Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver Injury
Background:Reynoutria multiflora (Thunb.) Moldenke (PM) is a widely-used medicinal plant in China, whose root and stem are included in the Chinese Pharmacopoeia as Polygoni Multiflori Radix (RPM), Polygoni Multiflori Radix Preparata (PMP), and Polygoni Multiflori Caulis (PMC). The hepatotoxicity of...
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Frontiers Media S.A.
2022-04-01
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| Series: | Frontiers in Pharmacology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fphar.2022.868327/full |
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| author | Wei-Song Kong Gui Zhou Li-Wei Xu Li-Wei Xu Kun Wang Kun Wang Yi-Ming Feng Li-Yu Tao Rui-Fang Xie Ming Yang Xin Zhou |
| author_facet | Wei-Song Kong Gui Zhou Li-Wei Xu Li-Wei Xu Kun Wang Kun Wang Yi-Ming Feng Li-Yu Tao Rui-Fang Xie Ming Yang Xin Zhou |
| author_sort | Wei-Song Kong |
| collection | DOAJ |
| description | Background:Reynoutria multiflora (Thunb.) Moldenke (PM) is a widely-used medicinal plant in China, whose root and stem are included in the Chinese Pharmacopoeia as Polygoni Multiflori Radix (RPM), Polygoni Multiflori Radix Preparata (PMP), and Polygoni Multiflori Caulis (PMC). The hepatotoxicity of RPM and PMP is concerned by the public, while the risk of PMC is ignored.Purpose: Here, we investigate the potential risks for PMC-induced liver injury from clinical, chemical, and animal features.Study design: First, we analyzed the 12-month usage of RPM, PMP, and PMC in Longhua Hospital. Second, we determined the contents of gallic acid, cis-2,3,5,4′-tetrahydroxy-stilbene-2-O-β-D-glucoside (cis-SG), trans-2,3,5,4′-tetrahydroxy-stilbene-2-O-β-D-glucoside (trans-SG), emodin-8-O-β-D-glucoside (EG), physcion-8-O-β-D-glucoside (PG), emodin, and physcion in the water extracts from 15 batches of RPM, PMP, and PMC. Third, we probed the hepatotoxic effect of RPM, PMP, and PMC in mice and explored the mechanism of cis-SG and trans-SG causing the liver injury at the dosages based on our results from the first and second parts.Results: PMC had nearly five times the amount of usage in both outpatient prescriptions and inpatient orders than RPM and PMP. Overall, 68% dosage of PMC was 30 g. The contents of cis-SG, trans-SG, and emodin in PMC water extracts were significantly lower than those in RPM and PMP water extracts. PMC induced milder idiosyncratic liver injury for its lower content of cis-SG and trans-SG than its root counterparts.Conclusion: The potential risks for PMC-induced liver injury should be fully aware of. |
| first_indexed | 2024-12-13T07:01:56Z |
| format | Article |
| id | doaj.art-93db2438b19b491d988addccc17a21a7 |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-13T07:01:56Z |
| publishDate | 2022-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-93db2438b19b491d988addccc17a21a72022-12-21T23:55:55ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122022-04-011310.3389/fphar.2022.868327868327Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver InjuryWei-Song Kong0Gui Zhou1Li-Wei Xu2Li-Wei Xu3Kun Wang4Kun Wang5Yi-Ming Feng6Li-Yu Tao7Rui-Fang Xie8Ming Yang9Xin Zhou10Department of Pharmacy, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Pharmacy, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Pharmacy, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Pharmacy, Suzhou Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Suzhou, ChinaDepartment of Pharmacy, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Pharmacy, Traditional Chinese Hospital of Lu’an, Anhui University of Chinese Medicine, Lu’an, ChinaDepartment of Pharmacy, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Hepatology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Pharmacy, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Pharmacy, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaDepartment of Pharmacy, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, ChinaBackground:Reynoutria multiflora (Thunb.) Moldenke (PM) is a widely-used medicinal plant in China, whose root and stem are included in the Chinese Pharmacopoeia as Polygoni Multiflori Radix (RPM), Polygoni Multiflori Radix Preparata (PMP), and Polygoni Multiflori Caulis (PMC). The hepatotoxicity of RPM and PMP is concerned by the public, while the risk of PMC is ignored.Purpose: Here, we investigate the potential risks for PMC-induced liver injury from clinical, chemical, and animal features.Study design: First, we analyzed the 12-month usage of RPM, PMP, and PMC in Longhua Hospital. Second, we determined the contents of gallic acid, cis-2,3,5,4′-tetrahydroxy-stilbene-2-O-β-D-glucoside (cis-SG), trans-2,3,5,4′-tetrahydroxy-stilbene-2-O-β-D-glucoside (trans-SG), emodin-8-O-β-D-glucoside (EG), physcion-8-O-β-D-glucoside (PG), emodin, and physcion in the water extracts from 15 batches of RPM, PMP, and PMC. Third, we probed the hepatotoxic effect of RPM, PMP, and PMC in mice and explored the mechanism of cis-SG and trans-SG causing the liver injury at the dosages based on our results from the first and second parts.Results: PMC had nearly five times the amount of usage in both outpatient prescriptions and inpatient orders than RPM and PMP. Overall, 68% dosage of PMC was 30 g. The contents of cis-SG, trans-SG, and emodin in PMC water extracts were significantly lower than those in RPM and PMP water extracts. PMC induced milder idiosyncratic liver injury for its lower content of cis-SG and trans-SG than its root counterparts.Conclusion: The potential risks for PMC-induced liver injury should be fully aware of.https://www.frontiersin.org/articles/10.3389/fphar.2022.868327/fullPolygonum multiflorum Thunb.Polygoni Multiflori Caulisliver injuryreal worldHPLC2,3,5,4′-tetrahydroxystilbence-2-O-β-D-glucoside |
| spellingShingle | Wei-Song Kong Gui Zhou Li-Wei Xu Li-Wei Xu Kun Wang Kun Wang Yi-Ming Feng Li-Yu Tao Rui-Fang Xie Ming Yang Xin Zhou Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver Injury Frontiers in Pharmacology Polygonum multiflorum Thunb. Polygoni Multiflori Caulis liver injury real world HPLC 2,3,5,4′-tetrahydroxystilbence-2-O-β-D-glucoside |
| title | Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver Injury |
| title_full | Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver Injury |
| title_fullStr | Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver Injury |
| title_full_unstemmed | Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver Injury |
| title_short | Beware of the Potential Risks for Polygoni Multiflori Caulis-Induced Liver Injury |
| title_sort | beware of the potential risks for polygoni multiflori caulis induced liver injury |
| topic | Polygonum multiflorum Thunb. Polygoni Multiflori Caulis liver injury real world HPLC 2,3,5,4′-tetrahydroxystilbence-2-O-β-D-glucoside |
| url | https://www.frontiersin.org/articles/10.3389/fphar.2022.868327/full |
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