Prevalence of postpartum anaemia and iron deficiency by serum ferritin, soluble transferrin receptor and total body iron, and associations with ethnicity and clinical factors: a Norwegian population-based cohort study
Worldwide, there are limited data on the prevalence of postpartum anaemia and iron status. The aims of the present study were to assess the prevalence of anaemia and iron deficiency (ID) by three iron indicators 14 weeks postpartum, their relations to haemoglobin (Hb) and associations with ethnicity...
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Cambridge University Press
2022-01-01
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| Series: | Journal of Nutritional Science |
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| Online Access: | https://www.cambridge.org/core/product/identifier/S2048679022000453/type/journal_article |
| _version_ | 1827994567833550848 |
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| author | Marthe-Lise Næss-Andresen Anne Karen Jenum Jens Petter Berg Ragnhild Sørum Falk Line Sletner |
| author_facet | Marthe-Lise Næss-Andresen Anne Karen Jenum Jens Petter Berg Ragnhild Sørum Falk Line Sletner |
| author_sort | Marthe-Lise Næss-Andresen |
| collection | DOAJ |
| description | Worldwide, there are limited data on the prevalence of postpartum anaemia and iron status. The aims of the present study were to assess the prevalence of anaemia and iron deficiency (ID) by three iron indicators 14 weeks postpartum, their relations to haemoglobin (Hb) and associations with ethnicity and clinical factors in a multi-ethnic population. We conducted a population-based cohort study of 573 women followed from early pregnancy. The prevalence of postpartum anaemia (Hb <12·0 g/dl) was 25 %. ID prevalence varied from 39 % by serum ferritin (SF <15 μg/l), to 19 % by soluble transferrin receptor (sTfR >4·4 mg/l) and 22 % by total body iron (TBI < 0 mg/kg). The mean Hb concentration was 12·8 g/dl in women with no ID, 12·6 g/dl in those with ID by SF only and 11·6 g/dl in those with ID by SF, sTfR and TBI. ID by sTfR and TBI defined by the current threshold values probably identified a more severe iron-deficient population compared with ID assessed by SF. Compared with Western Europeans, the prevalence of anaemia was at least the double in ethnic minorities (26–40 % v. 14 %; P < 0·01–0·05), and the prevalence of ID by sTfR and TBI, but not of ID by SF < 15 μg/l, was significantly higher in some minority groups. After adjustment for covariates, only South Asians had lower Hb and higher sTfR concentration. Insufficient iron intake, gestational anaemia or ID, and postpartum haemorrhage were associated with lower postpartum Hb concentration and poorer iron status. |
| first_indexed | 2024-04-10T04:43:07Z |
| format | Article |
| id | doaj.art-93d87d2be94f4f81b63897df5b4c81b7 |
| institution | Directory Open Access Journal |
| issn | 2048-6790 |
| language | English |
| last_indexed | 2024-04-10T04:43:07Z |
| publishDate | 2022-01-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | Journal of Nutritional Science |
| spelling | doaj.art-93d87d2be94f4f81b63897df5b4c81b72023-03-09T12:38:45ZengCambridge University PressJournal of Nutritional Science2048-67902022-01-011110.1017/jns.2022.45Prevalence of postpartum anaemia and iron deficiency by serum ferritin, soluble transferrin receptor and total body iron, and associations with ethnicity and clinical factors: a Norwegian population-based cohort studyMarthe-Lise Næss-Andresen0https://orcid.org/0000-0001-8149-6383Anne Karen Jenum1Jens Petter Berg2Ragnhild Sørum Falk3Line Sletner4Department of General Practice, Institute of Health and Society, University of Oslo, Oslo, NorwayGeneral Practice Research Unit, Department of General Practice, Institute of Health and Society, University of Oslo, Oslo, NorwayDepartment of Medical Biochemistry, Institute of Clinical Medicine, University of Oslo, Oslo, NorwayOslo Centre for Biostatistics and Epidemiology, Oslo University Hospital, Oslo, NorwayDepartment of Paediatric and Adolescents Medicine, Akershus University Hospital, Lørenskog, Norway Institute of Clinical Medicine, University of Oslo, Oslo, NorwayWorldwide, there are limited data on the prevalence of postpartum anaemia and iron status. The aims of the present study were to assess the prevalence of anaemia and iron deficiency (ID) by three iron indicators 14 weeks postpartum, their relations to haemoglobin (Hb) and associations with ethnicity and clinical factors in a multi-ethnic population. We conducted a population-based cohort study of 573 women followed from early pregnancy. The prevalence of postpartum anaemia (Hb <12·0 g/dl) was 25 %. ID prevalence varied from 39 % by serum ferritin (SF <15 μg/l), to 19 % by soluble transferrin receptor (sTfR >4·4 mg/l) and 22 % by total body iron (TBI < 0 mg/kg). The mean Hb concentration was 12·8 g/dl in women with no ID, 12·6 g/dl in those with ID by SF only and 11·6 g/dl in those with ID by SF, sTfR and TBI. ID by sTfR and TBI defined by the current threshold values probably identified a more severe iron-deficient population compared with ID assessed by SF. Compared with Western Europeans, the prevalence of anaemia was at least the double in ethnic minorities (26–40 % v. 14 %; P < 0·01–0·05), and the prevalence of ID by sTfR and TBI, but not of ID by SF < 15 μg/l, was significantly higher in some minority groups. After adjustment for covariates, only South Asians had lower Hb and higher sTfR concentration. Insufficient iron intake, gestational anaemia or ID, and postpartum haemorrhage were associated with lower postpartum Hb concentration and poorer iron status.https://www.cambridge.org/core/product/identifier/S2048679022000453/type/journal_articleAnaemiaCohortEthnic minoritiesIron deficiencyPostpartum iron status |
| spellingShingle | Marthe-Lise Næss-Andresen Anne Karen Jenum Jens Petter Berg Ragnhild Sørum Falk Line Sletner Prevalence of postpartum anaemia and iron deficiency by serum ferritin, soluble transferrin receptor and total body iron, and associations with ethnicity and clinical factors: a Norwegian population-based cohort study Journal of Nutritional Science Anaemia Cohort Ethnic minorities Iron deficiency Postpartum iron status |
| title | Prevalence of postpartum anaemia and iron deficiency by serum ferritin, soluble transferrin receptor and total body iron, and associations with ethnicity and clinical factors: a Norwegian population-based cohort study |
| title_full | Prevalence of postpartum anaemia and iron deficiency by serum ferritin, soluble transferrin receptor and total body iron, and associations with ethnicity and clinical factors: a Norwegian population-based cohort study |
| title_fullStr | Prevalence of postpartum anaemia and iron deficiency by serum ferritin, soluble transferrin receptor and total body iron, and associations with ethnicity and clinical factors: a Norwegian population-based cohort study |
| title_full_unstemmed | Prevalence of postpartum anaemia and iron deficiency by serum ferritin, soluble transferrin receptor and total body iron, and associations with ethnicity and clinical factors: a Norwegian population-based cohort study |
| title_short | Prevalence of postpartum anaemia and iron deficiency by serum ferritin, soluble transferrin receptor and total body iron, and associations with ethnicity and clinical factors: a Norwegian population-based cohort study |
| title_sort | prevalence of postpartum anaemia and iron deficiency by serum ferritin soluble transferrin receptor and total body iron and associations with ethnicity and clinical factors a norwegian population based cohort study |
| topic | Anaemia Cohort Ethnic minorities Iron deficiency Postpartum iron status |
| url | https://www.cambridge.org/core/product/identifier/S2048679022000453/type/journal_article |
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