Incidental findings on coronary computed tomography in women with selected reproductive disorders
Abstract Objective To determine the prevalence of incidental findings (IFs) on coronary computed tomography (CCT) in women aged 45–55 years and previously diagnosed with reproductive disorders such as polycystic ovary syndrome (PCOS), premature ovarian insufficiency (POI) or preeclampsia (PE). Metho...
| Main Authors: | , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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SpringerOpen
2022-06-01
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| Series: | Insights into Imaging |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13244-022-01238-z |
| _version_ | 1811242906230456320 |
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| author | Kim van der Ham Charissa van Zwol-Janssens Birgitta K. Velthuis Maria P. H. Koster Yvonne V. Louwers Dustin Goei Maurits S. H. Blomjous Arie Franx Bart C. J. M. Fauser Eric Boersma Joop S. E. Laven Ricardo P. J. Budde the CREW Consortium |
| author_facet | Kim van der Ham Charissa van Zwol-Janssens Birgitta K. Velthuis Maria P. H. Koster Yvonne V. Louwers Dustin Goei Maurits S. H. Blomjous Arie Franx Bart C. J. M. Fauser Eric Boersma Joop S. E. Laven Ricardo P. J. Budde the CREW Consortium |
| author_sort | Kim van der Ham |
| collection | DOAJ |
| description | Abstract Objective To determine the prevalence of incidental findings (IFs) on coronary computed tomography (CCT) in women aged 45–55 years and previously diagnosed with reproductive disorders such as polycystic ovary syndrome (PCOS), premature ovarian insufficiency (POI) or preeclampsia (PE). Methods A total of 486 middle-aged women with PCOS (n = 101), POI (n = 97) or a history of PE (n = 288) underwent a CCT as part of a prior prospective study. IFs were categorized by their significance (minor, moderate and major). Follow-up information was collected from patients’ records. To investigate the impact of different field of views (FOVs), a subset of scans was analyzed in full FOV and small FOV. Results In 96/486 (19.8%) women, one or more IFs were detected, of which 54/486 (11.1%) were classified as moderate/major and 48/486 (9.9%) required follow-up. A moderate/major IF was detected in 16/101 (15.9%) women with PCOS, 13/97 (13.4%) women with POI and 25/288 (8.7%) women with a history of PE. In 78 women with an IF detected in the full FOV, the IF was still visible in 60 (76.9%) women in the small FOV. In the full FOV, 46 women required follow-up, but using the small FOV this was reduced to 30 women. Conclusion Using CCT as a cardiovascular disease screening tool in women with selected reproductive disorders increases the probability of detecting IFs that can cause anxiety and may generate extra costs, but can also reveal clinically relevant findings. Using a small FOV centered around the heart resulted in a lower prevalence of IFs and required less follow-up. |
| first_indexed | 2024-04-12T13:58:50Z |
| format | Article |
| id | doaj.art-93d79ab41b7244aab254c983b375e72e |
| institution | Directory Open Access Journal |
| issn | 1869-4101 |
| language | English |
| last_indexed | 2024-04-12T13:58:50Z |
| publishDate | 2022-06-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Insights into Imaging |
| spelling | doaj.art-93d79ab41b7244aab254c983b375e72e2022-12-22T03:30:16ZengSpringerOpenInsights into Imaging1869-41012022-06-0113111010.1186/s13244-022-01238-zIncidental findings on coronary computed tomography in women with selected reproductive disordersKim van der Ham0Charissa van Zwol-Janssens1Birgitta K. Velthuis2Maria P. H. Koster3Yvonne V. Louwers4Dustin Goei5Maurits S. H. Blomjous6Arie Franx7Bart C. J. M. Fauser8Eric Boersma9Joop S. E. Laven10Ricardo P. J. Budde11the CREW ConsortiumDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical CenterDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical CenterDepartment of Radiology, University Medical Center Utrecht, University of UtrechtDepartment of Obstetrics and Gynaecology, Erasmus University Medical CenterDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical CenterDepartment of Radiology, University Medical Center Utrecht, University of UtrechtDepartment of Radiology and Nuclear Medicine, Erasmus University Medical CenterDepartment of Obstetrics and Gynaecology, Erasmus University Medical CenterDepartment of Reproductive Medicine and Gynaecology, Department of Obstetrics and Gynaecology, University Medical Center Utrecht, University of UtrechtDepartment of Cardiology, Erasmus University Medical CenterDivision of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynaecology, Erasmus University Medical CenterDepartment of Radiology and Nuclear Medicine, Erasmus University Medical CenterAbstract Objective To determine the prevalence of incidental findings (IFs) on coronary computed tomography (CCT) in women aged 45–55 years and previously diagnosed with reproductive disorders such as polycystic ovary syndrome (PCOS), premature ovarian insufficiency (POI) or preeclampsia (PE). Methods A total of 486 middle-aged women with PCOS (n = 101), POI (n = 97) or a history of PE (n = 288) underwent a CCT as part of a prior prospective study. IFs were categorized by their significance (minor, moderate and major). Follow-up information was collected from patients’ records. To investigate the impact of different field of views (FOVs), a subset of scans was analyzed in full FOV and small FOV. Results In 96/486 (19.8%) women, one or more IFs were detected, of which 54/486 (11.1%) were classified as moderate/major and 48/486 (9.9%) required follow-up. A moderate/major IF was detected in 16/101 (15.9%) women with PCOS, 13/97 (13.4%) women with POI and 25/288 (8.7%) women with a history of PE. In 78 women with an IF detected in the full FOV, the IF was still visible in 60 (76.9%) women in the small FOV. In the full FOV, 46 women required follow-up, but using the small FOV this was reduced to 30 women. Conclusion Using CCT as a cardiovascular disease screening tool in women with selected reproductive disorders increases the probability of detecting IFs that can cause anxiety and may generate extra costs, but can also reveal clinically relevant findings. Using a small FOV centered around the heart resulted in a lower prevalence of IFs and required less follow-up.https://doi.org/10.1186/s13244-022-01238-zPolycystic ovary syndromePremature ovarian insufficiencyPreeclampsiaIncidental findingsComputed tomography |
| spellingShingle | Kim van der Ham Charissa van Zwol-Janssens Birgitta K. Velthuis Maria P. H. Koster Yvonne V. Louwers Dustin Goei Maurits S. H. Blomjous Arie Franx Bart C. J. M. Fauser Eric Boersma Joop S. E. Laven Ricardo P. J. Budde the CREW Consortium Incidental findings on coronary computed tomography in women with selected reproductive disorders Insights into Imaging Polycystic ovary syndrome Premature ovarian insufficiency Preeclampsia Incidental findings Computed tomography |
| title | Incidental findings on coronary computed tomography in women with selected reproductive disorders |
| title_full | Incidental findings on coronary computed tomography in women with selected reproductive disorders |
| title_fullStr | Incidental findings on coronary computed tomography in women with selected reproductive disorders |
| title_full_unstemmed | Incidental findings on coronary computed tomography in women with selected reproductive disorders |
| title_short | Incidental findings on coronary computed tomography in women with selected reproductive disorders |
| title_sort | incidental findings on coronary computed tomography in women with selected reproductive disorders |
| topic | Polycystic ovary syndrome Premature ovarian insufficiency Preeclampsia Incidental findings Computed tomography |
| url | https://doi.org/10.1186/s13244-022-01238-z |
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