A Novel Zinc Chelator, 1H10, Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating Zinc Toxicity and AMPK Activation

A Novel Zinc Chelator, 1H10, Ameliorates Experimental Autoimmune Encephalomyelitis by Modulating Zinc Toxicity and AMPK Activation

Previous studies in our lab revealed that chemical zinc chelation or zinc transporter 3 (<i>ZnT3</i>) gene deletion suppresses the clinical features and neuropathological changes associated with experimental autoimmune encephalomyelitis (EAE). In addition, although protective functions a...

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Bibliographic Details
Main Authors: Bo Young Choi, Jeong Hyun Jeong, Jae-Won Eom, Jae-Young Koh, Yang-Hee Kim, Sang Won Suh
Format: Article
Language:English
Published: MDPI AG 2020-05-01
Series:International Journal of Molecular Sciences
Subjects:
experimental autoimmune encephalomyelitis
zinc
AMPK
multiple sclerosis
microglia
BBB disruption
Online Access:https://www.mdpi.com/1422-0067/21/9/3375

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