Secretory IgA Are Associated with Low Disease Activity Index in Patients with Reactive Arthritis and Undifferentiated Spondyloarthritis |
| title_sort | higher levels of secretory iga are associated with low disease activity index in patients with reactive arthritis and undifferentiated spondyloarthritis |
| topic | spondyloarthritis ankylosing spondylitis secretory immunoglobulin A immunoglobulin A HLA-B27 severity of illness index |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00476/full |
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