Patient-specific hydrogel phantoms for the preoperative simulation of nephron-sparing surgery in Wilms’ tumor patients: A feasibility study
Nephron-sparing surgery (NSS) for Wilms Tumor patients has a positive surgical margin rate of 15.7–36.4%. Innovative approaches may reduce the occurrence of positive surgical margins in NSS and prevent these children from having additional radiotherapy and chemotherapy. The feasibility of performing...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-10-01
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| Series: | Annals of 3D Printed Medicine |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666964122000315 |
| _version_ | 1797984146311610368 |
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| author | Matthijs Fitski Cornelis P. van de Ven Caroline C.C. Hulsker Guus M.J. Bökkerink Cecilia E.J. Terwisscha van Scheltinga Marry M. van den Heuvel-Eibrink Annelies M.C. Mavinkurve-Groothuis Martine van Grotel Marc H.W.A. Wijnen Aart J. Klijn Alida F.W. van der Steeg |
| author_facet | Matthijs Fitski Cornelis P. van de Ven Caroline C.C. Hulsker Guus M.J. Bökkerink Cecilia E.J. Terwisscha van Scheltinga Marry M. van den Heuvel-Eibrink Annelies M.C. Mavinkurve-Groothuis Martine van Grotel Marc H.W.A. Wijnen Aart J. Klijn Alida F.W. van der Steeg |
| author_sort | Matthijs Fitski |
| collection | DOAJ |
| description | Nephron-sparing surgery (NSS) for Wilms Tumor patients has a positive surgical margin rate of 15.7–36.4%. Innovative approaches may reduce the occurrence of positive surgical margins in NSS and prevent these children from having additional radiotherapy and chemotherapy. The feasibility of performing mock surgery on patient-specific hydrogel phantoms of the kidney, tumor, and arterial vasculature for preoperative simulation of NSS was assessed in two patients. The development of patient-specific phantoms allowed the surgeon to practice surgery. Moreover, phantom specimens were assessed using MRI to understand the location and size of the smallest surgical margin. Surgeons reported that simulation surgery helped perform NSS safely and improved intraoperative tumor localization and resection planning. The technique is considered feasible and useful when preparing for NSS. In the future, this technique may further help to achieve negative surgical margins in NSS and may also allow the use of NSS in patients typically regarded as ineligible for this procedure. |
| first_indexed | 2024-04-11T06:57:59Z |
| format | Article |
| id | doaj.art-93d88d08f1074ffeaced153609350636 |
| institution | Directory Open Access Journal |
| issn | 2666-9641 |
| language | English |
| last_indexed | 2024-04-11T06:57:59Z |
| publishDate | 2022-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Annals of 3D Printed Medicine |
| spelling | doaj.art-93d88d08f1074ffeaced1536093506362022-12-22T04:38:57ZengElsevierAnnals of 3D Printed Medicine2666-96412022-10-018100077Patient-specific hydrogel phantoms for the preoperative simulation of nephron-sparing surgery in Wilms’ tumor patients: A feasibility studyMatthijs Fitski0Cornelis P. van de Ven1Caroline C.C. Hulsker2Guus M.J. Bökkerink3Cecilia E.J. Terwisscha van Scheltinga4Marry M. van den Heuvel-Eibrink5Annelies M.C. Mavinkurve-Groothuis6Martine van Grotel7Marc H.W.A. Wijnen8Aart J. Klijn9Alida F.W. van der Steeg10Princess Máxima Center for Pediatric Oncology, Utrecht, the Netherlands; Corresponding author.Princess Máxima Center for Pediatric Oncology, Utrecht, the NetherlandsPrincess Máxima Center for Pediatric Oncology, Utrecht, the NetherlandsPrincess Máxima Center for Pediatric Oncology, Utrecht, the NetherlandsPrincess Máxima Center for Pediatric Oncology, Utrecht, the NetherlandsPrincess Máxima Center for Pediatric Oncology, Utrecht, the NetherlandsPrincess Máxima Center for Pediatric Oncology, Utrecht, the NetherlandsPrincess Máxima Center for Pediatric Oncology, Utrecht, the NetherlandsPrincess Máxima Center for Pediatric Oncology, Utrecht, the NetherlandsDepartment of Pediatric Urology, University Medical Center Utrecht/Wilhelmina Children's Hospital, Utrecht, the NetherlandsPrincess Máxima Center for Pediatric Oncology, Utrecht, the NetherlandsNephron-sparing surgery (NSS) for Wilms Tumor patients has a positive surgical margin rate of 15.7–36.4%. Innovative approaches may reduce the occurrence of positive surgical margins in NSS and prevent these children from having additional radiotherapy and chemotherapy. The feasibility of performing mock surgery on patient-specific hydrogel phantoms of the kidney, tumor, and arterial vasculature for preoperative simulation of NSS was assessed in two patients. The development of patient-specific phantoms allowed the surgeon to practice surgery. Moreover, phantom specimens were assessed using MRI to understand the location and size of the smallest surgical margin. Surgeons reported that simulation surgery helped perform NSS safely and improved intraoperative tumor localization and resection planning. The technique is considered feasible and useful when preparing for NSS. In the future, this technique may further help to achieve negative surgical margins in NSS and may also allow the use of NSS in patients typically regarded as ineligible for this procedure.http://www.sciencedirect.com/science/article/pii/S2666964122000315Hydrogel PhantomsWilms TumorPediatric SurgeryNephron-sparing surgery |
| spellingShingle | Matthijs Fitski Cornelis P. van de Ven Caroline C.C. Hulsker Guus M.J. Bökkerink Cecilia E.J. Terwisscha van Scheltinga Marry M. van den Heuvel-Eibrink Annelies M.C. Mavinkurve-Groothuis Martine van Grotel Marc H.W.A. Wijnen Aart J. Klijn Alida F.W. van der Steeg Patient-specific hydrogel phantoms for the preoperative simulation of nephron-sparing surgery in Wilms’ tumor patients: A feasibility study Annals of 3D Printed Medicine Hydrogel Phantoms Wilms Tumor Pediatric Surgery Nephron-sparing surgery |
| title | Patient-specific hydrogel phantoms for the preoperative simulation of nephron-sparing surgery in Wilms’ tumor patients: A feasibility study |
| title_full | Patient-specific hydrogel phantoms for the preoperative simulation of nephron-sparing surgery in Wilms’ tumor patients: A feasibility study |
| title_fullStr | Patient-specific hydrogel phantoms for the preoperative simulation of nephron-sparing surgery in Wilms’ tumor patients: A feasibility study |
| title_full_unstemmed | Patient-specific hydrogel phantoms for the preoperative simulation of nephron-sparing surgery in Wilms’ tumor patients: A feasibility study |
| title_short | Patient-specific hydrogel phantoms for the preoperative simulation of nephron-sparing surgery in Wilms’ tumor patients: A feasibility study |
| title_sort | patient specific hydrogel phantoms for the preoperative simulation of nephron sparing surgery in wilms tumor patients a feasibility study |
| topic | Hydrogel Phantoms Wilms Tumor Pediatric Surgery Nephron-sparing surgery |
| url | http://www.sciencedirect.com/science/article/pii/S2666964122000315 |
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