Development and physical evaluation of Maytenus ilicifolia effervescent granules using factorial design
The medicinal plant Maytenus ilicifolia is a commonly used phytomedicine for the treatment of gastritis. The high dose required and low density of these extracts make necessary a daily intake of several capsules, hindering adherence to the medication. The purpose of this work was to develop a suitab...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Universidade de São Paulo
2014-04-01
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| Series: | Brazilian Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200243&lng=en&tlng=en |
| _version_ | 1818569507914907648 |
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| author | Marcilio Sérgio Soares da Cunha-Filho Pricila Castilho Gustmann Felipe Sanches Garcia Eliana Martins Lima Lívia Cristina Lira de Sá-Barreto |
| author_facet | Marcilio Sérgio Soares da Cunha-Filho Pricila Castilho Gustmann Felipe Sanches Garcia Eliana Martins Lima Lívia Cristina Lira de Sá-Barreto |
| author_sort | Marcilio Sérgio Soares da Cunha-Filho |
| collection | DOAJ |
| description | The medicinal plant Maytenus ilicifolia is a commonly used phytomedicine for the treatment of gastritis. The high dose required and low density of these extracts make necessary a daily intake of several capsules, hindering adherence to the medication. The purpose of this work was to develop a suitable dosage form for the administration of Maytenus ilicifolia using effervescent granules. A 23 factorial design was used to study the physical characteristics of the granules (particle size distribution, repose angle, Carr index, scanning electron microscopy and disintegration time). Moisture stability was also determined. According to the experimental design, granule size is the most important factor in determining the flow characteristics of effervescent granules. In turn, the disintegration time is controlled by the content of sodium bicarbonate present in the effervescent mixture as well as the granule size. The stability of formulations when exposed to moisture is strongly influenced by the percentage of effervescent mixture present in the vegetal granules. Precautions in handling and storage should be taken to ensure the stability of these preparations. The effervescent granules produced from Maytenus ilicifolia met the pharmacopoeial quality parameters, with appropriate mechanical and physical characteristics and proved to be a promising vehicle for plant extracts. |
| first_indexed | 2024-12-14T06:48:56Z |
| format | Article |
| id | doaj.art-93da5fc14c3e4cad9837b0f28642e767 |
| institution | Directory Open Access Journal |
| issn | 2175-9790 |
| language | English |
| last_indexed | 2024-12-14T06:48:56Z |
| publishDate | 2014-04-01 |
| publisher | Universidade de São Paulo |
| record_format | Article |
| series | Brazilian Journal of Pharmaceutical Sciences |
| spelling | doaj.art-93da5fc14c3e4cad9837b0f28642e7672022-12-21T23:12:57ZengUniversidade de São PauloBrazilian Journal of Pharmaceutical Sciences2175-97902014-04-0150224325010.1590/S1984-82502014000200002S1984-82502014000200243Development and physical evaluation of Maytenus ilicifolia effervescent granules using factorial designMarcilio Sérgio Soares da Cunha-FilhoPricila Castilho GustmannFelipe Sanches GarciaEliana Martins LimaLívia Cristina Lira de Sá-BarretoThe medicinal plant Maytenus ilicifolia is a commonly used phytomedicine for the treatment of gastritis. The high dose required and low density of these extracts make necessary a daily intake of several capsules, hindering adherence to the medication. The purpose of this work was to develop a suitable dosage form for the administration of Maytenus ilicifolia using effervescent granules. A 23 factorial design was used to study the physical characteristics of the granules (particle size distribution, repose angle, Carr index, scanning electron microscopy and disintegration time). Moisture stability was also determined. According to the experimental design, granule size is the most important factor in determining the flow characteristics of effervescent granules. In turn, the disintegration time is controlled by the content of sodium bicarbonate present in the effervescent mixture as well as the granule size. The stability of formulations when exposed to moisture is strongly influenced by the percentage of effervescent mixture present in the vegetal granules. Precautions in handling and storage should be taken to ensure the stability of these preparations. The effervescent granules produced from Maytenus ilicifolia met the pharmacopoeial quality parameters, with appropriate mechanical and physical characteristics and proved to be a promising vehicle for plant extracts.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200243&lng=en&tlng=enMaytenus ilicifolia/farmacognosiaMaytenus ilicifolia/granulados efervescentesGranulados efervescentes/características físicas/planejamento fatorialGranulados efervescentes/ higroscopicidadeExtratos vegetais/veículo de administração |
| spellingShingle | Marcilio Sérgio Soares da Cunha-Filho Pricila Castilho Gustmann Felipe Sanches Garcia Eliana Martins Lima Lívia Cristina Lira de Sá-Barreto Development and physical evaluation of Maytenus ilicifolia effervescent granules using factorial design Brazilian Journal of Pharmaceutical Sciences Maytenus ilicifolia/farmacognosia Maytenus ilicifolia/granulados efervescentes Granulados efervescentes/características físicas/planejamento fatorial Granulados efervescentes/ higroscopicidade Extratos vegetais/veículo de administração |
| title | Development and physical evaluation of Maytenus ilicifolia effervescent granules using factorial design |
| title_full | Development and physical evaluation of Maytenus ilicifolia effervescent granules using factorial design |
| title_fullStr | Development and physical evaluation of Maytenus ilicifolia effervescent granules using factorial design |
| title_full_unstemmed | Development and physical evaluation of Maytenus ilicifolia effervescent granules using factorial design |
| title_short | Development and physical evaluation of Maytenus ilicifolia effervescent granules using factorial design |
| title_sort | development and physical evaluation of maytenus ilicifolia effervescent granules using factorial design |
| topic | Maytenus ilicifolia/farmacognosia Maytenus ilicifolia/granulados efervescentes Granulados efervescentes/características físicas/planejamento fatorial Granulados efervescentes/ higroscopicidade Extratos vegetais/veículo de administração |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1984-82502014000200243&lng=en&tlng=en |
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